Iron citrate (BioDeep_00001028470)
代谢物信息卡片
Iron citrate
化学式: C6H8FeO7 (247.96194079999998)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(C(=O)O)C(CC(=O)O)(C(=O)O)O.[Fe]
InChI: /h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)
描述信息
D006401 - Hematologic Agents > D006397 - Hematinics > D005290 - Ferric Compounds
同义名列表
1 个代谢物同义名
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
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Plant Reactome(0)
INOH(0)
PlantCyc(0)
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PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Keitaro Yokoyama, Teruo Hashimoto, Yuri Okuda, Yu Matsumoto, Kyoko Ito, Ryoichi Yamada, Hiroyuki Susai, Noriaki Nishino. Safety and effectiveness of ferric citrate hydrate in serum phosphorus management of patients with chronic kidney disease: a long-term, real-world, observational, post-marketing surveillance study.
Clinical and experimental nephrology.
2022 Jul; 26(7):688-699. doi:
10.1007/s10157-022-02204-1. [PMID: 35258721] - Arwen E Frick-Cheng, Anna Sintsova, Sara N Smith, Ali Pirani, Evan S Snitkin, Harry L T Mobley. Ferric Citrate Uptake Is a Virulence Factor in Uropathogenic Escherichia coli.
mBio.
2022 06; 13(3):e0103522. doi:
10.1128/mbio.01035-22. [PMID: 35546538] - Michael P Liesen, Megan L Noonan, Pu Ni, Rafiou Agoro, Julia M Hum, Erica L Clinkenbeard, John G Damrath, Joseph M Wallace, Elizabeth A Swallow, Matthew R Allen, Kenneth E White. Segregating the effects of ferric citrate-mediated iron utilization and FGF23 in a mouse model of CKD.
Physiological reports.
2022 06; 10(11):e15307. doi:
10.14814/phy2.15307. [PMID: 35656701] - Mark R Hanudel, Brian Czaya, Shirley Wong, Grace Jung, Kristine Chua, Bo Qiao, Victoria Gabayan, Tomas Ganz. Renoprotective effects of ferric citrate in a mouse model of chronic kidney disease.
Scientific reports.
2022 04; 12(1):6695. doi:
10.1038/s41598-022-10842-4. [PMID: 35461329] - Mark R Hanudel, Brian Czaya, Shirley Wong, Maxime Rappaport, Shweta Namjoshi, Kristine Chua, Grace Jung, Victoria Gabayan, Bo Qiao, Elizabeta Nemeth, Tomas Ganz. Enteral ferric citrate absorption is dependent on the iron transport protein ferroportin.
Kidney international.
2022 04; 101(4):711-719. doi:
10.1016/j.kint.2021.10.036. [PMID: 34838540] - Volker H Haase. The ins and outs of ferric citrate.
Kidney international.
2022 04; 101(4):668-670. doi:
10.1016/j.kint.2021.12.032. [PMID: 35314048] - Tadashi Yoshida, Kohkichi Morimoto, Noriko Kaburagi, Teppei Fujino, Tomoko Yamashita Takemitsu, Norimasa Yamashita, Mototsugu Oya. Long-term efficacy and safety of iron-based phosphate binders, ferric citrate hydrate and sucroferric oxyhydroxide, in hemodialysis patients.
International urology and nephrology.
2022 Apr; 54(4):861-872. doi:
10.1007/s11255-021-02952-1. [PMID: 34264473] - Kyoko Ito, Keitaro Yokoyama, Masaaki Nakayama, Masafumi Fukagawa, Hideki Hirakata. Ferric citrate hydrate is associated with a reduced cost of drugs and a smaller change in red blood cell distribution width.
Scientific reports.
2022 02; 12(1):2406. doi:
10.1038/s41598-022-06261-0. [PMID: 35165297] - Chien-Te Lee, Chin-Chan Lee, Ming-Ju Wu, Yi-Wen Chiu, Jyh-Gang Leu, Ming-Shiou Wu, Yu-Sen Peng, Mai-Szu Wu, Der-Cherng Tarng. Long-term safety and efficacy of ferric citrate in phosphate-lowering and iron-repletion effects among patients with on hemodialysis: A multicenter, open-label, Phase IV trial.
PloS one.
2022; 17(3):e0264727. doi:
10.1371/journal.pone.0264727. [PMID: 35239732] - Nicole M Lioufas, Elaine M Pascoe, Carmel M Hawley, Grahame J Elder, Sunil V Badve, Geoffrey A Block, David W Johnson, Nigel D Toussaint. Systematic Review and Meta-Analyses of the Effects of Phosphate-Lowering Agents in Nondialysis CKD.
Journal of the American Society of Nephrology : JASN.
2022 01; 33(1):59-76. doi:
10.1681/asn.2021040554. [PMID: 34645696] - Kyoko Ito, Keitaro Yokoyama, Masaaki Nakayama, Masafumi Fukagawa, Hideki Hirakata. Association of fibroblast growth factor 23 and α-klotho in hemodialysis patients during administration of ferric citrate hydrate: post hoc analysis of ASTRIO study.
BMC nephrology.
