3beta-(2-Diethylaminoethoxy)androst-5-en-17-one hydrochloride (BioDeep_00001028538)
代谢物信息卡片
3beta-(2-Diethylaminoethoxy)androst-5-en-17-one hydrochloride
化学式: C25H42ClNO2 (423.29039020000005)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCN(CC)CCOC1CCC2(C3CCC4(C(C3CC=C2C1)CCC4=O)C)C.Cl
InChI: /m0./s1
描述信息
D057847 - Lipid Regulating Agents > D000960 - Hypolipidemic Agents > D000924 - Anticholesteremic Agents
D009676 - Noxae > D000963 - Antimetabolites
D004791 - Enzyme Inhibitors
同义名列表
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Saman Yasamineh, Fatemeh Jabbari Mehrabani, Ehsan Derafsh, Renizo Danihiel Cosimi, Amir Mohammad Karimi Forood, Siamak Soltani, Meead Hadi, Omid Gholizadeh. Potential Use of the Cholesterol Transfer Inhibitor U18666A as a Potent Research Tool for the Study of Cholesterol Mechanisms in Neurodegenerative Disorders.
Molecular neurobiology.
2024 Jun; 61(6):3503-3527. doi:
10.1007/s12035-023-03798-7. [PMID: 37995080] - Marjan Assefi, Reza Bijan Rostami, Menooa Ebrahimi, Mana Altafi, Pooya M Tehrany, Haider Kamil Zaidan, Bashar Zuhair Talib Al-Naqeeb, Meead Hadi, Saman Yasamineh, Omid Gholizadeh. Potential use of the cholesterol transfer inhibitor U18666A as an antiviral drug for research on various viral infections.
Microbial pathogenesis.
2023 Jun; 179(?):106096. doi:
10.1016/j.micpath.2023.106096. [PMID: 37011734] - Guoli Li, Bingqian Su, Pengfei Fu, Yilin Bai, Guangxu Ding, Dahua Li, Jiang Wang, Guoyu Yang, Beibei Chu. NPC1-regulated dynamic of clathrin-coated pits is essential for viral entry.
Science China. Life sciences.
2022 02; 65(2):341-361. doi:
10.1007/s11427-021-1929-y. [PMID: 34047913] - Xu Xiao, Youngjae Kim, Beatriz Romartinez-Alonso, Kristupas Sirvydis, Daniel S Ory, John W R Schwabe, Michael E Jung, Peter Tontonoz. Selective Aster inhibitors distinguish vesicular and nonvesicular sterol transport mechanisms.
Proceedings of the National Academy of Sciences of the United States of America.
2021 01; 118(2):. doi:
10.1073/pnas.2024149118. [PMID: 33376205] - Jue Zhang, Xin Li, Hui Yu, Isabel Larre, Prabhatchandra R Dube, David J Kennedy, W H Wilson Tang, Kristen Westfall, Sandrine V Pierre, Zijian Xie, Yiliang Chen. Regulation of Na/K-ATPase expression by cholesterol: isoform specificity and the molecular mechanism.
American journal of physiology. Cell physiology.
2020 12; 319(6):C1107-C1119. doi:
10.1152/ajpcell.00083.2020. [PMID: 32997514] - Stephen L Sturley, Tamayanthi Rajakumar, Natalie Hammond, Katsumi Higaki, Zsuzsa Márka, Szabolcs Márka, Andrew B Munkacsi. Potential COVID-19 therapeutics from a rare disease: weaponizing lipid dysregulation to combat viral infectivity.
Journal of lipid research.
2020 07; 61(7):972-982. doi:
10.1194/jlr.r120000851. [PMID: 32457038] - Simon Wheeler, Per Haberkant, Meenakshi Bhardwaj, Paige Tongue, Maria J Ferraz, David Halter, Hein Sprong, Ralf Schmid, Johannes M F G Aerts, Nikol Sullo, Dan J Sillence. Cytosolic glucosylceramide regulates endolysosomal function in Niemann-Pick type C disease.
Neurobiology of disease.
