Cholesterol hemisuccinate (BioDeep_00001028529)
代谢物信息卡片
4-[(3β)-Cholest-5-en-3-yloxy]-4-oxobutanoic acid
化学式: C31H50O4 (486.3709)
中文名称: 胆固醇琥珀酸单酯
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)OC(=O)CCC(=O)O)C)C
InChI: InChI=1S/C31H50O4/c1-20(2)7-6-8-21(3)25-11-12-26-24-10-9-22-19-23(35-29(34)14-13-28(32)33)15-17-30(22,4)27(24)16-18-31(25,26)5/h9,20-21,23-27H,6-8,10-19H2,1-5H3,(H,32,33)/t21-,23+,24+,25-,26+,27+,30+,31-/m1/s1
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
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Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
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PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Mohammad Mahmoudzadeh, Aniket Magarkar, Artturi Koivuniemi, Tomasz Róg, Alex Bunker. Mechanistic Insight into How PEGylation Reduces the Efficacy of pH-Sensitive Liposomes from Molecular Dynamics Simulations.
Molecular pharmaceutics.
2021 07; 18(7):2612-2621. doi:
10.1021/acs.molpharmaceut.1c00122. [PMID: 34096310] - Rafael Maldonado-Hernández, Orestes Quesada, José O Colón-Sáez, José A Lasalde-Dominicci. Sequential purification and characterization of Torpedo californica nAChR-DC supplemented with CHS for high-resolution crystallization studies.
Analytical biochemistry.
2020 12; 610(?):113887. doi:
10.1016/j.ab.2020.113887. [PMID: 32763308] - Bala M Xavier, Aiman A Zein, Angelica Venes, Junmei Wang, Jyh-Yeuan Lee. Transmembrane Polar Relay Drives the Allosteric Regulation for ABCG5/G8 Sterol Transporter.
International journal of molecular sciences.
2020 Nov; 21(22):. doi:
10.3390/ijms21228747. [PMID: 33228147] - Bozena Augustyn, Piotr Stepien, Chetan Poojari, Edouard Mobarak, Agnieszka Polit, Anna Wisniewska-Becker, Tomasz Róg. Cholesteryl Hemisuccinate Is Not a Good Replacement for Cholesterol in Lipid Nanodiscs.
The journal of physical chemistry. B.
2019 11; 123(46):9839-9845. doi:
10.1021/acs.jpcb.9b07853. [PMID: 31674185] - Lifeng Luo, Qiuyue Chen, Haoyu Gong, Lu Liu, Lingli Zhou, Haibing He, Yu Zhang, Tian Yin, Xing Tang. Capacity of cholesteryl hemisuccinate in ion pair/phospholipid complex to improve drug-loading, stability and antibacterial activity of clarithromycin intravenous lipid microsphere.
Colloids and surfaces. B, Biointerfaces.
2018 Dec; 172(?):262-271. doi:
10.1016/j.colsurfb.2018.08.038. [PMID: 30173093] - Manju Kanamala, Brian D Palmer, Hamidreza Ghandehari, William R Wilson, Zimei Wu. PEG-Benzaldehyde-Hydrazone-Lipid Based PEG-Sheddable pH-Sensitive Liposomes: Abilities for Endosomal Escape and Long Circulation.
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European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
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Lipids in health and disease.
2017 Dec; 16(1):242. doi:
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Langmuir : the ACS journal of surfaces and colloids.
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Journal of molecular modeling.
2014 Feb; 20(2):2121. doi:
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Molecular and cellular biochemistry.
2010 Jan; 333(1-2):137-49. doi:
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2008 Feb; 34(2):134-41. doi:
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Pharmacological research.
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Lipids.
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