2021 11; 22(1):374. doi:
10.1186/s12882-021-02575-9. [PMID: 34758731] - Yan Zhu, Jinlan Rao, Xueling Liao, Jihong Ou, Wei Li, Chao Xue. Using iron-based phosphate binders in phosphate reduction and anemia improvement in patients receiving dialysis: a meta-analysis of randomized controlled trials.
International urology and nephrology.
2021 Sep; 53(9):1899-1909. doi:
10.1007/s11255-021-02820-y. [PMID: 33675476] - Qihui Luo, Chengjie Lao, Chao Huang, Yu Xia, Wenjing Ma, Wentao Liu, Zhengli Chen. Iron Overload Resulting from the Chronic Oral Administration of Ferric Citrate Impairs Intestinal Immune and Barrier in Mice.
Biological trace element research.
2021 Mar; 199(3):1027-1036. doi:
10.1007/s12011-020-02218-4. [PMID: 32468223] - Yeo Jin Choi, Yoojin Noh, Sooyoung Shin. Ferric citrate in the management of hyperphosphataemia and iron deficiency anaemia: A meta-analysis in patients with chronic kidney disease.
British journal of clinical pharmacology.
2021 02; 87(2):414-426. doi:
10.1111/bcp.14396. [PMID: 32470149] - Pablo E Pergola, Diogo Belo, Paul Crawford, Moustafa Moustafa, Wenli Luo, Alexander Goldfarb-Rumyantzev, Youssef M K Farag. Ferric Citrate Dosing in Iron Deficiency Anemia in Nondialysis-Dependent Chronic Kidney Disease.
American journal of nephrology.
2021; 52(7):572-581. doi:
10.1159/000516012. [PMID: 34293738] - Hitoshi Minakuchi, Tadashi Yoshida, Noriko Kaburagi, Teppei Fujino, Sho Endo, Tomoko Yamashita Takemitsu, Norimasa Yamashita, Hiroshi Itoh, Mototsugu Oya. Proton pump inhibitors may hinder hypophosphatemic effect of lanthanum carbonate, but not of ferric citrate hydrate or sucroferric oxyhydroxide, in hemodialysis patients.
Renal failure.
2020 Nov; 42(1):799-806. doi:
10.1080/0886022x.2020.1803085. [PMID: 32779954] - Rebecca Womack, Fabian Berru, Bhupesh Panwar, Orlando M Gutiérrez. Effect of Ferric Citrate versus Ferrous Sulfate on Iron and Phosphate Parameters in Patients with Iron Deficiency and CKD: A Randomized Trial.
Clinical journal of the American Society of Nephrology : CJASN.
2020 09; 15(9):1251-1258. doi:
10.2215/cjn.15291219. [PMID: 32694162] - Nosratola D Vaziri, Ane C F Nunes, Hyder Said, Mahyar Khazaeli, Han Liu, Yitong Zhao, Wanghui Jing, Kyle Cogburn, Leila Alikhani, Wei Ling Lau. Route of intestinal absorption and tissue distribution of iron contained in the novel phosphate binder ferric citrate.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2020 07; 35(7):1136-1144. doi:
10.1093/ndt/gfaa053. [PMID: 32514572] - Jürgen Floege, Felix Funk, Markus Ketteler, Anjay Rastogi, Sebastian Walpen, Adrian C Covic, Stuart M Sprague. Iron kinetics following treatment with sucroferric oxyhydroxide or ferric citrate in healthy rats and models of anaemia, iron overload or inflammation.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2020 06; 35(6):946-954. doi:
10.1093/ndt/gfaa030. [PMID: 32259248] - Nabeel Aslam, Maulik Govani, Luke M Basdeo, Hani M Wadei. Can ferric citrate lead to iron overload in peritoneal dialysis patients?
.
Clinical nephrology.
2020 May; 93(5):262-266. doi:
10.5414/cn109738. [PMID: 31933474] - Akio Iida, Mutsuyoshi Matsushita, Takeshi Ohta, Takahisa Yamada. Conventional and novel impacts of ferric citrate on iron deficiency anemia and phosphorus metabolism in rats.
The Journal of veterinary medical science.
2020 Mar; 82(3):379-386. doi:
10.1292/jvms.19-0641. [PMID: 31996496] - Seyyed Mehdy Elahi, Chun Fang Shen, Rénald Gilbert. Impact of dextran sulfate in culture media on titration of vesicular stomatitis virus.
Journal of virological methods.
2020 01; 275(?):113758. doi:
10.1016/j.jviromet.2019.113758. [PMID: 31678047] - Connor Francis, Guillaume Courbon, Claire Gerber, Samantha Neuburg, Xueyan Wang, Corey Dussold, Maralee Capella, Lixin Qi, Tamara Isakova, Rupal Mehta, Aline Martin, Myles Wolf, Valentin David. Ferric citrate reduces fibroblast growth factor 23 levels and improves renal and cardiac function in a mouse model of chronic kidney disease.
Kidney international.
2019 12; 96(6):1346-1358. doi:
10.1016/j.kint.2019.07.026. [PMID: 31668632] - Mark R Hanudel. Ferric citrate: cardio- and renoprotective in chronic kidney disease?.
Kidney international.