2019 07; 127(?):242-252. doi:
10.1016/j.nbd.2019.03.005. [PMID: 30872158] - Christoph Müller, Sandra Hemmers, Nicholas Bartl, Alois Plodek, Andreas Körner, Valbona Mirakaj, Martin Giera, Franz Bracher. New chemotype of selective and potent inhibitors of human delta 24-dehydrocholesterol reductase.
European journal of medicinal chemistry.
2017 Nov; 140(?):305-320. doi:
10.1016/j.ejmech.2017.08.011. [PMID: 28964935] - Michael N Trinh, Feiran Lu, Xiaochun Li, Akash Das, Qiren Liang, Jef K De Brabander, Michael S Brown, Joseph L Goldstein. Triazoles inhibit cholesterol export from lysosomes by binding to NPC1.
Proceedings of the National Academy of Sciences of the United States of America.
2017 01; 114(1):89-94. doi:
10.1073/pnas.1619571114. [PMID: 27994139] - Yun-Ui Bae, Jae-Wan Huh, Bieong-Kil Kim, Hyeon Young Park, Young-Bae Seu, Kyung-Oh Doh. Enhancement of liposome mediated gene transfer by adding cholesterol and cholesterol modulating drugs.
Biochimica et biophysica acta.
2016 12; 1858(12):3017-3023. doi:
10.1016/j.bbamem.2016.09.013. [PMID: 27664498] - Duyen Quach, Cecilia Vitali, Fiona M La, Angel X Xiao, John S Millar, Chongren Tang, Daniel J Rader, Michael C Phillips, Nicholas N Lyssenko. Cell lipid metabolism modulators 2-bromopalmitate, D609, monensin, U18666A and probucol shift discoidal HDL formation to the smaller-sized particles: implications for the mechanism of HDL assembly.
Biochimica et biophysica acta.
2016 12; 1861(12 Pt A):1968-1979. doi:
10.1016/j.bbalip.2016.09.017. [PMID: 27671775] - Macarena Hernández-Jiménez, Diego Martínez-López, Enrique Gabandé-Rodríguez, Adrian Martín-Segura, Ignacio Lizasoain, María D Ledesma, Carlos G Dotti, María A Moro. Seladin-1/DHCR24 Is Neuroprotective by Associating EAAT2 Glutamate Transporter to Lipid Rafts in Experimental Stroke.
Stroke.
2016 Jan; 47(1):206-13. doi:
10.1161/strokeaha.115.010810. [PMID: 26628388] - Daniela Copetti-Santos, Vitoria Moraes, Dácio Franco Weiler, Alexandre Silva de Mello, Fernanda de Souza Machado, Jéssica Pereira Marinho, Cassiana Siebert, Janaina Kolling, Cláudia Funchal, Angela T S Wyse, Janice Carneiro Coelho. U18666A Treatment Results in Cholesterol Accumulation, Reduced Na(+), K(+)-ATPase Activity, and Increased Oxidative Stress in Rat Cortical Astrocytes.
Lipids.
2015 Oct; 50(10):937-44. doi:
10.1007/s11745-015-4062-4. [PMID: 26344921] - Ahmed A Eltoukhy, Gaurav Sahay, James M Cunningham, Daniel G Anderson. Niemann-Pick C1 affects the gene delivery efficacy of degradable polymeric nanoparticles.
ACS nano.
2014 Aug; 8(8):7905-13. doi:
10.1021/nn501630h. [PMID: 25010491] - Sabine Chapuy-Regaud, Caroline Subra, Mary Requena, Philippe de Medina, Sawsan Amara, Isabelle Delton-Vandenbroucke, Bruno Payre, Michelle Cazabat, Frédéric Carriere, Jacques Izopet, Marc Poirot, Michel Record. Progesterone and a phospholipase inhibitor increase the endosomal bis(monoacylglycero)phosphate content and block HIV viral particle intercellular transmission.
Biochimie.
