Pravachol (BioDeep_00001028619)
代谢物信息卡片
Pravachol
化学式: C23H35O7- (423.238266)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCC(C)C(=O)OC1CC(C=C2C1C(C(C=C2)C)CCC(CC(CC(=O)[O-])O)O)O
InChI: InChI=1S/C23H36O7/c1-4-13(2)23(29)30-20-11-17(25)9-15-6-5-14(3)19(22(15)20)8-7-16(24)10-18(26)12-21(27)28/h5-6,9,13-14,16-20,22,24-26H,4,7-8,10-12H2,1-3H3,(H,27,28)/p-1/t13-,14-,16+,17+,18+,19-,20-,22-/m0/s1
描述信息
D057847 - Lipid Regulating Agents > D000960 - Hypolipidemic Agents > D000924 - Anticholesteremic Agents
D004791 - Enzyme Inhibitors > D019161 - Hydroxymethylglutaryl-CoA Reductase Inhibitors
D009676 - Noxae > D000963 - Antimetabolites
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Tingting Fu, Valentina Calabrese, Sarah Bancel, Hervé Quéau, Laura Garnero, Nicolas Delorme, Khedidja Abbaci, Arnaud Salvador, Arnaud Chaumot, Olivier Geffard, Davide Degli-Esposti, Sophie Ayciriex. ToF-SIMS imaging shows specific lipophilic vitamin alterations in chronic reprotoxicity caused by the emerging contaminant Pravastatin in Gammarus fossarum.
Aquatic toxicology (Amsterdam, Netherlands).
2024 Jun; 271(?):106935. doi:
10.1016/j.aquatox.2024.106935. [PMID: 38723468] - Hacer Kayhan Kaya, Berjan Demirtas, Beran Yokus, Dilek Aygün Kesim, Ezel Tasdemir, Abdurrahman Sermet. Comparative effects of pravastatin and rosuvastatin on carbohydrate metabolism in an experimental diabetic rat model.
Acta pharmaceutica (Zagreb, Croatia).
2024 Mar; 74(1):117-130. doi:
10.2478/acph-2024-0001. [PMID: 38554383] - Paolo Raggi, Farzin M Takyar, Varuna Gadiyaram, Chao Zhang, Arthur E Stillman, Amir H Davarpanah. Differential effect of atorvastatin and pravastatin on thoracic spine attenuation: A sub-analysis of a randomized clinical trial.
Atherosclerosis.
2024 Jan; 388(?):117425. doi:
10.1016/j.atherosclerosis.2023.117425. [PMID: 38109819] - Cong Chen, Zheng-Feng Liang, Yu-Qi He, An-Qi Li, Yan Gao, Qun-Wen Pan, Jing-Song Cao. Pravastatin promotes type 2 diabetes vascular calcification through activating intestinal Bacteroides fragilis to induce macrophage M1 polarization.
Journal of diabetes.
2023 Dec; ?(?):. doi:
10.1111/1753-0407.13514. [PMID: 38112268] - Abhinav Rana, Thakur Uttam Singh, Meemansha Sharma, Manju Gari, Tarun Kumar, Subhashree Parida, Madhu Cholenahalli Lingaraju, Asok Kumar Mariappan, Akhilesh Kumar, Dinesh Kumar. Pravastatin attenuates isoprenaline induced cardiac fibrosis in a mouse model.
Biotechnic & histochemistry : official publication of the Biological Stain Commission.
2023 Oct; ?(?):1-11. doi:
10.1080/10520295.2023.2260303. [PMID: 37814775] - Stephen P Adams, Nima Alaeiilkhchi, Sara Tasnim, James M Wright. Pravastatin for lowering lipids.
The Cochrane database of systematic reviews.
2023 09; 9(?):CD013673. doi:
10.1002/14651858.cd013673.pub2. [PMID: 37721222] - Caroline Nb Clezar, Carolina Dq Flumignan, Nicolle Cassola, Luis Cu Nakano, Virginia Fm Trevisani, Ronald Lg Flumignan. Pharmacological interventions for asymptomatic carotid stenosis.
The Cochrane database of systematic reviews.
2023 Aug; 8(?):CD013573. doi:
10.1002/14651858.cd013573.pub2. [PMID: 37565307] - Jin Xu, Liyuan Zhu, Yingying Xie, Miao Zhang, Zixi Xiao, Rongkai Su, Tie Wen, Ling Liu. Effects of xuezhikang versus pravastatin on triglyceride level in patients with T2DM and dyslipidemia: study protocol for a multicenter randomized controlled trial.
Current vascular pharmacology.
2023 Mar; ?(?):. doi:
10.2174/1570161121666230328110215. [PMID: 36998136] - Ruifeng Liang, Wenjing Ge, Bingjie Li, Weifeng Cui, Xiaofan Ma, Yuying Pan, Gengsheng Li. Evodiamine decreased the systemic exposure of pravastatin in non-alcoholic steatohepatitis rats due to the up-regulation of hepatic OATPs.
Pharmaceutical biology.
2022 Dec; 60(1):359-373. doi:
10.1080/13880209.2022.2036767. [PMID: 35171063] - Hulusi Bulent Zeyneloglu, Yusuf Aytac Tohma, Emre Gunakan, Mehmet Ali Abasıyanık, Ceren Sozen, Gogsen Onalan. Diet and pravastatin administration prior to in vitro fertilization treatment may improve pregnancy outcome in women with dyslipidemia.
Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology.
2022 Aug; 42(6):2235-2240. doi:
10.1080/01443615.2022.2036968. [PMID: 35257641] - Ferran Trias, Xavier Pintó, Emili Corbella, Manuel Suárez-Tembra, Antonio Ruíz-García, José Luis Díaz-Díaz, Elena Sánchez-Ruíz-Granado, Itziar Sarasa, Raul Martínez-Porqueras, Maria Angeles Rodríguez-Sánchez, Xavier Corbella. Differences in the diabetogenic effect of statins in patients with prediabetes. The PRELIPID study.