2019 12; 96(6):1277-1279. doi:
10.1016/j.kint.2019.09.004. [PMID: 31759486] - Paola Ciceri, Monica Falleni, Delfina Tosi, Carla Martinelli, Stefania Cannizzo, Giulia Marchetti, Antonella D'Arminio Monforte, Gaetano Bulfamante, Geoffrey A Block, Piergiorgio Messa, Mario Cozzolino. Therapeutic Effect of Iron Citrate in Blocking Calcium Deposition in High Pi-Calcified VSMC: Role of Autophagy and Apoptosis.
International journal of molecular sciences.
2019 Nov; 20(23):. doi:
10.3390/ijms20235925. [PMID: 31775364] - Shuanglong Wang, Laurent Ouerdane, Owen Hoekenga, Joanna Szpunar, Ryszard Lobinski. Mass spectrometry-based analytical developments to link iron speciation to iron bioavailability in maize.
Food chemistry.
2019 Oct; 294(?):414-422. doi:
10.1016/j.foodchem.2019.05.014. [PMID: 31126482] - Masaki Hara, Yuya Nakamura, Hiroki Suzuki, Rin Asao, Masayuki Nakamura, Kazumasa Nishida, Sachiyo Kenmotsu, Masahiro Inagaki, Mayumi Tsuji, Yuji Kiuchi, Isao Ohsawa, Yoshikazu Goto, Hiromichi Gotoh. Hepcidin-25/erythroferrone ratio predicts improvement of anaemia in haemodialysis patients treated with ferric citrate hydrate.
Nephrology (Carlton, Vic.).
2019 Aug; 24(8):819-826. doi:
10.1111/nep.13495. [PMID: 30239062] - Geoffrey A Block, Martha S Block, Gerard Smits, Rupal Mehta, Tamara Isakova, Myles Wolf, Glenn M Chertow. A Pilot Randomized Trial of Ferric Citrate Coordination Complex for the Treatment of Advanced CKD.
Journal of the American Society of Nephrology : JASN.
2019 08; 30(8):1495-1504. doi:
10.1681/asn.2018101016. [PMID: 31278194] - Geoffrey A Block, Pablo E Pergola, Steven Fishbane, Julian G Martins, Robin D LeWinter, Katrin Uhlig, John F Neylan, Glenn M Chertow. Effect of ferric citrate on serum phosphate and fibroblast growth factor 23 among patients with nondialysis-dependent chronic kidney disease: path analyses.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2019 07; 34(7):1115-1124. doi:
10.1093/ndt/gfy318. [PMID: 30380116] - Pablo E Pergola, Steven Fishbane, Tomas Ganz. Novel Oral Iron Therapies for Iron Deficiency Anemia in Chronic Kidney Disease.
Advances in chronic kidney disease.
2019 07; 26(4):272-291. doi:
10.1053/j.ackd.2019.05.002. [PMID: 31477258] - Keitaro Yokoyama, Masafumi Fukagawa, Takashi Akiba, Masaaki Nakayama, Kyoko Ito, Koji Hanaki, Myles Wolf, Hideki Hirakata. Randomised clinical trial of ferric citrate hydrate on anaemia management in haemodialysis patients with hyperphosphataemia: ASTRIO study.
Scientific reports.
2019 06; 9(1):8877. doi:
10.1038/s41598-019-45335-4. [PMID: 31222044] - Hiroaki Amano, Yoichi Ohno, Tsutomu Inoue, Koji Tomori, Kazuya Ohama, Hirokazu Okada. Regional prescription surveillance of phosphate binders in the western Saitama area: the substantial role of ferric citrate hydrate in improving serum phosphorus levels and erythropoiesis.
Clinical and experimental nephrology.
2019 Jun; 23(6):841-851. doi:
10.1007/s10157-019-01715-8. [PMID: 30783915] - Tomas Ganz, Avi Bino, Isidro B Salusky. Mechanism of Action and Clinical Attributes of Auryxia® (Ferric Citrate).
Drugs.
2019 Jun; 79(9):957-968. doi:
10.1007/s40265-019-01125-w. [PMID: 31134521] - Nitya Nand, Kajaree Giri, Deepak Jain. Role of Ferric Citrate in Hyperphosphatemia and Iron Deficiency Anemia in Non Dialysis CKD Patients.
The Journal of the Association of Physicians of India.
2019 Apr; 67(4):53-56. doi:
. [PMID: 31311220] - Masaki Goto, Yasunori Suematsu, Ane C F Nunes, Wanghui Jing, Mahyar Khazaeli, Wei Ling Lau, Nosratola D Vaziri. Ferric Citrate Attenuates Cardiac Hypertrophy and Fibrosis in a Rat Model of Chronic Kidney Disease.
Iranian journal of kidney diseases.
2019 03; 13(2):98-104. doi:
NULL. [PMID: 30988246] - Nobuo Nagano, Ayako Minegishi, Kyoko Ito, Tetsuo Ando, Takaaki Tsutsui, Tetsuya Ogawa. Phosphate Binders Derived from Natural Ores Contain Many Kinds of Metallic Elements Besides Their Active Ingredient Metals.
Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy.
2018 Dec; 22(6):630-634. doi:
10.1111/1744-9987.12704. [PMID: 29989312] - Wei Ling Lau, Nosratola D Vaziri, Ane C F Nunes, André M Comeau, Morgan G I Langille, Whitney England, Mahyar Khazaeli, Yasunori Suematsu, Joann Phan, Katrine Whiteson. The Phosphate Binder Ferric Citrate Alters the Gut Microbiome in Rats with Chronic Kidney Disease.