2013 Sep; 95(9):1677-88. doi:
10.1016/j.biochi.2013.05.019. [PMID: 23774297] - Vilja Pietiäinen, Boris Vassilev, Tomas Blom, Wei Wang, Jessica Nelson, Robert Bittman, Nils Bäck, Noam Zelcer, Elina Ikonen. NDRG1 functions in LDL receptor trafficking by regulating endosomal recycling and degradation.
Journal of cell science.
2013 Sep; 126(Pt 17):3961-71. doi:
10.1242/jcs.128132. [PMID: 23813961] - Zeina Chamoun, Fabrizio Vacca, Robert G Parton, Jean Gruenberg. PNPLA3/adiponutrin functions in lipid droplet formation.
Biology of the cell.
2013 May; 105(5):219-233. doi:
10.1111/boc.201200036. [PMID: 23398201] - Mary Carmen Vázquez, Pablo Martínez, Alejandra R Alvarez, Mauricio González, Silvana Zanlungo. Increased copper levels in in vitro and in vivo models of Niemann-Pick C disease.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine.
2012 Aug; 25(4):777-86. doi:
10.1007/s10534-012-9546-6. [PMID: 22526561] - Hiroyuki Nakamura, Kana Yasufuku, Tomohiko Makiyama, Ikiru Matsumoto, Hiromichi Fujino, Toshihiko Murayama. Arachidonic acid metabolism via cytosolic phospholipase A2 α induces cytotoxicity in niemann-pick disease type C cells.
Journal of cellular physiology.
2012 Jul; 227(7):2847-55. doi:
10.1002/jcp.23025. [PMID: 21928312] - Blair R Roszell, Jian-Qin Tao, Kevin J Yu, Shaohui Huang, Sandra R Bates. Characterization of the Niemann-Pick C pathway in alveolar type II cells and lamellar bodies of the lung.
American journal of physiology. Lung cellular and molecular physiology.
2012 May; 302(9):L919-32. doi:
10.1152/ajplung.00383.2011. [PMID: 22367786] - Dorothy I Mundy, Wei Ping Li, Katherine Luby-Phelps, Richard G W Anderson. Caveolin targeting to late endosome/lysosomal membranes is induced by perturbations of lysosomal pH and cholesterol content.
Molecular biology of the cell.
2012 Mar; 23(5):864-80. doi:
10.1091/mbc.e11-07-0598. [PMID: 22238363] - Yvonne Lange, Jin Ye, Theodore L Steck. Activation mobilizes the cholesterol in the late endosomes-lysosomes of Niemann Pick type C cells.
PloS one.
2012; 7(1):e30051. doi:
10.1371/journal.pone.0030051. [PMID: 22276143] - Hanna Appelqvist, Linnea Sandin, Karin Björnström, Paul Saftig, Brett Garner, Karin Ollinger, Katarina Kågedal. Sensitivity to lysosome-dependent cell death is directly regulated by lysosomal cholesterol content.
PloS one.
2012; 7(11):e50262. doi:
10.1371/journal.pone.0050262. [PMID: 23166840] - Elena Piccoli, Matteo Nadai, Carla Mucignat Caretta, Valeria Bergonzini, Claudia Del Vecchio, Huy Riem Ha, Laurent Bigler, Daniele Dal Zoppo, Elisabetta Faggin, Andrea Pettenazzo, Rocco Orlando, Cristiano Salata, Arianna Calistri, Giorgio Palù, Aldo Baritussio. Amiodarone impairs trafficking through late endosomes inducing a Niemann-Pick C-like phenotype.
Biochemical pharmacology.
2011 Nov; 82(9):1234-49. doi:
10.1016/j.bcp.2011.07.090. [PMID: 21878321] - Takashi Takano, Kyoko Tsukiyama-Kohara, Masahiro Hayashi, Yuichi Hirata, Masaaki Satoh, Yuko Tokunaga, Chise Tateno, Yukiko Hayashi, Tsunekazu Hishima, Nobuaki Funata, Masayuki Sudoh, Michinori Kohara. Augmentation of DHCR24 expression by hepatitis C virus infection facilitates viral replication in hepatocytes.
Journal of hepatology.