Medicina clinica.
2022 06; 158(11):531-539. doi:
10.1016/j.medcli.2021.06.018. [PMID: 34517987] - Jumpei Saito, Kayoko Kaneko, Sawako Abe, Naho Yakuwa, Hiroyo Kawasaki, Tomo Suzuki, Akimasa Yamatani, Haruhiko Sago, Atsuko Murashima. Pravastatin concentrations in maternal serum, umbilical cord serum, breast milk and neonatal serum during pregnancy and lactation: A case study.
Journal of clinical pharmacy and therapeutics.
2022 May; 47(5):703-706. doi:
10.1111/jcpt.13590. [PMID: 34951046] - Zhen Zhou, Andrea J Curtis, Michael E Ernst, Joanne Ryan, Sophia Zoungas, Rory Wolfe, John J McNeil, Anne M Murray, Christopher M Reid, Enayet K Chowdhury, Robyn L Woods, Andrew M Tonkin, Mark R Nelson. Comparison of statins for primary prevention of cardiovascular disease and persistent physical disability in older adults.
European journal of clinical pharmacology.
2022 Mar; 78(3):467-476. doi:
10.1007/s00228-021-03239-1. [PMID: 34698889] - Kacey Anderson, Cara H Nelson, Qi Gong, Muhsen Alani, Thomas Tarnowski, Ahmed A Othman. Assessment of the Effect of Filgotinib on the Pharmacokinetics of Atorvastatin, Pravastatin, and Rosuvastatin in Healthy Adult Participants.
Clinical pharmacology in drug development.
2022 02; 11(2):235-245. doi:
10.1002/cpdd.1015. [PMID: 34468080] - Stephen Tong, Tu'uhevaha J Kaitu'u-Lino, Roxanne Hastie, Fiona Brownfoot, Catherine Cluver, Natalie Hannan. Pravastatin, proton-pump inhibitors, metformin, micronutrients, and biologics: new horizons for the prevention or treatment of preeclampsia.
American journal of obstetrics and gynecology.
2022 02; 226(2S):S1157-S1170. doi:
10.1016/j.ajog.2020.09.014. [PMID: 32946849] - Seo Young Kang, Tae Hee Jeon, Keun-Sang Yum, Sung Sunwoo, Hyun-Young Shin, Dae Hyun Kim, Kiduk Kim, Jong Lull Yoon, Jae-Kyung Choi, Young Sik Kim. Relationship between Dietary Habits and Control of Lipid Profiles in Patients with Dyslipidemia Using Pravastatin.
Nutrients.
2021 Oct; 13(11):. doi:
10.3390/nu13113784. [PMID: 34836040] - Fuyo Takeda, Masako Oda, Masaru Terasaki, Atsuhito Kubota, Keita Asada, Yuichi Ichimura, Hiroyuki Kojima, Hiroshi Saitoh. Downregulated expression of organic anion transporting polypeptide (Oatp) 2b1 in the small intestine of rats with acute kidney injury.
Drug metabolism and pharmacokinetics.
2021 Oct; 40(?):100411. doi:
10.1016/j.dmpk.2021.100411. [PMID: 34284282] - Yong Wang, Xiaoguang Lu, Xiaoping Wang, Qi Qiu, Ping Zhu, Lin Ma, Xiao Ma, Joerg Herrmann, Xueying Lin, Wei Wang, Xiaolei Xu. atg7-Based Autophagy Activation Reverses Doxorubicin-Induced Cardiotoxicity.
Circulation research.
2021 10; 129(8):e166-e182. doi:
10.1161/circresaha.121.319104. [PMID: 34384247] - Moritz Döbert, Anna Nektaria Varouxaki, An Chi Mu, Argyro Syngelaki, Anca Ciobanu, Ranjit Akolekar, Catalina De Paco Matallana, Simona Cicero, Elena Greco, Mandeep Singh, Deepa Janga, Maria Del Mar Gil, Jacques C Jani, José Luis Bartha, Kate Maclagan, David Wright, Kypros H Nicolaides. Pravastatin Versus Placebo in Pregnancies at High Risk of Term Preeclampsia.
Circulation.
2021 08; 144(9):670-679. doi:
10.1161/circulationaha.121.053963. [PMID: 34162218] - Christine M Bowman, Buyun Chen, Jonathan Cheong, Liling Liu, Yuan Chen, Jialin Mao. Improving the Translation of Organic Anion Transporting Polypeptide Substrates using HEK293 Cell Data in the Presence and Absence of Human Plasma via Physiologically Based Pharmacokinetic Modeling.
Drug metabolism and disposition: the biological fate of chemicals.
2021 07; 49(7):530-539. doi:
10.1124/dmd.120.000315. [PMID: 33958385] - V Sashi Gopaul, Elsbet J Pieterman, Hans M G Princen, Linnéa Bergenholm, Eva Lundborg, Anders Cavallin, Magnus J Johansson, Glen Hawthorne, Anders Björkbom, Maria Hammarberg, XueQing Li, Annica Jarke, Jonathan Bright, Lena Svensson, Rasmus Jansson-Löfmark, Bertil Abrahamsson, Rahul Agrawal, Eva Hurt-Camejo. Effects of mineral oil administration on the pharmacokinetics, metabolism and pharmacodynamics of atorvastatin and pravastatin in mice and dogs.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2021 Jun; 161(?):105776. doi:
10.1016/j.ejps.2021.105776. [PMID: 33667667] - Hatice Nurdan Aksoy, Cagatay Ceylan. Comparison of the Effects of Statins on A549 Nonsmall-Cell Lung Cancer Cell Line Lipids Using Fourier Transform Infrared Spectroscopy: Rosuvastatin Stands Out.
Lipids.