The Journal of pharmacology and experimental therapeutics.
2018 12; 367(3):452-460. doi:
10.1124/jpet.118.251389. [PMID: 30287477] - Mark R Hanudel, Marciana Laster, Georgina Ramos, Barbara Gales, Isidro B Salusky. Clinical experience with the use of ferric citrate as a phosphate binder in pediatric dialysis patients.
Pediatric nephrology (Berlin, Germany).
2018 11; 33(11):2137-2142. doi:
10.1007/s00467-018-3999-y. [PMID: 29956006] - S E G van Raaij, R Masereeuw, D W Swinkels, R P L van Swelm. Inhibition of Nrf2 alters cell stress induced by chronic iron exposure in human proximal tubular epithelial cells.
Toxicology letters.
2018 Oct; 295(?):179-186. doi:
10.1016/j.toxlet.2018.06.1218. [PMID: 29959986] - Wanghui Jing, Ane C F Nunes, Ted Farzaneh, Mahyar Khazaeli, Wei Ling Lau, Nosratola D Vaziri. Phosphate Binder, Ferric Citrate, Attenuates Anemia, Renal Dysfunction, Oxidative Stress, Inflammation, and Fibrosis in 5/6 Nephrectomized CKD Rats.
The Journal of pharmacology and experimental therapeutics.
2018 10; 367(1):129-137. doi:
10.1124/jpet.118.249961. [PMID: 30093458] - Peter A McCullough, Katrin Uhlig, John F Neylan, Pablo E Pergola, Steven Fishbane. Usefulness of Oral Ferric Citrate in Patients With Iron-Deficiency Anemia and Chronic Kidney Disease With or Without Heart Failure.
The American journal of cardiology.
2018 08; 122(4):683-688. doi:
10.1016/j.amjcard.2018.04.062. [PMID: 29961562] - Akira Iguchi, Suguru Yamamoto, Mihoko Yamazaki, Kazuyuki Tasaki, Yasushi Suzuki, Junichiro James Kazama, Ichiei Narita. Effect of ferric citrate hydrate on FGF23 and PTH levels in patients with non-dialysis-dependent chronic kidney disease with normophosphatemia and iron deficiency.
Clinical and experimental nephrology.
2018 Aug; 22(4):789-796. doi:
10.1007/s10157-017-1510-x. [PMID: 29181658] - Nathaniel Dziuba, Joanne Hardy, Paul A Lindahl. Low-molecular-mass iron in healthy blood plasma is not predominately ferric citrate.
Metallomics : integrated biometal science.
2018 06; 10(6):802-817. doi:
10.1039/c8mt00055g. [PMID: 29808889] - Pablo E Pergola, Steven Fishbane, Robin D LeWinter, John F Neylan, Katrin Uhlig, Geoffrey A Block, Glenn M Chertow. Hemoglobin response to ferric citrate in patients with nondialysis-dependent chronic kidney disease and iron deficiency anemia.
American journal of hematology.
2018 06; 93(6):E154-E156. doi:
10.1002/ajh.25088. [PMID: 29575100] - Noriaki Maruyama, Tomoyasu Otsuki, Yoshinori Yoshida, Chinami Nagura, Maki Kitai, Nami Shibahara, Hyoe Tomita, Takashi Maruyama, Masanori Abe. Ferric Citrate Decreases Fibroblast Growth Factor 23 and Improves Erythropoietin Responsiveness in Hemodialysis Patients.
American journal of nephrology.
2018; 47(6):406-414. doi:
10.1159/000489964. [PMID: 29874654] - Ting-Yun Chang, Kai-Li Liu, Cheng Sheng Chang, Chien-Tien Su, Seu-Hwa Chen, Yu-Chieh Lee, Jung-Su Chang. Ferric Citrate Supplementation Reduces Red-Blood-Cell Aggregation and Improves CD163+ Macrophage-Mediated Hemoglobin Metabolism in a Rat Model of High-Fat-Diet-Induced Obesity.
Molecular nutrition & food research.
2018 01; 62(2):. doi:
10.1002/mnfr.201700442. [PMID: 29064631] - Francesco Locatelli, Lucia Del Vecchio. Iron-based phosphate binders: a paradigm shift in the treatment of hyperphosphatemic anemic CKD patients?.
Journal of nephrology.
2017 Dec; 30(6):755-765. doi:
10.1007/s40620-017-0421-y. [PMID: 28717990] - Pan Li, Binbin Zhou, Xiaomin Cao, Xianghu Tang, Liangbao Yang, Ling Hu, Jinhuai Liu. Functionalized Acupuncture Needle as Surface-Enhanced Resonance Raman Spectroscopy Sensor for Rapid and Sensitive Detection of Dopamine in Serum and Cerebrospinal Fluid.
Chemistry (Weinheim an der Bergstrasse, Germany).
2017 Oct; 23(57):14278-14285. doi:
10.1002/chem.201702607. [PMID: 28722332] - Karen Rascati. Comment on: 'Net Budgetary Impact of Ferric Citrate as a First-Line Phosphate Binder for the Treatment of Hyperphosphatemia: A Markov Microsimulation Mode'.
