ALLM (BioDeep_00001028716)
Secondary id: BioDeep_00000008581
代谢物信息卡片
化学式: C19H35N3O4S (401.2348)
中文名称: 钙蛋白酶抑制剂 II
谱图信息:
最多检出来源 Mentha canadensis(plant) 55.56%
分子结构信息
SMILES: CC(C)CC(C(=O)NC(CC(C)C)C(=O)NC(CCSC)C=O)NC(=O)C
InChI: InChI=1S/C19H35N3O4S/c1-12(2)9-16(20-14(5)24)19(26)22-17(10-13(3)4)18(25)21-15(11-23)7-8-27-6/h11-13,15-17H,7-10H2,1-6H3,(H,20,24)(H,21,25)(H,22,26)/t15-,16-,17-/m0/s1
描述信息
D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors > D015853 - Cysteine Proteinase Inhibitors
同义名列表
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:7209
- KEGG: C11292
- PubChem: 121855
- ChEMBL: CHEMBL318779
- CAS: 110115-07-6
- PubChem: 13467
- NIKKAJI: J668.903E
- KNApSAcK: 7209
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Emily G Hicks, Sylvie E Kandel, Jed N Lampe. Identification of Aloe-derived natural products as prospective lead scaffolds for SARS-CoV-2 main protease (Mpro) inhibitors.
Bioorganic & medicinal chemistry letters.
2022 06; 66(?):128732. doi:
10.1016/j.bmcl.2022.128732. [PMID: 35427739] - Yanmei Hu, Chunlong Ma, Tommy Szeto, Brett Hurst, Bart Tarbet, Jun Wang. Boceprevir, Calpain Inhibitors II and XII, and GC-376 Have Broad-Spectrum Antiviral Activity against Coronaviruses.
ACS infectious diseases.
2021 03; 7(3):586-597. doi:
10.1021/acsinfecdis.0c00761. [PMID: 33645977] - Ana M Matos, Francisco R Pinto, Patrícia Barros, Margarida D Amaral, Rainer Pepperkok, Paulo Matos. Inhibition of calpain 1 restores plasma membrane stability to pharmacologically rescued Phe508del-CFTR variant.
The Journal of biological chemistry.
2019 09; 294(36):13396-13410. doi:
10.1074/jbc.ra119.008738. [PMID: 31324722] - Zhihui Cai, Yanqing Zhang, Yutian Zhang, Xiaofeng Miao, Shu Li, Hui Yang, Qinjie Ling, Peter R Hoffmann, Zhi Huang. Use of a Mouse Model and Human Umbilical Vein Endothelial Cells to Investigate the Effect of Arsenic Exposure on Vascular Endothelial Function and the Associated Role of Calpains.
Environmental health perspectives.
2019 07; 127(7):77003. doi:
10.1289/ehp4538. [PMID: 31274337] - Ariane Roseblade, Frederick Luk, Alison Ung, Mary Bebawy. Targeting microparticle biogenesis: a novel approach to the circumvention of cancer multidrug resistance.
Current cancer drug targets.
2015; 15(3):205-14. doi:
10.2174/1568009615666150225121508. [PMID: 25714701] - T Ravid, R Doolman, R Avner, D Harats, J Roitelman. The ubiquitin-proteasome pathway mediates the regulated degradation of mammalian 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
The Journal of biological chemistry.
2000 Nov; 275(46):35840-7. doi:
10.1074/jbc.m004793200. [PMID: 10964918] - G DiDiodato, F J Sharom. Interaction of combinations of drugs, chemosensitizers, and peptides with the P-glycoprotein multidrug transporter.
Biochemical pharmacology.
1997 Jun; 53(12):1789-97. doi:
10.1016/s0006-2952(97)00007-5. [PMID: 9256153]