2011 Sep; 55(3):512-521. doi:
10.1016/j.jhep.2010.12.011. [PMID: 21184787] - Hao-Ping Liu, Chih-Ching Wu, Hung-Yi Kao, Yi-Chuan Huang, Ying Liang, Chia-Chun Chen, Jau-Song Yu, Yu-Sun Chang. Proteome-wide dysregulation by PRA1 depletion delineates a role of PRA1 in lipid transport and cell migration.
Molecular & cellular proteomics : MCP.
2011 Mar; 10(3):M900641MCP200. doi:
10.1074/mcp.m900641-mcp200. [PMID: 20592422] - Thomas Pfeifer, Marlene Buchebner, Prakash G Chandak, Jay Patankar, Adelheid Kratzer, Sascha Obrowsky, Gerald N Rechberger, Rajendra S Kadam, Uday B Kompella, Gerhard M Kostner, Dagmar Kratky, Sanja Levak-Frank. Synthetic LXR agonist suppresses endogenous cholesterol biosynthesis and efficiently lowers plasma cholesterol.
Current pharmaceutical biotechnology.
2011 Feb; 12(2):285-92. doi:
10.2174/138920111794295774. [PMID: 21190543] - Hanna Appelqvist, Cathrine Nilsson, Brett Garner, Andrew J Brown, Katarina Kågedal, Karin Ollinger. Attenuation of the lysosomal death pathway by lysosomal cholesterol accumulation.
The American journal of pathology.
2011 Feb; 178(2):629-39. doi:
10.1016/j.ajpath.2010.10.030. [PMID: 21281795] - Anton I Rosenbaum, Guangtao Zhang, J David Warren, Frederick R Maxfield. Endocytosis of beta-cyclodextrins is responsible for cholesterol reduction in Niemann-Pick type C mutant cells.
Proceedings of the National Academy of Sciences of the United States of America.
2010 Mar; 107(12):5477-82. doi:
10.1073/pnas.0914309107. [PMID: 20212119] - Sabine Gilch, Christian Bach, Gloria Lutzny, Ina Vorberg, Hermann M Schätzl. Inhibition of cholesterol recycling impairs cellular PrP(Sc) propagation.
Cellular and molecular life sciences : CMLS.
2009 Dec; 66(24):3979-91. doi:
10.1007/s00018-009-0158-4. [PMID: 19823766] - Yvonne Lange, Theodore L Steck, Jin Ye, Michael H Lanier, Vasumathi Molugu, Daniel Ory. Regulation of fibroblast mitochondrial 27-hydroxycholesterol production by active plasma membrane cholesterol.
Journal of lipid research.
2009 Sep; 50(9):1881-8. doi:
10.1194/jlr.m900116-jlr200. [PMID: 19401598] - Richard J Cenedella. Cholesterol synthesis inhibitor U18666A and the role of sterol metabolism and trafficking in numerous pathophysiological processes.
Lipids.
2009 Jun; 44(6):477-87. doi:
10.1007/s11745-009-3305-7. [PMID: 19440746] - Chikatoshi Yanagimoto, Masaru Harada, Hiroto Kumemura, Hironori Koga, Takumi Kawaguchi, Kunihiko Terada, Shinichiro Hanada, Eitaro Taniguchi, Yukio Koizumi, Souichi Koyota, Haruaki Ninomiya, Takato Ueno, Toshihiro Sugiyama, Michio Sata. Niemann-Pick C1 protein transports copper to the secretory compartment from late endosomes where ATP7B resides.
Experimental cell research.
2009 Jan; 315(2):119-26. doi:
10.1016/j.yexcr.2008.10.022. [PMID: 19007772] - Jill Kuglin Schweitzer, Sean D Pietrini, Crislyn D'Souza-Schorey. ARF6-mediated endosome recycling reverses lipid accumulation defects in Niemann-Pick Type C disease.
PloS one.
2009; 4(4):e5193. doi:
10.1371/journal.pone.0005193. [PMID: 19365558] - Kassidy K Huynh, Elena Gershenzon, Sergio Grinstein. Cholesterol accumulation by macrophages impairs phagosome maturation.
