Isometamidium chloride (BioDeep_00001028518)

   


代谢物信息卡片


Isometamidium chloride

化学式: C28H26ClN7 (495.19381060000006)
中文名称: 氯化氮氨菲啶
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC[N+]1=C2C=C(C=CC2=C3C=CC(=CC3=C1C4=CC=CC=C4)N=NNC5=CC=CC(=C5)C(=N)N)N.[Cl-]
InChI: 1H

描述信息

D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
C254 - Anti-Infective Agent > C276 - Antiparasitic Agent > C250 - Antihelminthic Agent

同义名列表

1 个代谢物同义名

Isometamidium chloride



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Dhanashree H Surve, Anil B Jindal. Development of cationic Isometamidium chloride loaded long-acting lipid nanoformulation: optimization, cellular uptake, pharmacokinetics, biodistribution, and immunohistochemical evaluation. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2021 Dec; 167(?):106024. doi: 10.1016/j.ejps.2021.106024. [PMID: 34592462]
  • J O Wesongah, G A Murilla, J K Kibugu, T W Jones. Evaluation of isometamidium levels in the serum of sheep and goats after prophylactic treatment against trypanosomosis. The Onderstepoort journal of veterinary research. 2004 Sep; 71(3):175-9. doi: 10.4102/ojvr.v71i3.257. [PMID: 15580765]
  • V Delespaux, S Geerts, J Brandt, R Elyn, M C Eisler. Monitoring the correct use of isometamidium by farmers and veterinary assistants in Eastern Province of Zambia using the isometamidium-ELISA. Veterinary parasitology. 2002 Dec; 110(1-2):117-22. doi: 10.1016/s0304-4017(02)00316-3. [PMID: 12446096]
  • D Olila, J J McDermott, M C Eisler, E S Mitema, R J Patzelt, P-H Clausen, C J Poetzsch, K-H Zessin, D Mehlitz, A S Peregrine. Drug sensitivity of trypanosome populations from cattle in a peri-urban dairy production system in Uganda. Acta tropica. 2002 Oct; 84(1):19-30. doi: 10.1016/s0001-706x(02)00137-7. [PMID: 12387907]
  • B F Ardelli, P T Woo. The in vitro effects of isometamidium chloride (Samorin) on the piscine hemoflagellate Cryptobia salmositica (Kinetoplastida, Bodonina). The Journal of parasitology. 2001 Feb; 87(1):194-202. doi: 10.1645/0022-3395(2001)087[0194:tiveoi]2.0.co;2. [PMID: 11227891]
  • B F Ardelli, P T Woo. An antigen-capture enzyme-linked immunosorbent assay (ELISA) to detect isometamidium chloride in Oncorhynchus spp. Diseases of aquatic organisms. 2000 Feb; 39(3):231-6. doi: 10.3354/dao039231. [PMID: 10768291]
  • B F Ardelli, P T Woo. The therapeutic use of isometamidium chloride against Cryptobia salmositica in rainbow trout Oncorhynchus mykiss. Diseases of aquatic organisms. 1999 Sep; 37(3):195-203. doi: 10.3354/dao037195. [PMID: 10546049]
  • M C Eisler, P Stevenson, L Munga, J B Smyth. Concentrations of isometamidium chloride (Samorin) in sera of Zebu cattle which showed evidence of hepatotoxicity following frequent trypanocidal treatments. Journal of veterinary pharmacology and therapeutics. 1997 Jun; 20(3):173-80. doi: 10.1111/j.1365-2885.1997.tb00092.x. [PMID: 9185082]
  • S Geerts, P Kageruka, R De Deken, J R Brandt, J M Kazadi, B Diarra, M C Eisler, Y Lemmouchi, E Schacht, P H Holmes. Prophylactic effects of isometamidium- and ethidium-sustained release devices against Trypanosoma congolense in cattle. Acta tropica. 1997 Apr; 65(1):23-31. doi: 10.1016/s0001-706x(97)00649-9. [PMID: 9140511]