2021 05; 56(3):289-299. doi:
10.1002/lipd.12296. [PMID: 33611813] - Staci L Haney, Michelle L Varney, Yashpal Chhonker, Geoffrey Talmon, Lynette M Smith, Daryl J Murry, Sarah A Holstein. In vivo evaluation of combination therapy targeting the isoprenoid biosynthetic pathway.
Pharmacological research.
2021 05; 167(?):105528. doi:
10.1016/j.phrs.2021.105528. [PMID: 33667685] - Madhurima M Baliga, Jost Klawitter, Uwe Christians, Katharina Hopp, Michel Chonchol, Berenice Y Gitomer, Melissa A Cadnapaphornchai, Jelena Klawitter. Metabolic profiling in children and young adults with autosomal dominant polycystic kidney disease.
Scientific reports.
2021 03; 11(1):6629. doi:
10.1038/s41598-021-84609-8. [PMID: 33758231] - Bo Feng, Rachel Pemberton, Wojciech Dworakowski, Zhengqi Ye, Craig Zetterberg, Guanyu Wang, Yoshio Morikawa, Sanjeev Kumar. Evaluation of the Utility of PXB Chimeric Mice for Predicting Human Liver Partitioning of Hepatic Organic Anion-Transporting Polypeptide Transporter Substrates.
Drug metabolism and disposition: the biological fate of chemicals.
2021 03; 49(3):254-264. doi:
10.1124/dmd.120.000276. [PMID: 33376106] - Anita Virtanen, Outi Huttala, Kati Tihtonen, Tarja Toimela, Tuula Heinonen, Hannele Laivuori, Jukka Uotila. Angiogenic Effect of Pravastatin Alone and with Sera from Healthy and Complicated Pregnancies Studied by in vitro Vasculogenesis/Angiogenesis Assay.
Journal of vascular research.
2021; 58(3):139-147. doi:
10.1159/000512831. [PMID: 33571991] - Fan Deng, Jing-Juan Hu, Xiao Yang, Qi-Shun Sun, Ze-Bin Lin, Bing-Cheng Zhao, Zhi-Wen Yao, Si-Dan Luo, Ze-Ling Chen, Ying Liu, Zheng-Zheng Yan, Cai Li, Wei-Feng Liu, Ke-Xuan Liu. Gut Microbial Metabolite Pravastatin Attenuates Intestinal Ischemia/Reperfusion Injury Through Promoting IL-13 Release From Type II Innate Lymphoid Cells via IL-33/ST2 Signaling.
Frontiers in immunology.
2021; 12(?):704836. doi:
10.3389/fimmu.2021.704836. [PMID: 34650552] - Eleftheria Lefkou, Katerina Varoudi, Joaquim Pombo, Aleksandar Jurisic, Zaklina Jurisic, Greg Contento, Guillermina Girardi. Triple therapy with pravastatin, low molecular weight heparin and low dose aspirin improves placental haemodynamics and pregnancy outcomes in obstetric antiphospholipid syndrome in mice and women through a nitric oxide-dependent mechanism.
Biochemical pharmacology.
2020 12; 182(?):114217. doi:
10.1016/j.bcp.2020.114217. [PMID: 32926874] - G-J Wang, Z Yang, J Huai, Q-Q Xiang. Pravastatin alleviates oxidative stress and decreases placental trophoblastic cell apoptosis through IL-6/STAT3 signaling pathway in preeclampsia rats.
European review for medical and pharmacological sciences.
2020 12; 24(24):12955-12962. doi:
10.26355/eurrev_202012_24199. [PMID: 33378046] - Jonathan B Wagner, Melissa Ruggiero, J Steven Leeder, Bruno Hagenbuch. Functional Consequences of Pravastatin Isomerization on OATP1B1-Mediated Transport.
Drug metabolism and disposition: the biological fate of chemicals.
2020 11; 48(11):1192-1198. doi:
10.1124/dmd.120.000122. [PMID: 32892153] - Begoña Lavin Plaza, Alkystis Phinikaridou, Marcelo E Andia, Myles Potter, Silvia Lorrio, Imran Rashid, Rene M Botnar. Sustained Focal Vascular Inflammation Accelerates Atherosclerosis in Remote Arteries.
Arteriosclerosis, thrombosis, and vascular biology.
2020 09; 40(9):2159-2170. doi:
10.1161/atvbaha.120.314387. [PMID: 32673527] - Keigo Nakayama, Hidetaka Kamimura, Hiroshi Suemizu, Nao Yoneda, Megumi Nishiwaki, Kazuhiko Iwamoto, Mari Mizunaga, Tamotsu Negoro, Soichiro Ito, Hiroshi Yamazaki, Yukihiro Nomura. Predicted values for human total clearance of a variety of typical compounds with differently humanized-liver mouse plasma data.
Drug metabolism and pharmacokinetics.
2020 Aug; 35(4):389-396. doi:
10.1016/j.dmpk.2020.05.004. [PMID: 32690433] - Sotirios Tsimikas, Philip L S M Gordts, Chelsea Nora, Calvin Yeang, Joseph L Witztum. Statin therapy increases lipoprotein(a) levels.
European heart journal.
2020 06; 41(24):2275-2284. doi:
10.1093/eurheartj/ehz310. [PMID: 31111151] - David C Boettiger, Anthony T Newall, Pairoj Chattranukulchai, Romanee Chaiwarith, Suwimon Khusuwan, Anchalee Avihingsanon, Andrew Phillips, Eran Bendavid, Matthew G Law, James G Kahn, Jeremy Ross, Sergio Bautista-Arredondo, Sasisopin Kiertiburanakul. Statins for atherosclerotic cardiovascular disease prevention in people living with HIV in Thailand: a cost-effectiveness analysis.
Journal of the International AIDS Society.
2020 06; 23 Suppl 1(?):e25494. doi:
10.1002/jia2.25494. [PMID: 32562359] - Lea Wagmann, Selina Hemmer, Achim T Caspar, Markus R Meyer. Method development for quantitative determination of seven statins including four active metabolites by means of high-resolution tandem mass spectrometry applicable for adherence testing and therapeutic drug monitoring.