The Journal of biological chemistry.
2008 Dec; 283(51):35745-55. doi:
10.1074/jbc.m806232200. [PMID: 18955491] - Céline Lafourcade, Komla Sobo, Sylvie Kieffer-Jaquinod, Jérome Garin, F Gisou van der Goot. Regulation of the V-ATPase along the endocytic pathway occurs through reversible subunit association and membrane localization.
PloS one.
2008 Jul; 3(7):e2758. doi:
10.1371/journal.pone.0002758. [PMID: 18648502] - Giacomo Diaz, Barbara Batetta, Francesca Sanna, Sabrina Uda, Camilla Reali, Fabrizio Angius, Marta Melis, Angela Maria Falchi. Lipid droplet changes in proliferating and quiescent 3T3 fibroblasts.
Histochemistry and cell biology.
2008 May; 129(5):611-21. doi:
10.1007/s00418-008-0402-2. [PMID: 18297300] - S Lucken-Ardjomande, S Montessuit, J-C Martinou. Bax activation and stress-induced apoptosis delayed by the accumulation of cholesterol in mitochondrial membranes.
Cell death and differentiation.
2008 Mar; 15(3):484-93. doi:
10.1038/sj.cdd.4402280. [PMID: 18084240] - Tamara A Pagler, Angelika Neuhofer, Hildegard Laggner, Wolfgang Strobl, Herbert Stangl. Cholesterol efflux via HDL resecretion occurs when cholesterol transport out of the lysosome is impaired.
Journal of lipid research.
2007 Oct; 48(10):2141-50. doi:
10.1194/jlr.m700056-jlr200. [PMID: 17620658] - Chor Hui Vivien Koh, Zhao Feng Peng, Keli Ou, Alirio Melendez, Jayapal Manikandan, Robert Z Qi, Nam Sang Cheung. Neuronal apoptosis mediated by inhibition of intracellular cholesterol transport: microarray and proteomics analyses in cultured murine cortical neurons.
Journal of cellular physiology.
2007 Apr; 211(1):63-87. doi:
10.1002/jcp.20912. [PMID: 17245753] - Arnold H Van der Luit, Marianne Budde, Shuraila Zerp, Wendy Caan, Jeffrey B Klarenbeek, Marcel Verheij, Wim J Van Blitterswijk. Resistance to alkyl-lysophospholipid-induced apoptosis due to downregulated sphingomyelin synthase 1 expression with consequent sphingomyelin- and cholesterol-deficiency in lipid rafts.
The Biochemical journal.
2007 Jan; 401(2):541-9. doi:
10.1042/bj20061178. [PMID: 17049047] - Ralf Klingenstein, Stefan Löber, Pekka Kujala, Susan Godsave, S Rutger Leliveld, Peter Gmeiner, Peter J Peters, Carsten Korth. Tricyclic antidepressants, quinacrine and a novel, synthetic chimera thereof clear prions by destabilizing detergent-resistant membrane compartments.
Journal of neurochemistry.
2006 Aug; 98(3):748-59. doi:
10.1111/j.1471-4159.2006.03889.x. [PMID: 16749906] - Chor Hui Vivien Koh, Matthew Whiteman, Qiao-Xin Li, Barry Halliwell, Andrew M Jenner, Boon Seng Wong, Katrina M Laughton, Markus Wenk, Colin L Masters, Philip M Beart, Ora Bernard, Nam Sang Cheung. Chronic exposure to U18666A is associated with oxidative stress in cultured murine cortical neurons.
Journal of neurochemistry.
2006 Aug; 98(4):1278-89. doi:
10.1111/j.1471-4159.2006.03958.x. [PMID: 16771828] - Dale Howe, Robert A Heinzen. Coxiella burnetii inhabits a cholesterol-rich vacuole and influences cellular cholesterol metabolism.
Cellular microbiology.