  • M C Eisler, E A Gault, S K Moloo, P H Holmes, A S Peregrine. Concentrations of isometamidium in the sera of cattle challenged with drug-resistant Trypanosoma congolense. Acta tropica. 1997 Feb; 63(2-3):89-100. doi: 10.1016/s0001-706x(96)00602-x. [PMID: 9088422]
  • G A Murilla, R E Mdachi, W M Karanja. Pharmacokinetics, bioavailability and tissue residues of [14C]isometamidium in non-infected and Trypanosoma congolense-infected Boran cattle. Acta tropica. 1996 Aug; 61(4):277-92. doi: 10.1016/0001-706x(96)00010-1. [PMID: 8910653]
  • M C Eisler, C T Elliott, P H Holmes. A simple competitive enzyme immunoassay for the detection of the trypanocidal drug isometamidium. Therapeutic drug monitoring. 1996 Feb; 18(1):73-9. doi: 10.1097/00007691-199602000-00012. [PMID: 8848825]
  • J M Wilkes, A S Peregrine, D Zilberstein. The accumulation and compartmentalization of isometamidium chloride in Trypanosoma congolense, monitored by its intrinsic fluorescence. The Biochemical journal. 1995 Nov; 312 ( Pt 1)(?):319-27. doi: 10.1042/bj3120319. [PMID: 7492332]
  • A S Peregrine, M C Eisler, J Katende, J N Flynn, E A Gault, L D Kinabo, P H Holmes. Generation of monoclonal antibodies to the anti-trypanosomal drug isometamidium. Hybridoma. 1994 Aug; 13(4):289-94. doi: 10.1089/hyb.1994.13.289. [PMID: 7806249]
  • R Kaminsky, F Chuma, R P Wasike. Time-dose response of Trypanosoma congolense bloodstream forms to diminazene and isometamidium. Veterinary parasitology. 1994 Apr; 52(3-4):235-42. doi: 10.1016/0304-4017(94)90115-5. [PMID: 8073607]
  • M C Eisler, R O Arowolo, E A Gault, S K Moloo, P H Holmes, A S Peregrine. Isometamidium concentrations in the sera of Boran cattle: correlation with prophylaxis against tsetse-transmitted Trypanosoma congolense. Acta tropica. 1994 Feb; 56(1):39-50. doi: 10.1016/0001-706x(94)90038-8. [PMID: 8203294]
  • M C Eisler, E A Gault, H V Smith, A S Peregrine, P H Holmes. Evaluation and improvement of an enzyme-linked immunosorbent assay for the detection of isometamidium in bovine serum. Therapeutic drug monitoring. 1993 Jun; 15(3):236-42. doi: 10.1097/00007691-199306000-00010. [PMID: 8333004]
  • D Zilberstein, J Wilkes, H Hirumi, A S Peregrine. Fluorescence analysis of the interaction of isometamidium with Trypanosoma congolense. The Biochemical journal. 1993 May; 292 ( Pt 1)(?):31-5. doi: 10.1042/bj2920031. [PMID: 8503859]
  • E Katunguka-Rwakishaya, J J Parkins, G Fishwick, M Murray, P H Holmes. The pathophysiology of Trypanosoma congolense infection in Scottish blackface sheep. Influence of dietary protein. Veterinary parasitology. 1993 May; 47(3-4):189-204. doi: 10.1016/0304-4017(93)90021-e. [PMID: 8333126]
  • D D Whitelaw, E A Gault, P H Holmes, I A Sutherland, F J Rowell, A Phillips, G M Urquhart. Development of an enzyme-linked immunosorbent assay for the detection and measurement of the trypanocidal drug isometamidium chloride in cattle. Research in veterinary science. 1991 Mar; 50(2):185-9. doi: 10.1016/0034-5288(91)90103-u. [PMID: 2034897]
  • L D Kinabo, Q A McKellar, P D Eckersall. Isometamidium in pigs: disposition kinetics, tissue residues and adverse reactions. Research in veterinary science. 1991 Jan; 50(1):6-13. doi: 10.1016/0034-5288(91)90045-p. [PMID: 2047593]
  • L D Kinabo, Q A McKellar. Isometamidium in goats: disposition kinetics, mammary excretion and tissue residues. The British veterinary journal. 1990 Sep; 146(5):405-12. doi: 10.1016/0007-1935(90)90028-2. [PMID: 2224485]