Clinical chemistry and laboratory medicine.
2020 04; 58(5):664-672. doi:
10.1515/cclm-2019-0763. [PMID: 31665111] - Erica L Toth, John D Clarke, Iván L Csanaky, Nathan J Cherrington. Interaction of Oatp1b2 expression and nonalcoholic steatohepatitis on pravastatin plasma clearance.
Biochemical pharmacology.
2020 04; 174(?):113780. doi:
10.1016/j.bcp.2019.113780. [PMID: 31881192] - Karoline Mayer-Pickel, Christina Stern, Mila Cervar-Zivkovic, Wolfgang Schöll, Manfred Moertl. Preeclampsia before fetal viability in women with primary antiphospholipid syndrome- materno-fetal outcomes in a series of 7 cases.
Journal of reproductive immunology.
2020 04; 138(?):103101. doi:
10.1016/j.jri.2020.103101. [PMID: 32114217] - A Ahmed, D J Williams, V Cheed, L J Middleton, S Ahmad, K Wang, A T Vince, P Hewett, K Spencer, K S Khan, J P Daniels. Pravastatin for early-onset pre-eclampsia: a randomised, blinded, placebo-controlled trial.
BJOG : an international journal of obstetrics and gynaecology.
2020 03; 127(4):478-488. doi:
10.1111/1471-0528.16013. [PMID: 31715077] - Heera Ram, Noopur Jaipal, Jaykaran Charan, Priya Kashyap, Suresh Kumar, Rashmi Tripathi, Bhim Pratap Singh, Chandra Nayaka Siddaiah, Abeer Hashem, Baby Tabassum, Elsayed Fathi Abd Allah. Phytoconstituents of an ethanolic pod extract of Prosopis cineraria triggers the inhibition of HMG-CoA reductase and the regression of atherosclerotic plaque in hypercholesterolemic rabbits.
Lipids in health and disease.
2020 Jan; 19(1):6. doi:
10.1186/s12944-020-1188-z. [PMID: 31931807] - Christine M Bowman, Eugene Chen, Liuxi Chen, Yi-Chen Chen, Xiaorong Liang, Matthew Wright, Yuan Chen, Jialin Mao. Changes in Organic Anion Transporting Polypeptide Uptake in HEK293 Overexpressing Cells in the Presence and Absence of Human Plasma.
Drug metabolism and disposition: the biological fate of chemicals.
2020 01; 48(1):18-24. doi:
10.1124/dmd.119.088948. [PMID: 31699807] - K Esmeijer, Olaf M Dekkers, Johan W de Fijter, Friedo W Dekker, Ellen K Hoogeveen. Effect of different types of statins on kidney function decline and proteinuria: a network meta-analysis.
Scientific reports.
2019 11; 9(1):16632. doi:
10.1038/s41598-019-53064-x. [PMID: 31719617] - Hwa Young Lee, Eung Gu Lee, Jung Hur, Chin Kook Rhee, Young Kyoon Kim, Sook Young Lee, Ji Young Kang. Pravastatin alleviates allergic airway inflammation in obesity-related asthma mouse model.
Experimental lung research.
2019 Nov; 45(9-10):275-287. doi:
10.1080/01902148.2019.1675807. [PMID: 31608695] - Ji Woong Roh, Kyeong-Hyeon Chun, Moonjong Kang, Chan Joo Lee, Jaewon Oh, Chi-Young Shim, Chul-Min Ahn, Jung-Sun Kim, Byeong-Keuk Kim, Sungha Park, Hyuk-Jae Chang, Geu-Ru Hong, Young-Guk Ko, Seok-Min Kang, Donghoon Choi, Jong-Won Ha, Myeong-Ki Hong, Yangsoo Jang, Sang-Hak Lee. PRavastatin Versus FlUVastatin After Statin Intolerance: The PRUV-Intolerance Study With Propensity Score Matching.
The American journal of medicine.
2019 11; 132(11):1320-1326.e1. doi:
10.1016/j.amjmed.2019.06.003. [PMID: 31278931] - Oludamilola W Oluleye, Richard A Kronmal, Aaron R Folsom, Dhananjay M Vaidya, Pamela Ouyang, Daniel A Duprez, Adrian S Dobs, Hirad Yarmohammadi, Suma H Konety. Association Between Statin Use and Sex Hormone in the Multi-Ethnic Study of Atherosclerosis Cohort.
The Journal of clinical endocrinology and metabolism.
2019 10; 104(10):4600-4606. doi:
10.1210/jc.2019-00530. [PMID: 31157875] - Q Q Xiang, Z Yang, J Huai, G J Wang. [Different effects of pravastatin on sFlt-1, PlGF and VEGF in different preeclampsia-like mouse models].
Zhonghua fu chan ke za zhi.
2019 Sep; 54(9):601-607. doi:
10.3760/cma.j.issn.0529-567x.2019.09.005. [PMID: 31550776] - Kerry S Flannagan, Lindsey A Sjaarda, Micah J Hill, Matthew T Connell, Jessica R Zolton, Neil J Perkins, Sunni L Mumford, Torie C Plowden, Victoria C Andriessen, Jeannie G Radoc, Enrique F Schisterman. Pilot randomized trial of short-term changes in inflammation and lipid levels during and after aspirin and pravastatin therapy.
Reproductive health.