Drugs in R&D.
2017 09; 17(3):487-488. doi:
10.1007/s40268-017-0185-9. [PMID: 28528515] - Hao Wang, Peng An, Enjun Xie, Qian Wu, Xuexian Fang, Hong Gao, Zhuzhen Zhang, Yuzhu Li, Xudong Wang, Jiaying Zhang, Guoli Li, Lei Yang, Wei Liu, Junxia Min, Fudi Wang. Characterization of ferroptosis in murine models of hemochromatosis.
Hepatology (Baltimore, Md.).
2017 08; 66(2):449-465. doi:
10.1002/hep.29117. [PMID: 28195347] - Debra J Hain, Meredith Marinaro, David W Koeper, Melissa A Rosenthal, Salvatore Chillemi, Jennifer M Huffman, Teresa Gerbeling, James M Pritsiolas, Lisa C Loram, Pablo E Pergola. Ferric citrate controls serum phosphorus in dialysis patients: retrospective data
.
Clinical nephrology.
2017 Jul; 88(1):12-18. doi:
10.5414/cn109057. [PMID: 28561732] - Diana Jalal, Molly McFadden, Jamie P Dwyer, Kausik Umanath, Erwin Aguilar, Yoram Yagil, Barbara Greco, Mohammed Sika, Julia B Lewis, Tom Greene, Simin Goral. Adherence rates to ferric citrate as compared to active control in patients with end stage kidney disease on dialysis.
Hemodialysis international. International Symposium on Home Hemodialysis.
2017 04; 21(2):243-249. doi:
10.1111/hdi.12487. [PMID: 27615161] - Glenn M Chertow, Geoffrey A Block, John F Neylan, Pablo E Pergola, Katrin Uhlig, Steven Fishbane. Safety and efficacy of ferric citrate in patients with nondialysis-dependent chronic kidney disease.
PloS one.
2017; 12(11):e0188712. doi:
10.1371/journal.pone.0188712. [PMID: 29186198] - Takeshi Nakanishi, Yukiko Hasuike, Masayoshi Nanami, Mana Yahiro, Takahiro Kuragano. Novel iron-containing phosphate binders and anemia treatment in CKD: oral iron intake revisited.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2016 10; 31(10):1588-94. doi:
10.1093/ndt/gfv268. [PMID: 26142396] - Mario Cozzolino, Michela Mangano, Lorenza Magagnoli, Luca Di Lullo, Andrea Galassi, Diego Brancaccio, Antonio Bellasi. [Iron-based Phosphate Binders for ESRD Patients].
Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia.
2016 Jul; 33(4):. doi:
NULL. [PMID: 27545638] - A Yaguchi, S Yonekubo, I Maruyama, S Tatemichi, K Maruyama, M Kobayashi. Comparison of Phosphate Binding Capacities of PA21, A Novel Phosphate Binder, with those of other Phosphate Binders in vitro and in vivo.
Drug research.
2016 May; 66(5):262-9. doi:
10.1055/s-0035-1569328. [PMID: 26761712] - Geoffrey A Block. Ferric Citrate in Patients With Chronic Kidney Disease.
Seminars in nephrology.
2016 03; 36(2):130-5. doi:
10.1016/j.semnephrol.2016.02.008. [PMID: 27236135] - Hitesh H Shah, Azzour D Hazzan, Steven Fishbane. Ferric Pyrophosphate Citrate: A Novel Iron Replacement Agent in Patients Undergoing Hemodialysis.
Seminars in nephrology.
2016 03; 36(2):124-9. doi:
10.1016/j.semnephrol.2016.02.007. [PMID: 27236134] - Nosratola D Vaziri. Safety Issues in Iron Treatment in CKD.
Seminars in nephrology.
2016 03; 36(2):112-8. doi:
10.1016/j.semnephrol.2016.02.005. [PMID: 27236132] - Keitaro Yokoyama. [Phosphate metabolism and iron deficiency].
Clinical calcium.
2016 Feb; 26(2):241-9. doi:
clica1602241249. [PMID: 26813504] - Yuko Iwashita, Yu Iwashita, Takafumi Ito, Takashi Shigematsu. [Treatment for CKD-MBD(Chronic Kidney Disease-Mineral and Bone Disorder)].
Clinical calcium.
2016 Feb; 26(2):259-67. doi:
clica1602259267. [PMID: 26813506] - Motoko Tanaka, Shigeyuki Miyamura, Tadashi Imafuku, Yuna Tominaga, Hitoshi Maeda, Makoto Anraku, Keishi Yamasaki, Daisuke Kadowaki, Yu Ishima, Hiroshi Watanabe, Tomoko Okuda, Kazuko Itoh, Kazutaka Matsushita, Masafumi Fukagawa, Masaki Otagiri, Toru Maruyama. Effect of a Ferric Citrate Formulation, a Phosphate Binder, on Oxidative Stress in Chronic Kidney Diseases-Mineral and Bone Disorder Patients Receiving Hemodialysis: A Pilot Study.
Biological & pharmaceutical bulletin.