2006 Mar; 8(3):496-507. doi:
10.1111/j.1462-5822.2005.00641.x. [PMID: 16469060] - Haibo Zhao, H Kalervo Väänänen. Pharmacological sequestration of intracellular cholesterol in late endosomes disrupts ruffled border formation in osteoclasts.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
2006 Mar; 21(3):456-65. doi:
10.1359/jbmr.051204. [PMID: 16491294] - Nina H Pipalia, Amy Huang, Harold Ralph, Madalina Rujoi, Frederick R Maxfield. Automated microscopy screening for compounds that partially revert cholesterol accumulation in Niemann-Pick C cells.
Journal of lipid research.
2006 Feb; 47(2):284-301. doi:
10.1194/jlr.m500388-jlr200. [PMID: 16288097] - Patrick Lajoie, Ginette Guay, James W Dennis, Ivan R Nabi. The lipid composition of autophagic vacuoles regulates expression of multilamellar bodies.
Journal of cell science.
2005 May; 118(Pt 9):1991-2003. doi:
10.1242/jcs.02324. [PMID: 15840653] - Warren Davis, Jonathan T Boyd, Kristina E Ile, Kenneth D Tew. Human ATP-binding cassette transporter-2 (ABCA2) positively regulates low-density lipoprotein receptor expression and negatively regulates cholesterol esterification in Chinese hamster ovary cells.
Biochimica et biophysica acta.
2004 Jul; 1683(1-3):89-100. doi:
10.1016/j.bbalip.2004.04.009. [PMID: 15238223] - Richard J Cenedella, Robert Jacob, Douglas Borchman, Daxin Tang, Amanda R Neely, Abbas Samadi, R Preston Mason, Patricia Sexton. Direct perturbation of lens membrane structure may contribute to cataracts caused by U18666A, an oxidosqualene cyclase inhibitor.
Journal of lipid research.
2004 Jul; 45(7):1232-41. doi:
10.1194/jlr.m300469-jlr200. [PMID: 15102886] - Marc Issandou, Raphaëlle Guillard, Anne-Benedicte Boullay, Valerie Linhart, Elvira Lopez-Perez. Up-regulation of low-density lipoprotein receptor in human hepatocytes is induced by sequestration of free cholesterol in the endosomal/lysosomal compartment.
Biochemical pharmacology.
2004 Jun; 67(12):2281-9. doi:
10.1016/j.bcp.2004.03.006. [PMID: 15163559] - Edward B Neufeld, John A Stonik, Stephen J Demosky, Catherine L Knapper, Christian A Combs, Adele Cooney, Marcella Comly, Nancy Dwyer, Joan Blanchette-Mackie, Alan T Remaley, Silvia Santamarina-Fojo, H Bryan Brewer. The ABCA1 transporter modulates late endocytic trafficking: insights from the correction of the genetic defect in Tangier disease.
The Journal of biological chemistry.
2004 Apr; 279(15):15571-8. doi:
10.1074/jbc.m314160200. [PMID: 14747463] - Lee-Way Jin, Feng-Shium Shie, Izumi Maezawa, Inez Vincent, Thomas Bird. Intracellular accumulation of amyloidogenic fragments of amyloid-beta precursor protein in neurons with Niemann-Pick type C defects is associated with endosomal abnormalities.
The American journal of pathology.
2004 Mar; 164(3):975-85. doi:
10.1016/s0002-9440(10)63185-9. [PMID: 14982851] - Andrew R Leventhal, Christina C Leslie, Ira Tabas. Suppression of macrophage eicosanoid synthesis by atherogenic lipoproteins is profoundly affected by cholesterol-fatty acyl esterification and the Niemann-Pick C pathway of lipid trafficking.
The Journal of biological chemistry.
2004 Feb; 279(9):8084-92. doi:
10.1074/jbc.m310672200. [PMID: 14638686] - Yuko Hirota, Naoko Masuyama, Toshio Kuronita, Hideaki Fujita, Masaru Himeno, Yoshitaka Tanaka. Analysis of post-lysosomal compartments.
Biochemical and biophysical research communications.
