4-[(7-Chloroquinolin-4-yl)amino]-2-(diethylaminomethyl)phenol;hydron;dichloride;dihydrate (BioDeep_00001028666)
代谢物信息卡片
4-[(7-Chloroquinolin-4-yl)amino]-2-(diethylaminomethyl)phenol;hydron;dichloride;dihydrate
化学式: C20H28Cl3N3O3 (463.1196148)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: [H+].[H+].CCN(CC)CC1=C(C=CC(=C1)NC2=C3C=CC(=CC3=NC=C2)Cl)O.O.O.[Cl-].[Cl-]
InChI: 2*1H
描述信息
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
同义名列表
相关代谢途径
Reactome(0)
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PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Stephan Chalon, M Farouk Chughlay, Nada Abla, Andre Marie Tchouatieu, Amina Haouala, Ben Hutter, Ulrike Lorch, Fiona Macintyre. Unanticipated CNS Safety Signal in a Placebo-Controlled, Randomized Trial of Co-Administered Atovaquone-Proguanil and Amodiaquine.
Clinical pharmacology and therapeutics.
2022 04; 111(4):867-877. doi:
10.1002/cpt.2404. [PMID: 34453327] - Jingqi Qian, Mian Wang, Zhaoxiang Wang, Rui Feng, Jiaqi Zhang, Chencheng Ye, Man Zhang, Baomin Wang, Liwang Cui. Development of single- and multiplex immunoassays for rapid detection and quantitation of amodiaquine in ACT drugs and rat serum.
Analytical and bioanalytical chemistry.
2022 Feb; 414(4):1631-1640. doi:
10.1007/s00216-021-03787-6. [PMID: 34846541] - Abdullahi Tsanni. African scientists race to test COVID drugs - but face major hurdles.
Nature.
2021 11; 599(7883):25-27. doi:
10.1038/d41586-021-02995-5. [PMID: 34732862] - Karnrawee Kaewkhao, Joel Tarning, Daniel Blessborn. High-throughput quantitation method for amodiaquine and desethylamodiaquine in plasma using supported liquid extraction technology.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2021 Aug; 1179(?):122887. doi:
10.1016/j.jchromb.2021.122887. [PMID: 34364298] - Aida N Kawuma, Stephen I Walimbwa, Goonaseelan Colin Pillai, Saye Khoo, Mohammed Lamorde, Roeland E Wasmann, Paolo Denti. Dolutegravir pharmacokinetics during co-administration with either artemether/lumefantrine or artesunate/amodiaquine.
The Journal of antimicrobial chemotherapy.
2021 04; 76(5):1269-1272. doi:
10.1093/jac/dkab022. [PMID: 33550391] - Neils Ben Quashie, Nancy Odurowah Duah-Quashie. Treatment of COVID-19 with Chloroquine: Implication for Malaria Chemotherapy Using ACTs in Disease Endemic Countries.
Journal of tropical pediatrics.
2021 01; 67(1):. doi:
10.1093/tropej/fmaa089. [PMID: 33367880] - Yujeong Choi, Eun Goo Lee, Gibbeum Lee, Mi Gyeong Jeong, Hyo Kyeong Kim, Ji-Hyun Oh, Sung Won Kwon, Eun Sook Hwang. Amodiaquine promotes testosterone production and de novo synthesis of cholesterol and triglycerides in Leydig cells.
Journal of lipid research.
2021; 62(?):100152. doi:
10.1016/j.jlr.2021.100152. [PMID: 34808194] - Mathieu Gendrot, Isabelle Duflot, Manon Boxberger, Océane Delandre, Priscilla Jardot, Marion Le Bideau, Julien Andreani, Isabelle Fonta, Joel Mosnier, Clara Rolland, Sébastien Hutter, Bernard La Scola, Bruno Pradines. Antimalarial artemisinin-based combination therapies (ACT) and COVID-19 in Africa: In vitro inhibition of SARS-CoV-2 replication by mefloquine-artesunate.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.
2020 Oct; 99(?):437-440. doi:
10.1016/j.ijid.2020.08.032. [PMID: 32805422] - Jun Mo Kang, Hyun Seob Lee, Junghyun Kim, Dong Ho Yang, Hye Yun Jeong, Yu Ho Lee, Dong Jin Kim, Seon Hwa Park, MinJi Sung, Jaehee Kim, Hyun Ju An, Sang Ho Lee, So Young Lee. Beneficial Effect of Chloroquine and Amodiaquine on Type 1 Diabetic Tubulopathy by Attenuating Mitochondrial Nox4 and Endoplasmic Reticulum Stress.
Journal of Korean medical science.
2020 Sep; 35(36):e305. doi:
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Malaria journal.
2020 Jul; 19(1):238. doi:
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Viruses.
2020 06; 12(6):. doi:
10.3390/v12060642. [PMID: 32545799] - Mark Olsen, Sarah E Cook, Vanthida Huang, Niels Pedersen, Brian G Murphy. Perspectives: potential therapeutic options for SARS-CoV-2 patients based on feline infectious peritonitis strategies: central nervous system invasion and drug coverage.
International journal of antimicrobial agents.
2020 Jun; 55(6):105964. doi:
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International journal of molecular sciences.
2020 May; 21(11):. doi:
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Antimicrobial agents and chemotherapy.
2020 02; 64(3):. doi:
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European journal of drug metabolism and pharmacokinetics.
2020 Feb; 45(1):81-88. doi:
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Scientific reports.