  • C A Ross, A M Taylor. Trypanosoma congolense: an in vitro assay to distinguish drug-resistant from drug-sensitive populations. Parasitology research. 1990; 76(4):326-31. doi: 10.1007/bf00928187. [PMID: 2336447]
  • R Kaminsky, I D Gumm, E Zweygarth, F Chuma. A drug incubation infectivity test (DIIT) for assessing resistance in trypanosomes. Veterinary parasitology. 1990 Jan; 34(4):335-43. doi: 10.1016/0304-4017(90)90079-q. [PMID: 2316178]
  • R Brun, C Kunz. In vitro drug sensitivity test for Trypanosoma brucei subgroup bloodstream trypomastigotes. Acta tropica. 1989 Oct; 46(5-6):361-8. doi: 10.1016/0001-706x(89)90048-x. [PMID: 2575871]
  • L D Kinabo, J A Bogan, Q A McKellar, M Murray. Relay bioavailability and toxicity of isometamidium residues: a model for human risk assessment. Veterinary and human toxicology. 1989 Oct; 31(5):417-21. doi: NULL. [PMID: 2603360]
  • L D Kinabo, J A Bogan. Solid-phase extraction and ion-pair reversed-phase HPLC of isometamidium in bovine serum and tissues. Acta tropica. 1988 Jun; 45(2):165-70. doi: NULL. [PMID: 2901203]
  • L D Kinabo, J A Bogan. Pharmacokinetic and histopathological investigations of isometamidium in cattle. Research in veterinary science. 1988 Mar; 44(2):267-9. doi: 10.1016/s0034-5288(18)30855-5. [PMID: 3387683]
  • L D Kinabo, J A Bogan. Development of a radioimmunoassay for isometamidium. Veterinary research communications. 1988; 12(4-5):375-82. doi: 10.1007/bf00343258. [PMID: 3195050]
  • B H Ali, T Hassan. Some observations on the toxicosis of isometamidium chloride (samorin) in camels. Veterinary and human toxicology. 1986 Oct; 28(5):424-6. doi: NULL. [PMID: 3776085]
  • N K Borowy, E Fink, H Hirumi. Trypanosoma brucei: five commonly used trypanocides assayed in vitro with a mammalian feeder layer system for cultivation of bloodstream forms. Experimental parasitology. 1985 Dec; 60(3):323-30. doi: 10.1016/0014-4894(85)90038-4. [PMID: 4076388]
  • H Perschke, L Vollner. Determination of the trypanocidal drugs homidium, isometamidium and quinapyramine in bovine serum or plasma using HPLC. Acta tropica. 1985 Sep; 42(3):209-16. doi: . [PMID: 2865876]
  • B H Ali, T Hassan. Preliminary pharmacokinetic study of isometamidium chloride in camels. Research in veterinary science. 1984 Nov; 37(3):376-7. doi: 10.1016/s0034-5288(18)31888-5. [PMID: 6522836]
  • B H Ali, E M Haroun. Acute toxicity of samorin (isometamidium chloride) in rabbits. Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology. 1984; 78(2):419-23. doi: 10.1016/0742-8413(84)90109-9. [PMID: 6149091]
  • F W Jennings, G D Gray. The possible use of Trypanosoma musculi infection in mice as a screening test for potential Trypanosoma cruzi-active drugs. Zeitschrift fur Parasitenkunde (Berlin, Germany). 1982; 67(3):245-8. doi: 10.1007/bf00927658. [PMID: 6814086]
  • V B Braide, K I Eghianruwa. Isometamidium residues in goat tissues after parenteral administration. Research in veterinary science. 1980 Jul; 29(1):111-3. doi: 10.1016/s0034-5288(18)32697-3. [PMID: 7455341]
  • P Girgis-Takla, D M James. In vitro uptake of isometamidium and diminazene by Trypanosoma brucei. Antimicrobial agents and chemotherapy. 1974 Sep; 6(3):372-4. doi: 10.1128/aac.6.3.372. [PMID: 15830490]