A922500 (BioDeep_00001028521)

   


代谢物信息卡片


Cyclopentanecarboxylic acid, 2-((4-(((phenylamino)carbonyl)amino)(1,1-biphenyl)-4-yl)carbonyl)-, (1R,2R)-

化学式: C26H24N2O4 (428.1735984)
中文名称: DGAT-1 抑制剂
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1CC(C(C1)C(=O)O)C(=O)C2=CC=C(C=C2)C3=CC=C(C=C3)NC(=O)NC4=CC=CC=C4
InChI: InChI=1S/C26H24N2O4/c29-24(22-7-4-8-23(22)25(30)31)19-11-9-17(10-12-19)18-13-15-21(16-14-18)28-26(32)27-20-5-2-1-3-6-20/h1-3,5-6,9-16,22-23H,4,7-8H2,(H,30,31)(H2,27,28,32)/t22-,23-/m1/s1

描述信息

A 922500 (DGAT-1 Inhibitor 4a) is a potent, selective, and orally bioavailable diacylglycerol acyltransferase 1 (DGAT-1) inhibitor with IC50s of 9 and 22 nM against human and mouse DGAT-1, respectively.

同义名列表

4 个代谢物同义名

Cyclopentanecarboxylic acid, 2-((4-(((phenylamino)carbonyl)amino)(1,1-biphenyl)-4-yl)carbonyl)-, (1R,2R)-; A922500; DGAT-1 Inhibitor 4a; A 922500



数据库引用编号

5 个数据库交叉引用编号

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相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Jianwei Yan, Gaihong Wang, Xiangyu Dang, Binbin Guo, Wuhong Chen, Ting Wang, Limin Zeng, Heyao Wang, Youhong Hu. Discovery of a low-systemic-exposure DGAT-1 inhibitor with a picolinoylpyrrolidine-2-carboxylic acid moiety. Bioorganic & medicinal chemistry. 2017 09; 25(17):4701-4714. doi: 10.1016/j.bmc.2017.07.007. [PMID: 28739155]
  • Yunjeong Kim, David George, Allan M Prior, Keshar Prasain, Shuanghong Hao, Duy D Le, Duy H Hua, Kyeong-Ok Chang. Novel triacsin C analogs as potential antivirals against rotavirus infections. European journal of medicinal chemistry. 2012 Apr; 50(?):311-8. doi: 10.1016/j.ejmech.2012.02.010. [PMID: 22365411]
  • Hashim Motiwala, Shivaji Kandre, Vishal Birar, Kishorkumar S Kadam, Atish Rodge, Ravindra D Jadhav, M Mahesh Kumar Reddy, Manoja K Brahma, Nitin J Deshmukh, Amol Dixit, Lalit Doshi, Amol Gupte, Ashok K Gangopadhyay, Ram A Vishwakarma, Shaila Srinivasan, Mamta Sharma, Kumar V S Nemmani, Rajiv Sharma. Exploration of pyridine containing heteroaryl analogs of biaryl ureas as DGAT1 inhibitors. Bioorganic & medicinal chemistry letters. 2011 Oct; 21(19):5812-7. doi: 10.1016/j.bmcl.2011.07.109. [PMID: 21868220]
  • Andrew J King, Jason A Segreti, Kelly J Larson, Andrew J Souers, Philip R Kym, Regina M Reilly, Gang Zhao, Scott W Mittelstadt, Bryan F Cox. Diacylglycerol acyltransferase 1 inhibition lowers serum triglycerides in the Zucker fatty rat and the hyperlipidemic hamster. The Journal of pharmacology and experimental therapeutics. 2009 Aug; 330(2):526-31. doi: 10.1124/jpet.109.154047. [PMID: 19478132]
  • Gang Zhao, Andrew J Souers, Martin Voorbach, H Doug Falls, Brian Droz, Sevan Brodjian, Yau Yi Lau, Rajesh R Iyengar, Ju Gao, Andrew S Judd, Seble H Wagaw, Matthew M Ravn, Kenneth M Engstrom, John K Lynch, Mathew M Mulhern, Jennifer Freeman, Brian D Dayton, Xiaojun Wang, Nelson Grihalde, Dennis Fry, David W A Beno, Kennan C Marsh, Zhi Su, Gilbert J Diaz, Christine A Collins, Hing Sham, Regina M Reilly, Michael E Brune, Philip R Kym. Validation of diacyl glycerolacyltransferase I as a novel target for the treatment of obesity and dyslipidemia using a potent and selective small molecule inhibitor. Journal of medicinal chemistry. 2008 Feb; 51(3):380-3. doi: 10.1021/jm7013887. [PMID: 18183944]