2019 Sep; 16(1):132. doi:
10.1186/s12978-019-0794-6. [PMID: 31477152] - Perrine Courlet, Dany Spaggiari, Vincent Desfontaine, Matthias Cavassini, Susana Alves Saldanha, Thierry Buclin, Catia Marzolini, Chantal Csajka, Laurent-Arthur Decosterd. UHPLC-MS/MS assay for simultaneous determination of amlodipine, metoprolol, pravastatin, rosuvastatin, atorvastatin with its active metabolites in human plasma, for population-scale drug-drug interactions studies in people living with HIV.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2019 09; 1125(?):121733. doi:
10.1016/j.jchromb.2019.121733. [PMID: 31374423] - C M Gordon, R H Cleveland, K Baltrusaitis, J Massaro, R B D'Agostino, M G Liang, B Snyder, M Walters, X Li, D T Braddock, M E Kleinman, M W Kieran, L B Gordon. Extraskeletal Calcifications in Hutchinson-Gilford Progeria Syndrome.
Bone.
2019 08; 125(?):103-111. doi:
10.1016/j.bone.2019.05.008. [PMID: 31077852] - Kaushala S Jayawardana, Piyushkumar A Mundra, Corey Giles, Christopher K Barlow, Paul J Nestel, Elizabeth H Barnes, Adrienne Kirby, Peter Thompson, David R Sullivan, Zahir H Alshehry, Natalie A Mellett, Kevin Huynh, Malcolm J McConville, Sophia Zoungas, Graham S Hillis, John Chalmers, Mark Woodward, Ian C Marschner, Gerard Wong, Bronwyn A Kingwell, John Simes, Andrew M Tonkin, Peter J Meikle. Changes in plasma lipids predict pravastatin efficacy in secondary prevention.
JCI insight.
2019 07; 4(13):. doi:
10.1172/jci.insight.128438. [PMID: 31292301] - Sook Wah Yee, Marilyn M Giacomini, Hong Shen, W Griffith Humphreys, Howard Horng, William Brian, Yurong Lai, Deanna L Kroetz, Kathleen M Giacomini. Organic Anion Transporter Polypeptide 1B1 Polymorphism Modulates the Extent of Drug-Drug Interaction and Associated Biomarker Levels in Healthy Volunteers.
Clinical and translational science.
2019 07; 12(4):388-399. doi:
10.1111/cts.12625. [PMID: 30982223] - Paolo Raggi, Varuna Gadiyaram, Chao Zhang, Zhengjia Chen, Gary Lopaschuk, Arthur E Stillman. Statins Reduce Epicardial Adipose Tissue Attenuation Independent of Lipid Lowering: A Potential Pleiotropic Effect.
Journal of the American Heart Association.
2019 06; 8(12):e013104. doi:
10.1161/jaha.119.013104. [PMID: 31190609] - Qinghui Xiong, Zhijun Wang, Ying Yu, Yadan Wen, Rinkiko Suguro, Yicheng Mao, Yi Zhun Zhu. Hydrogen sulfide stabilizes atherosclerotic plaques in apolipoprotein E knockout mice.
Pharmacological research.
2019 06; 144(?):90-98. doi:
10.1016/j.phrs.2019.04.006. [PMID: 30959158] - Eisei Hori, Chigusa Kikuchi, Kenro Imaeda, Naotsuka Okayama, Tadashi Suzuki, Tamihide Matsunaga. [Effect of Statins on Glycemic Status and Plasma Adiponectin Concentrations in Patients with Type 2 Diabetes Mellitus and Hypercholesterolemia].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.
2019 May; 139(5):807-815. doi:
10.1248/yakushi.18-00218. [PMID: 30773524] - Rafael Carmena, D John Betteridge. Diabetogenic Action of Statins: Mechanisms.
Current atherosclerosis reports.
2019 04; 21(6):23. doi:
10.1007/s11883-019-0780-z. [PMID: 31037345] - Christine M Bowman, Hideaki Okochi, Leslie Z Benet. The Presence of a Transporter-Induced Protein Binding Shift: A New Explanation for Protein-Facilitated Uptake and Improvement for In Vitro-In Vivo Extrapolation.
Drug metabolism and disposition: the biological fate of chemicals.
2019 04; 47(4):358-363. doi:
10.1124/dmd.118.085779. [PMID: 30674616] - Henock G Yebyo, Hélène E Aschmann, Marco Kaufmann, Milo A Puhan. Comparative effectiveness and safety of statins as a class and of specific statins for primary prevention of cardiovascular disease: A systematic review, meta-analysis, and network meta-analysis of randomized trials with 94,283 participants.
American heart journal.
2019 04; 210(?):18-28. doi:
10.1016/j.ahj.2018.12.007. [PMID: 30716508] - Hitoshi Uchiyama, Masayuki Tsujimoto, Akari Kimura, Eriko Yuki, Takashi Saiki, Takuya Yoshida, Taku Furukubo, Satoshi Izumi, Tomoyuki Yamakawa, Hidehisa Tachiki, Tetsuya Minegaki, Kohshi Nishiguchi. Effects of Uremic Serum Residue on OATP1B1- and OATP1B3-Mediated Pravastatin Uptake in OATP-Expressing HEK293 Cells and Human Hepatocytes.
Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy.
2019 Apr; 23(2):126-132. doi:
10.1111/1744-9987.12758. [PMID: 30318712] - Hae-Ri Lee, Min-Kyung Jo, Kyung-Yeon Park, You-Jin Jang, Tae-Hwe Heo. Anti-TNF effect of combined pravastatin and cilostazol treatment in an in vivo mouse model.
Immunopharmacology and immunotoxicology.
2019 Apr; 41(2):179-184. doi:
10.1080/08923973.2019.1569045. [PMID: 30714456] - Yong Pyo Lee, Yuri Cho, Eun Jee Kim, Hyojung Lee, Hoon Young Choi, Hye Jin Wang, Eun Seok Kang, Yu Seun Kim, Myoung Soo Kim, Beom Seok Kim. Reduced expression of pyruvate kinase in kidney proximal tubule cells is a potential mechanism of pravastatin altered glucose metabolism.
Scientific reports.
2019 03; 9(1):5318. doi:
10.1038/s41598-019-39461-2. [PMID: 30926836] - Jing Huai, Zi Yang, Yan-Hong Yi, Guang-Jiao Wang. Role of mammalian target of rapamycin signaling pathway in regulation of fatty acid oxidation in a preeclampsia-like mouse model treated with pravastatin.