2016; 39(6):1000-6. doi:
10.1248/bpb.b15-01021. [PMID: 27251502] - Amy Barton Pai, Soo Min Jang, Nicole Wegrzyn. Iron-based phosphate binders--a new element in management of hyperphosphatemia.
Expert opinion on drug metabolism & toxicology.
2016; 12(1):115-27. doi:
10.1517/17425255.2016.1110573. [PMID: 26572591] - Steven N Fishbane, Ajay K Singh, Serge H Cournoyer, Kailash K Jindal, Paolo Fanti, Carrie D Guss, Vivian H Lin, Raymond D Pratt, Ajay Gupta. Ferric pyrophosphate citrate (Triferic™) administration via the dialysate maintains hemoglobin and iron balance in chronic hemodialysis patients.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2015 Dec; 30(12):2019-26. doi:
10.1093/ndt/gfv277. [PMID: 26175145] - Kausik Umanath, Diana I Jalal, Barbara A Greco, Ebele M Umeukeje, Efrain Reisin, John Manley, Steven Zeig, Dana G Negoi, Anand N Hiremath, Samuel S Blumenthal, Mohammed Sika, Robert Niecestro, Mark J Koury, Khe-Ni Ma, Tom Greene, Julia B Lewis, Jamie P Dwyer. Ferric Citrate Reduces Intravenous Iron and Erythropoiesis-Stimulating Agent Use in ESRD.
Journal of the American Society of Nephrology : JASN.
2015 Oct; 26(10):2578-87. doi:
10.1681/asn.2014080842. [PMID: 25736045] - Peter N Van Buren, Julia B Lewis, Jamie P Dwyer, Tom Greene, John Middleton, Mohammed Sika, Kausik Umanath, Josephine D Abraham, Shahabul S Arfeen, Isai G Bowline, Gil Chernin, Stephen Z Fadem, Simin Goral, Mark Koury, Marvin V Sinsakul, Daniel E Weiner. The Phosphate Binder Ferric Citrate and Mineral Metabolism and Inflammatory Markers in Maintenance Dialysis Patients: Results From Prespecified Analyses of a Randomized Clinical Trial.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
2015 Sep; 66(3):479-88. doi:
10.1053/j.ajkd.2015.03.013. [PMID: 25958079] - Roger A Rodby, Kausik Umanath, Robert Niecestro, T Christopher Bond, Mohammed Sika, Julia Lewis, Jamie P Dwyer. Ferric Citrate, an Iron-Based Phosphate Binder, Reduces Health Care Costs in Patients on Dialysis Based on Randomized Clinical Trial Data.
Drugs in R&D.
2015 Sep; 15(3):271-9. doi:
10.1007/s40268-015-0103-y. [PMID: 26239948] - Roger Rodby, Kausik Umanath, Robert Niecestro, James H Jackson, Mohammed Sika, Julia B Lewis, Jamie P Dwyer. Phosphorus binding with ferric citrate is associated with fewer hospitalizations and reduced hospitalization costs.
Expert review of pharmacoeconomics & outcomes research.
2015 Jun; 15(3):545-50. doi:
10.1586/14737167.2015.995169. [PMID: 25495878] - Geoffrey A Block, Steven Fishbane, Mariano Rodriguez, Gerard Smits, Shay Shemesh, Pablo E Pergola, Myles Wolf, Glenn M Chertow. A 12-week, double-blind, placebo-controlled trial of ferric citrate for the treatment of iron deficiency anemia and reduction of serum phosphate in patients with CKD Stages 3-5.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
2015 May; 65(5):728-36. doi:
10.1053/j.ajkd.2014.10.014. [PMID: 25468387] - Chien-Te Lee, I-Wen Wu, Shou-Shan Chiang, Yu-Sen Peng, Kuo-Hsiung Shu, Ming-Ju Wu, Mai-Szu Wu. Effect of oral ferric citrate on serum phosphorus in hemodialysis patients: multicenter, randomized, double-blind, placebo-controlled study.
Journal of nephrology.
2015 Feb; 28(1):105-13. doi:
10.1007/s40620-014-0108-6. [PMID: 24840781] - Julia B Lewis, Mohammed Sika, Mark J Koury, Peale Chuang, Gerald Schulman, Mark T Smith, Frederick C Whittier, Douglas R Linfert, Claude M Galphin, Balaji P Athreya, A Kaldun Kaldun Nossuli, Ingrid J Chang, Samuel S Blumenthal, John Manley, Steven Zeig, Kotagal S Kant, Juan Jose Olivero, Tom Greene, Jamie P Dwyer. Ferric citrate controls phosphorus and delivers iron in patients on dialysis.
Journal of the American Society of Nephrology : JASN.
2015 Feb; 26(2):493-503. doi:
10.1681/asn.2014020212. [PMID: 25060056] - Akira Iguchi, Junichiro J Kazama, Suguru Yamamoto, Kazuhiro Yoshita, Yasuo Watanabe, Noriaki Iino, Ichiei Narita. Administration of Ferric Citrate Hydrate Decreases Circulating FGF23 Levels Independently of Serum Phosphate Levels in Hemodialysis Patients with Iron Deficiency.
Nephron.
2015; 131(3):161-6. doi:
10.1159/000440968. [PMID: 26551233] - Holger Schmid, Stephan R Lederer. Novel iron-containing phosphate binders for treatment of hyperphosphatemia.