2019 12; 9(1):20199. doi:
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Experimental parasitology.
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BMC infectious diseases.
2019 May; 19(1):376. doi:
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Materials science & engineering. C, Materials for biological applications.
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Phytomedicine : international journal of phytotherapy and phytopharmacology.
2019 Apr; 57(?):49-56. doi:
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Antimicrobial agents and chemotherapy.
2019 02; 63(2):. doi:
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Journal of clinical pharmacy and therapeutics.
2018 Oct; 43(5):626-632. doi:
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Antimicrobial agents and chemotherapy.
2018 10; 62(10):. doi:
10.1128/aac.02193-17. [PMID: 30038039] - Nguyen Ngoc Quang, Marina Chavchich, Chu Xuan Anh, Geoffrey W Birrell, Karin van Breda, Thomas Travers, Kerryn Rowcliffe, Michael D Edstein. Comparison of the Pharmacokinetics and Ex Vivo Antimalarial Activities of Artesunate-Amodiaquine and Artemisinin-Piperaquine in Healthy Volunteers for Preselection Malaria Therapy.
The American journal of tropical medicine and hygiene.
2018 07; 99(1):65-72. doi:
10.4269/ajtmh.17-0434. [PMID: 29741150] - Hoe-Yune Jung, Bobae Kim, Hye Guk Ryu, Yosep Ji, Soyoung Park, Seung Hee Choi, Dohyun Lee, In-Kyu Lee, Munki Kim, You Jeong Lee, Woojin Song, Young Hee Lee, Hyung Jin Choi, Chang-Kee Hyun, Wilhelm H Holzapfel, Kyong-Tai Kim. Amodiaquine improves insulin resistance and lipid metabolism in diabetic model mice.
Diabetes, obesity & metabolism.
2018 07; 20(7):1688-1701. doi:
10.1111/dom.13284. [PMID: 29516607] - Hye Yun Jeong, Jun Mo Kang, Hak Hoon Jun, Dong-Jin Kim, Seon Hwa Park, Min Ji Sung, Jin Hyung Heo, Dong Ho Yang, Sang Ho Lee, So-Young Lee. Chloroquine and amodiaquine enhance AMPK phosphorylation and improve mitochondrial fragmentation in diabetic tubulopathy.
Scientific reports.
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The Lancet. Infectious diseases.
2018 06; 18(6):627-639. doi:
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Scientific reports.
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Archives of pharmacal research.
2017 Nov; 40(11):1336-1343. doi:
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Chemico-biological interactions.
2017 Jun; 271(?):24-29. doi:
10.1016/j.cbi.2017.04.025. [PMID: 28457856] - Awodayo O Adepiti, Ezekiel O Iwalewa. Evaluation of the combination of Uvaria chamae (P. Beauv.) and amodiaquine in murine malaria.
Journal of ethnopharmacology.
2016 Dec; 193(?):30-35. doi:
10.1016/j.jep.2016.07.035. [PMID: 27416806] - Awodayo O Adepiti, Anthony A Elujoba, Oluseye O Bolaji. Evaluation of herbal antimalarial MAMA decoction-amodiaquine combination in murine malaria model.
Pharmaceutical biology.
2016 Oct; 54(10):2298-303. doi:
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Journal of immunotoxicology.
2016 09; 13(5):694-712. doi:
10.3109/1547691x.2016.1166167. [PMID: 27416278] - Dhiraj M Rathod, Keyur R Patel, Hiren N Mistri, Arvind G Jangid, Pranav S Shrivastav, Mallika Sanyal. Application of an LC-MS/MS method for reliable determination of amodiaquine, N-desethylamodiaquine, artesunate and dihydroartemisinin in human plasma for a bioequivalence study in healthy Indian subjects.
Journal of pharmaceutical and biomedical analysis.
2016 May; 124(?):67-78. doi:
10.1016/j.jpba.2016.02.021. [PMID: 26930583] - Lawrence G Febir, Kwaku Poku Asante, Samuel Afari-Asiedu, Livesy N Abokyi, Anthony Kwarteng, Bernhards Ogutu, Margaret Gyapong, Seth Owusu-Agyei. Seeking treatment for uncomplicated malaria: experiences from the Kintampo districts of Ghana.
Malaria journal.
2016 Feb; 15(?):108. doi:
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Molecular reproduction and development.
2016 Feb; 83(2):174-82. doi:
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PloS one.
2016; 11(8):e0160091. doi:
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Malaria journal.
2015 Sep; 14(?):347. doi:
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Antimicrobial agents and chemotherapy.
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Xenobiotica; the fate of foreign compounds in biological systems.
2015 May; 45(5):406-12. doi:
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Antimicrobial agents and chemotherapy.
2014 Oct; 58(10):6009-15. doi:
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Antimicrobial agents and chemotherapy.
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Antimicrobial agents and chemotherapy.
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2011 Jul; 55(7):3363-9. doi:
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Transactions of the Royal Society of Tropical Medicine and Hygiene.
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Antimicrobial agents and chemotherapy.
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Transactions of the Royal Society of Tropical Medicine and Hygiene.
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2009 Dec; 24(2):101-6. doi:
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European journal of drug metabolism and pharmacokinetics.
2009 Jul; 34(3-4):133-42. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
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Antimicrobial agents and chemotherapy.
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Pakistan journal of biological sciences : PJBS.
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Transactions of the Royal Society of Tropical Medicine and Hygiene.
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European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology.
2008 Jul; 27(7):627-9. doi:
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European journal of pharmacology.
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