2004 Feb; 314(2):306-12. doi:
10.1016/j.bbrc.2003.12.092. [PMID: 14733906] - Jessie Zhang, Nicole Dudley-Rucker, Jan R Crowley, Elvira Lopez-Perez, Marc Issandou, Jean E Schaffer, Daniel S Ory. The steroidal analog GW707 activates the SREBP pathway through disruption of intracellular cholesterol trafficking.
Journal of lipid research.
2004 Feb; 45(2):223-31. doi:
10.1194/jlr.m300409-jlr200. [PMID: 14617742] - Atsushi Umeda, Hideaki Fujita, Toshio Kuronita, Kaori Hirosako, Masaru Himeno, Yoshitaka Tanaka. Distribution and trafficking of MPR300 is normal in cells with cholesterol accumulated in late endocytic compartments: evidence for early endosome-to-TGN trafficking of MPR300.
Journal of lipid research.
2003 Oct; 44(10):1821-32. doi:
10.1194/jlr.m300153-jlr200. [PMID: 12867541] - Bo Feng, Ira Tabas. ABCA1-mediated cholesterol efflux is defective in free cholesterol-loaded macrophages. Mechanism involves enhanced ABCA1 degradation in a process requiring full NPC1 activity.
The Journal of biological chemistry.
2002 Nov; 277(45):43271-80. doi:
10.1074/jbc.m207532200. [PMID: 12215451] - Iñaki de Diego, Felix Schwartz, Heide Siegfried, Paul Dauterstedt, Joerg Heeren, Ulrike Beisiegel, Carlos Enrich, Thomas Grewal. Cholesterol modulates the membrane binding and intracellular distribution of annexin 6.
The Journal of biological chemistry.
2002 Aug; 277(35):32187-94. doi:
10.1074/jbc.m205499200. [PMID: 12070178] - Toru Seo, Wanda Velez-Carrasco, Kemin Qi, Marni Hall, Tilla S Worgall, Rebecca A Johnson, Richard J Deckelbaum. Selective uptake from LDL is stimulated by unsaturated fatty acids and modulated by cholesterol content in the plasma membrane: role of plasma membrane composition in regulating non-SR-BI-mediated selective lipid transfer.
Biochemistry.
2002 Jun; 41(25):7885-94. doi:
10.1021/bi011949g. [PMID: 12069577] - Cécile Lebrand, Michela Corti, Holly Goodson, Pierre Cosson, Valeria Cavalli, Nathalie Mayran, Julien Fauré, Jean Gruenberg. Late endosome motility depends on lipids via the small GTPase Rab7.
The EMBO journal.
2002 Mar; 21(6):1289-300. doi:
10.1093/emboj/21.6.1289. [PMID: 11889035] - Yvonne Lange, Jin Ye, Mike Rigney, Theodore L Steck. Dynamics of lysosomal cholesterol in Niemann-Pick type C and normal human fibroblasts.
Journal of lipid research.
2002 Feb; 43(2):198-204. doi:
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Lipids.
2002 Jan; 37(1):53-9. doi:
10.1007/s11745-002-0863-9. [PMID: 11876263] - A Mohammadi, R J Perry, M K Storey, H W Cook, D M Byers, N D Ridgway. Golgi localization and phosphorylation of oxysterol binding protein in Niemann-Pick C and U18666A-treated cells.
Journal of lipid research.
2001 Jul; 42(7):1062-71. doi:
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Journal of cell science.
2001 May; 114(Pt 10):1893-900. doi:
10.1242/jcs.114.10.1893. [PMID: 11329376] - A Pol, R Luetterforst, M Lindsay, S Heino, E Ikonen, R G Parton. A caveolin dominant negative mutant associates with lipid bodies and induces intracellular cholesterol imbalance.
The Journal of cell biology.
2001 Mar; 152(5):1057-70. doi:
10.1083/jcb.152.5.1057. [PMID: 11238460] - D C Ko, M D Gordon, J Y Jin, M P Scott. Dynamic movements of organelles containing Niemann-Pick C1 protein: NPC1 involvement in late endocytic events.
Molecular biology of the cell.
2001 Mar; 12(3):601-14. doi:
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