Expert opinion on pharmacotherapy.
2015; 16(14):2179-91. doi:
10.1517/14656566.2015.1079622. [PMID: 26293683] - Takeshi Toyoda, Young-Man Cho, Yasuko Mizuta, Jun-ichi Akagi, Kumiko Ogawa. A 13-week subchronic toxicity study of ferric citrate in F344 rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2014 Dec; 74(?):68-75. doi:
10.1016/j.fct.2014.09.005. [PMID: 25257695] - Rina Shimizu, Nguyen Ngoc Lan, Tran Tien Tai, Yuka Adachi, Asako Kawazoe, Anfeng Mu, Shigeru Taketani. p53 directly regulates the transcription of the human frataxin gene and its lack of regulation in tumor cells decreases the utilization of mitochondrial iron.
Gene.
2014 Nov; 551(1):79-85. doi:
10.1016/j.gene.2014.08.043. [PMID: 25158131] - Marvin Sinsakul, Roger Rodby, Kausik Umanath, Robert Niecestro, Jamie P Dwyer. Ferric citrate spans mineral metabolism and anemia domains in ESRD: a review of efficacy and safety data.
Expert review of clinical pharmacology.
2014 Nov; 7(6):705-10. doi:
10.1586/17512433.2014.960848. [PMID: 25242077] - Cheryl A Thompson. Ferric citrate approved as phosphate binder for patients on dialysis.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.
2014 Nov; 71(21):1822. doi:
10.2146/news140072. [PMID: 25320124] - Akira Matsuo, Akio Iida, Minako Tanimoto, Mutsuyoshi Matsushita, Ken-ichi Miyamoto. The utility of the phosphate binder, ferric citrate hydrate (JTT-751), about phosphorus absorption-reducing effect in normal rats.
Renal failure.
2014 Sep; 36(8):1291-7. doi:
10.3109/0886022x.2014.930491. [PMID: 24975675] - Keitaro Yokoyama, Takashi Akiba, Masafumi Fukagawa, Masaaki Nakayama, Kenichi Sawada, Yuji Kumagai, Glenn M Chertow, Hideki Hirakata. Long-term safety and efficacy of a novel iron-containing phosphate binder, JTT-751, in patients receiving hemodialysis.
Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation.
2014 Jul; 24(4):261-7. doi:
10.1053/j.jrn.2014.03.006. [PMID: 24836401] - Keitaro Yokoyama, Takashi Akiba, Masafumi Fukagawa, Masaaki Nakayama, Kenichi Sawada, Yuji Kumagai, Glenn M Chertow, Hideki Hirakata. A randomized trial of JTT-751 versus sevelamer hydrochloride in patients on hemodialysis.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2014 May; 29(5):1053-60. doi:
10.1093/ndt/gft483. [PMID: 24376274] - Keitaro Yokoyama, Hideki Hirakata, Takashi Akiba, Masafumi Fukagawa, Masaaki Nakayama, Kenichi Sawada, Yuji Kumagai, Geoffrey A Block. Ferric citrate hydrate for the treatment of hyperphosphatemia in nondialysis-dependent CKD.
Clinical journal of the American Society of Nephrology : CJASN.
2014 Mar; 9(3):543-52. doi:
10.2215/cjn.05170513. [PMID: 24408120] - Keitaro Yokoyama, Takashi Akiba, Masafumi Fukagawa, Masaaki Nakayama, Hideki Hirakata. JTT-751 for treatment of patients with hyperphosphatemia on peritoneal dialysis.
Nephron. Clinical practice.
2014; 128(1-2):135-40. doi:
10.1159/000366482. [PMID: 25401266] - Jan Westerink, Jobien K Olijhoek, Arjen Koppen, Daniël R Faber, Eric Kalkhoven, Houshang Monajemi, B Sweder van Asbeck, Yolanda van der Graaf, Frank L J Visseren. The relation between body iron stores and adipose tissue function in patients with manifest vascular disease.
European journal of clinical investigation.
2013 Dec; 43(12):1240-9. doi:
10.1111/eci.12165. [PMID: 24245570] - Jamie P Dwyer, Mohammed Sika, Gerald Schulman, Ingrid J Chang, Michael Anger, Mark Smith, Mark Kaplan, Steven Zeig, Mark J Koury, Samuel S Blumenthal, Julia B Lewis. Dose-response and efficacy of ferric citrate to treat hyperphosphatemia in hemodialysis patients: a short-term randomized trial.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
2013 May; 61(5):759-66. doi:
10.1053/j.ajkd.2012.11.041. [PMID: 23369827] - Joao Arezes, Monica Costa, Ines Vieira, Vera Dias, Xiao L Kong, Rui Fernandes, Matthijn Vos, Anna Carlsson, Yuri Rikers, Graça Porto, Maria Rangel, Robert C Hider, Jorge P Pinto. Non-transferrin-bound iron (NTBI) uptake by T lymphocytes: evidence for the selective acquisition of oligomeric ferric citrate species.
PloS one.