Chinese medical journal.
2019 Mar; 132(6):671-679. doi:
10.1097/cm9.0000000000000129. [PMID: 30855348] - Mohammed M Mehanna, Mohamad Ibrahim Shabarek, Hoda A Elmaradny, Hoda A Elmartadny. Spray-dried pH-sensitive microparticles: effectual methodology to ameliorate the bioavailability of acid labile pravastatin.
Drug development and industrial pharmacy.
2019 03; 45(3):485-497. doi:
10.1080/03639045.2018.1562465. [PMID: 30575415] - Leisan F Galiullina, Holger A Scheidt, Daniel Huster, Albert Aganov, Vladimir Klochkov. Interaction of statins with phospholipid bilayers studied by solid-state NMR spectroscopy.
Biochimica et biophysica acta. Biomembranes.
2019 03; 1861(3):584-593. doi:
10.1016/j.bbamem.2018.12.013. [PMID: 30578770] - Anna Sokalska, Amanda B Hawkins, Toshia Yamaguchi, Antoni J Duleba. Lipophilic statins inhibit growth and reduce invasiveness of human endometrial stromal cells.
Journal of assisted reproduction and genetics.
2019 Mar; 36(3):535-541. doi:
10.1007/s10815-018-1352-9. [PMID: 30554393] - S D'Addato, F Fogacci, A F G Cicero, S Palmisano, F Baronio, C Biagi, C Borghi. Severe hypercholesterolaemia in a paediatric patient with congenital analbuminaemia.
Nutrition, metabolism, and cardiovascular diseases : NMCD.
2019 03; 29(3):316-317. doi:
10.1016/j.numecd.2018.11.005. [PMID: 30639253] - Okki Cho, Han-Sol Kim, Kyung-Yeon Park, Tae-Hwe Heo. A Comparison of the Anti-Inflammatory Effects of Four Combined Statin and Antiplatelet Therapies on Tumor Necrosis Factor-Mediated Acute Inflammation in vivo.
Pharmacology.
2019; 104(1-2):21-27. doi:
10.1159/000499335. [PMID: 30970359] - Roberval N M Neto, Edelvio de Barros Gomes, Lucas Weba-Soares, Léo R L Dias, Luís C N da Silva, Rita de C M de Miranda. Biotechnological Production of Statins: Metabolic Aspects and Genetic Approaches.
Current pharmaceutical biotechnology.
2019; 20(15):1244-1259. doi:
10.2174/1389201020666190718165746. [PMID: 31333127] - Yan Chen, Li-Bin Li, Jun Zhang, Du-Peng Tang, Jing-Jing Wei, Ze-Hao Zhuang. Simvastatin, but not pravastatin, inhibits the proliferation of esophageal adenocarcinoma and squamous cell carcinoma cells: a cell-molecular study.
Lipids in health and disease.
2018 Dec; 17(1):290. doi:
10.1186/s12944-018-0946-7. [PMID: 30579354] - Arrigo F G Cicero, Federica Fogacci, Marilisa Bove, Fulvio Ventura, Marina Giovannini, Claudio Borghi. Optimizing Lipid Pattern by Adding a Combined Nutraceutical or Pravastatin to Fenofibrate Treatment in Hypertriglyceridemic Subjects: Single Site, Randomized, Open-Label, Post-Market Clinical Investigation.
High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension.
2018 Dec; 25(4):355-359. doi:
10.1007/s40292-018-0277-9. [PMID: 30229462] - Kyung-Yeon Park, Tae-Hwe Heo. Combination therapy with cilostazol and pravastatin improves antiatherogenic effects in low-density lipoprotein receptor knockout mice.
Cardiovascular therapeutics.
2018 Dec; 36(6):e12476. doi:
10.1111/1755-5922.12476. [PMID: 30378752] - Eeva Sliz, Johannes Kettunen, Michael V Holmes, Clare Oliver Williams, Charles Boachie, Qin Wang, Minna Männikkö, Sylvain Sebert, Robin Walters, Kuang Lin, Iona Y Millwood, Robert Clarke, Liming Li, Naomi Rankin, Paul Welsh, Christian Delles, J Wouter Jukema, Stella Trompet, Ian Ford, Markus Perola, Veikko Salomaa, Marjo-Riitta Järvelin, Zhengming Chen, Debbie A Lawlor, Mika Ala-Korpela, John Danesh, George Davey Smith, Naveed Sattar, Adam Butterworth, Peter Würtz. Metabolomic consequences of genetic inhibition of PCSK9 compared with statin treatment.
Circulation.
2018 11; 138(22):2499-2512. doi:
". [PMID: 30524137] - Ariela R Orkaby, Michael W Rich, Ryan Sun, Eliah Lux, Lee-Jen Wei, Dae Hyun Kim. Pravastatin for Primary Prevention in Older Adults: Restricted Mean Survival Time Analysis.
Journal of the American Geriatrics Society.
2018 10; 66(10):1987-1991. doi:
10.1111/jgs.15509. [PMID: 30251369] - John Simes, Kristy P Robledo, Harvey D White, David Espinoza, Ralph A Stewart, David R Sullivan, Tanja Zeller, Wendy Hague, Paul J Nestel, Paul P Glasziou, Anthony C Keech, John Elliott, Stefan Blankenberg, Andrew M Tonkin. D-Dimer Predicts Long-Term Cause-Specific Mortality, Cardiovascular Events, and Cancer in Patients With Stable Coronary Heart Disease: LIPID Study.
Circulation.
2018 08; 138(7):712-723. doi:
10.1161/circulationaha.117.029901. [PMID: 29367425] - Xiaoling Zhang, Shengjun Xiao, Quanzhong Li. Pravastatin polarizes the phenotype of macrophages toward M2 and elevates serum cholesterol levels in apolipoprotein E knockout mice.
The Journal of international medical research.
2018 Aug; 46(8):3365-3373. doi:
10.1177/0300060518787671. [PMID: 30058421] - H-M Wang, J-H Gao, J-L Lu. Pravastatin improves atherosclerosis in mice with hyperlipidemia by inhibiting TREM-1/DAP12.
European review for medical and pharmacological sciences.
2018 08; 22(15):4995-5003. doi:
10.26355/eurrev_201808_15640. [PMID: 30070336] - Meifeng Liu, Guiting Liu, Meiying Wang. Comparison and analysis of the therapeutic effect of different statins in the treatment of atherosclerosis.
Pakistan journal of pharmaceutical sciences.
2018 Jul; 31(4(Special)):1737-1742. doi:
". [PMID: 30203772] - Massa Oi, Daniel Donner, Jason Peart, Belinda Beck, Lauren Wendt, John P Headrick, Eugene F du Toit. Pravastatin improves risk factors but not ischaemic tolerance in obese rats.
European journal of pharmacology.
2018 May; 826(?):148-157. doi:
10.1016/j.ejphar.2018.02.050. [PMID: 29501869] - Xingchi Chen, Sainan Wang, Lulu Lin, Yu Li, Hui Zhang. Drug effect of atorvastatin on middle cerebral atherosclerotic stenosis and high resolution NMR diagnosis.
Pakistan journal of pharmaceutical sciences.
2018 May; 31(3(Special)):1169-1173. doi:
". [PMID: 29735469] - Ken-Ichi Kaneko, Masaaki Tanaka, Akira Ishii, Yumiko Katayama, Takayoshi Nakaoka, Satsuki Irie, Hideki Kawahata, Takashi Yamanaga, Yasuhiro Wada, Takeshi Miyake, Kota Toshimoto, Kazuya Maeda, Yilong Cui, Masaru Enomoto, Etsushi Kawamura, Norifumi Kawada, Joji Kawabe, Susumu Shiomi, Hiroyuki Kusuhara, Yuichi Sugiyama, Yasuyoshi Watanabe. A Clinical Quantitative Evaluation of Hepatobiliary Transport of [11C]Dehydropravastatin in Humans Using Positron Emission Tomography.
Drug metabolism and disposition: the biological fate of chemicals.
2018 05; 46(5):719-728. doi:
10.1124/dmd.118.080408. [PMID: 29555827] - Jialin Mao, Utkarsh Doshi, Matthew Wright, Cornelis E C A Hop, Albert P Li, Yuan Chen. Prediction of the Pharmacokinetics of Pravastatin as an OATP Substrate Using Plateable Human Hepatocytes With Human Plasma Data and PBPK Modeling.
CPT: pharmacometrics & systems pharmacology.
2018 04; 7(4):251-258. doi:
10.1002/psp4.12283. [PMID: 29388346] - Jing Huai, Zi Yang, Yan-Hong Yi, Guang-Jiao Wang. Different Effects of Pravastatin on Preeclampsia-like Symptoms in Different Mouse Models.
Chinese medical journal.
2018 Feb; 131(4):461-470. doi:
10.4103/0366-6999.225058. [PMID: 29451152] - Abdel K Raffoul-Orozco, Ana E Ávila-González, Christian M Rodríguez-Razón, Teresa A García-Cobian, Edsaul E Pérez-Guerrero, Trinidad García-Iglesias, Edy David Rubio-Arellano. Combination effect naringin and pravastatin in lipid profile and glucose in obese rats.
Life sciences.
2018 Jan; 193(?):87-92. doi:
10.1016/j.lfs.2017.11.044. [PMID: 29197498] - Dylan L Steen, Amarachi A Umez-Eronini, Jianping Guo, Naseer Khan, Christopher P Cannon. The effect of fasting status on lipids, lipoproteins, and inflammatory biomarkers assessed after hospitalization for an acute coronary syndrome: Insights from PROVE IT-TIMI 22.
Clinical cardiology.
2018 Jan; 41(1):68-73. doi:
10.1002/clc.22851. [PMID: 29283450] - Kyung-Yeon Park, Tae-Hwe Heo. Critical role of TNF inhibition in combination therapy for elderly mice with atherosclerosis.
Cardiovascular therapeutics.
2017 Dec; 35(6):. doi:
10.1111/1755-5922.12280. [PMID: 28643478] - Ralph A H Stewart, David M Colquhoun, Simone L Marschner, Adrienne C Kirby, John Simes, Paul J Nestel, Nick Glozier, Adrienne O'Neil, Brian Oldenburg, Harvey D White, Andrew M Tonkin. Persistent psychological distress and mortality in patients with stable coronary artery disease.
Heart (British Cardiac Society).
2017 12; 103(23):1860-1866. doi:
10.1136/heartjnl-2016-311097. [PMID: 28652315] - Daniel Kofink, Ruben N Eppinga, Wiek H van Gilst, Stephan J L Bakker, Robin P F Dullaart, Pim van der Harst, Folkert W Asselbergs. Statin Effects on Metabolic Profiles: Data From the PREVEND IT (Prevention of Renal and Vascular End-stage Disease Intervention Trial).
Circulation. Cardiovascular genetics.
2017 Dec; 10(6):. doi:
10.1161/circgenetics.117.001759. [PMID: 29237679] - Antonio J Vallejo-Vaz, Michele Robertson, Alberico L Catapano, Gerald F Watts, John J Kastelein, Chris J Packard, Ian Ford, Kausik K Ray. Low-Density Lipoprotein Cholesterol Lowering for the Primary Prevention of Cardiovascular Disease Among Men With Primary Elevations of Low-Density Lipoprotein Cholesterol Levels of 190 mg/dL or Above: Analyses From the WOSCOPS (West of Scotland Coronary Prevention Study) 5-Year Randomized Trial and 20-Year Observational Follow-Up.
Circulation.