2013; 8(11):e79870. doi:
10.1371/journal.pone.0079870. [PMID: 24278199] - Akio Iida, Yusuke Kemmochi, Kochi Kakimoto, Minako Tanimoto, Takayuki Mimura, Yuichi Shinozaki, Atsuhiro Uemura, Akira Matsuo, Mutsuyoshi Matsushita, Ken-ichi Miyamoto. Ferric citrate hydrate, a new phosphate binder, prevents the complications of secondary hyperparathyroidism and vascular calcification.
American journal of nephrology.
2013; 37(4):346-58. doi:
10.1159/000348805. [PMID: 23548309] - Kausik Umanath, Mohammed Sika, Robert Niecestro, Carolyn Connelly, Gerald Schulman, Mark J Koury, Julia B Lewis, Jamie P Dwyer. Rationale and study design of a three-period, 58-week trial of ferric citrate as a phosphate binder in patients with ESRD on dialysis.
Hemodialysis international. International Symposium on Home Hemodialysis.
2013 Jan; 17(1):67-74. doi:
10.1111/j.1542-4758.2012.00711.x. [PMID: 22702490] - Keitaro Yokoyama, Hideki Hirakata, Takashi Akiba, Kenichi Sawada, Yuji Kumagai. Effect of oral JTT-751 (ferric citrate) on hyperphosphatemia in hemodialysis patients: results of a randomized, double-blind, placebo-controlled trial.
American journal of nephrology.
2012; 36(5):478-87. doi:
10.1159/000344008. [PMID: 23147696] - Marvin Sinsakul, Mohammed Sika, Mark Koury, Warren Shapiro, Tom Greene, Jamie Dwyer, Mark Smith, Stephen Korbet, Julia Lewis. The safety and tolerability of ferric citrate as a phosphate binder in dialysis patients.
Nephron. Clinical practice.
2012; 121(1-2):c25-9. doi:
10.1159/000341922. [PMID: 23075669] - Piergiorgio Bolasco. [Effect of non-calcium-based phosphate binders on vascular calcifications in patients on hemodialysis: clinical experience and hypotheses].
Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia.
2011 Jul; 28(4):357. doi:
NULL. [PMID: 21809303] - Robert Sutak, Jan Slapeta, Mabel San Roman, Jean-Michel Camadro, Emmanuel Lesuisse. Nonreductive iron uptake mechanism in the marine alveolate Chromera velia.
Plant physiology.
2010 Oct; 154(2):991-1000. doi:
10.1104/pp.110.159947. [PMID: 20724644] - Patricia Evans, Reem Kayyali, Robert C Hider, John Eccleston, John B Porter. Mechanisms for the shuttling of plasma non-transferrin-bound iron (NTBI) onto deferoxamine by deferiprone.
Translational research : the journal of laboratory and clinical medicine.
2010 Aug; 156(2):55-67. doi:
10.1016/j.trsl.2010.05.002. [PMID: 20627190] - Andre M N Silva, XiaoLe Kong, Mark C Parkin, Richard Cammack, Robert C Hider. Iron(III) citrate speciation in aqueous solution.
Dalton transactions (Cambridge, England : 2003).
2009 Oct; ?(40):8616-25. doi:
10.1039/b910970f. [PMID: 19809738] - Pingzhang Gao, Yanhong Song, Hailing Li, Zhonghong Gao. Efficiency of methemoglobin, hemin and ferric citrate in catalyzing protein tyrosine nitration, protein oxidation and lipid peroxidation in a bovine serum albumin-liposome system: influence of pH.
Journal of inorganic biochemistry.
2009 May; 103(5):783-90. doi:
10.1016/j.jinorgbio.2009.01.020. [PMID: 19264360] - Robert W Evans, Roozina Rafique, Adel Zarea, Chiara Rapisarda, Richard Cammack, Patricia J Evans, John B Porter, Robert C Hider. Nature of non-transferrin-bound iron: studies on iron citrate complexes and thalassemic sera.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry.
2008 Jan; 13(1):57-74. doi:
10.1007/s00775-007-0297-8. [PMID: 17906879] - Jinyou Zhang, David Robinson, Peter Salmon. A novel function for selenium in biological system: selenite as a highly effective iron carrier for Chinese hamster ovary cell growth and monoclonal antibody production.
Biotechnology and bioengineering.
2006 Dec; 95(6):1188-97. doi:
10.1002/bit.21081. [PMID: 16937407] - J Bover, F Ortiz-Herbener, J Ballarín, E Andrés, P Barceló. [New therapy strategies in secondary hyperparathyroidism on dialysis (I): new concepts, new treatments].
Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia.
2005; 25 Suppl 2(?):100-8. doi:
NULL. [PMID: 16050412] - Anita C G Chua, John K Olynyk, Peter J Leedman, Debbie Trinder. Nontransferrin-bound iron uptake by hepatocytes is increased in the Hfe knockout mouse model of hereditary hemochromatosis.
Blood.
2004 Sep; 104(5):1519-25. doi:
10.1182/blood-2003-11-3872. [PMID: 15155457] - Carla Thomas, Phillip S Oates. Differences in the uptake of iron from Fe(II) ascorbate and Fe(III) citrate by IEC-6 cells and the involvement of ferroportin/IREG-1/MTP-1/SLC40A1.
Pflugers Archiv : European journal of physiology.
2004 Jul; 448(4):431-7. doi:
10.1007/s00424-004-1290-5. [PMID: 15114483]