2017 Nov; 136(20):1878-1891. doi:
10.1161/circulationaha.117.027966. [PMID: 28877913] - Eisei Hori, Chigusa Kikuchi, Chie Nagami, Junko Kajikuri, Takeo Itoh, Masayoshi Takeuchi, Tamihide Matsunaga. Role of Glyceraldehyde-Derived AGEs and Mitochondria in Superoxide Production in Femoral Artery of OLETF Rat and Effects of Pravastatin.
Biological & pharmaceutical bulletin.
2017 Nov; 40(11):1903-1908. doi:
10.1248/bpb.b17-00411. [PMID: 28835584] - Quantil M Melendez, Catherine J Wooten, Dayami Lopez. Atorvastatin and lovastatin, but not pravastatin, increased cellular complex formation between PCSK9 and the LDL receptor in human hepatocyte-like C3A cells.
Biochemical and biophysical research communications.
2017 10; 492(1):103-108. doi:
10.1016/j.bbrc.2017.08.026. [PMID: 28802576] - Francesca Urbano, Marco Bugliani, Agnese Filippello, Alessandra Scamporrino, Stefania Di Mauro, Antonino Di Pino, Roberto Scicali, Davide Noto, Agata Maria Rabuazzo, Maurizio Averna, Piero Marchetti, Francesco Purrello, Salvatore Piro. Atorvastatin but Not Pravastatin Impairs Mitochondrial Function in Human Pancreatic Islets and Rat β-Cells. Direct Effect of Oxidative Stress.
Scientific reports.
2017 09; 7(1):11863. doi:
10.1038/s41598-017-11070-x. [PMID: 28928397] - Kayoko Kanamitsu, Hiroyuki Kusuhara, John D Schuetz, Kenji Takeuchi, Yuichi Sugiyama. Investigation of the Importance of Multidrug Resistance-Associated Protein 4 (Mrp4/Abcc4) in the Active Efflux of Anionic Drugs Across the Blood-Brain Barrier.
Journal of pharmaceutical sciences.
2017 09; 106(9):2566-2575. doi:
10.1016/j.xphs.2017.04.040. [PMID: 28456721] - James A Carroll, Brent Race, Katie Phillips, James F Striebel, Bruce Chesebro. Statins are ineffective at reducing neuroinflammation or prolonging survival in scrapie-infected mice.
The Journal of general virology.
2017 Aug; 98(8):2190-2199. doi:
10.1099/jgv.0.000876. [PMID: 28758631] - Mary E Walker, Patricia R Souza, Romain A Colas, Jesmond Dalli. 13-Series resolvins mediate the leukocyte-platelet actions of atorvastatin and pravastatin in inflammatory arthritis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2017 08; 31(8):3636-3648. doi:
10.1096/fj.201700268. [PMID: 28465323] - Judith A Aberg, Craig A Sponseller, Douglas J Ward, Vladimir A Kryzhanovski, Stuart E Campbell, Melanie A Thompson. Pitavastatin versus pravastatin in adults with HIV-1 infection and dyslipidaemia (INTREPID): 12 week and 52 week results of a phase 4, multicentre, randomised, double-blind, superiority trial.
The lancet. HIV.
2017 07; 4(7):e284-e294. doi:
10.1016/s2352-3018(17)30075-9. [PMID: 28416195] - Benjamin H Han, David Sutin, Jeff D Williamson, Barry R Davis, Linda B Piller, Hannah Pervin, Sara L Pressel, Caroline S Blaum. Effect of Statin Treatment vs Usual Care on Primary Cardiovascular Prevention Among Older Adults: The ALLHAT-LLT Randomized Clinical Trial.
JAMA internal medicine.
2017 07; 177(7):955-965. doi:
10.1001/jamainternmed.2017.1442. [PMID: 28531241] - Toshiaki Otsuka, Kyoichi Mizuno, Tomohiro Shinozaki, Yuko Kachi, Haruo Nakamura. Preventive effect of pravastatin on the development of hypertension in patients with hypercholesterolemia: A post-hoc analysis of the Management of Elevated Cholesterol in the Primary Prevention Group of Adult Japanese (MEGA) Study.
Journal of clinical lipidology.
2017 Jul; 11(4):998-1006. doi:
10.1016/j.jacl.2017.05.015. [PMID: 28655522] - Magnus Asping, Nis Stride, Ditte Søgaard, Tine Lovsø Dohlmann, Jørn W Helge, Flemming Dela, Steen Larsen. The effects of 2 weeks of statin treatment on mitochondrial respiratory capacity in middle-aged males: the LIFESTAT study.
European journal of clinical pharmacology.
2017 Jun; 73(6):679-687. doi:
10.1007/s00228-017-2224-4. [PMID: 28246888] - Normand Podechard, Martine Chevanne, Morgane Fernier, Arnaud Tête, Aurore Collin, Doris Cassio, Olivier Kah, Dominique Lagadic-Gossmann, Odile Sergent. Zebrafish larva as a reliable model for in vivo assessment of membrane remodeling involvement in the hepatotoxicity of chemical agents.
Journal of applied toxicology : JAT.
2017 06; 37(6):732-746. doi:
10.1002/jat.3421. [PMID: 27896850] - Brian Z Huang, Jonathan I Chang, Erica Li, Anny H Xiang, Bechien U Wu. Influence of Statins and Cholesterol on Mortality Among Patients With Pancreatic Cancer.
Journal of the National Cancer Institute.
2017 05; 109(5):. doi:
10.1093/jnci/djw275. [PMID: 28040693] - Jie-Hua Shi, Qi Wang, Dong-Qi Pan, Ting-Ting Liu, Min Jiang. Characterization of interactions of simvastatin, pravastatin, fluvastatin, and pitavastatin with bovine serum albumin: multiple spectroscopic and molecular docking.
Journal of biomolecular structure & dynamics.
2017 May; 35(7):1529-1546. doi:
10.1080/07391102.2016.1188416. [PMID: 27484332]