U73122 (BioDeep_00001028444)
代谢物信息卡片
1-(6-((3-Methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione
化学式: C29H40N2O3 (464.30387700000006)
中文名称: U型73122
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC12CCC3C(C1CCC2NCCCCCCN4C(=O)C=CC4=O)CCC5=C3C=CC(=C5)OC
InChI: InChI=1S/C29H40N2O3/c1-29-16-15-23-22-10-8-21(34-2)19-20(22)7-9-24(23)25(29)11-12-26(29)30-17-5-3-4-6-18-31-27(32)13-14-28(31)33/h8,10,13-14,19,23-26,30H,3-7,9,11-12,15-18H2,1-2H3/t23-,24-,25+,26+,29+/m1/s1
描述信息
D006401 - Hematologic Agents > D010975 - Platelet Aggregation Inhibitors
D004791 - Enzyme Inhibitors > D010726 - Phosphodiesterase Inhibitors
U-73122 is a phospholipase C (PLC) and 5-LO (5-lipoxygenase) inhibitor with an IC50of 1-2.1 μM for PLC.
同义名列表
数据库引用编号
5 个数据库交叉引用编号
- ChEBI: CHEBI:90690
- PubChem: 104794
- ChEMBL: CHEMBL1256678
- CAS: 112648-68-7
- medchemexpress: HY-13419
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Hao Chai, Fangfang Xu, Jixia Wang, Yuxin Zhang, Xiaomin Xie, Han Zhou, Yanfang Liu, Xinmiao Liang, Aoxue Wang. Profiling CCR3 target pathways for discovering novel antagonists from natural products using label-free cell phenotypic assays.
Chemico-biological interactions.
2023 Nov; 385(?):110732. doi:
10.1016/j.cbi.2023.110732. [PMID: 37788752] - Rohit Arora, Kenny M Van Theemsche, Samuel Van Remoortel, Dirk J Snyders, Alain J Labro, Jean-Pierre Timmermans. Constitutive, Basal, and β-Alanine-Mediated Activation of the Human Mas-Related G Protein-Coupled Receptor D Induces Release of the Inflammatory Cytokine IL-6 and Is Dependent on NF-κB Signaling.
International journal of molecular sciences.
2021 Dec; 22(24):. doi:
10.3390/ijms222413254. [PMID: 34948051] - Julliana F Sant'Anna, Vanessa S Baldez, Natalie A Razuck-Garrão, Thiago Lemos, Bruno L Diaz, Marcelo Einicker-Lamas. Lysophosphatidic acid (LPA) as a modulator of plasma membrane Ca2+-ATPase from basolateral membranes of kidney proximal tubules.
Journal of physiology and biochemistry.
2021 May; 77(2):321-329. doi:
10.1007/s13105-021-00800-5. [PMID: 33704695] - Xiang Li, Xun Cui, Shuai Zhou, Da-Lin Xing, Hu-Ri Piao, Qing-Gao Zhang, Yu-Qing Zhao, Li-Ping Liu. The novel ginsenoside AD2 prevents angiotensin II-induced connexin 40 and connexin 43 dysregulation by activating AMP kinase signaling in perfused beating rat atria.
Chemico-biological interactions.
2021 Apr; 339(?):109430. doi:
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Cancer research.
2020 12; 80(24):5491-5501. doi:
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European journal of pharmacology.
2019 Jul; 854(?):372-379. doi:
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Nature communications.
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American journal of physiology. Endocrinology and metabolism.
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PloS one.
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2014 Dec; 204(4):873-81. doi:
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2014 Jan; 108(?):9-22. doi:
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The Journal of biological chemistry.
2013 Nov; 288(47):33585-33597. doi:
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2013 Aug; 305(3):C276-89. doi:
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The Journal of endocrinology.
2013 Jun; 217(3):317-26. doi:
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2013 May; 1833(5):1165-72. doi:
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The Journal of nutrition.
2013 May; 143(5):584-90. doi:
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Molecules and cells.
2013 Feb; 35(2):142-50. doi:
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Endocrinology.
2013 Feb; 154(2):865-75. doi:
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Journal of receptor and signal transduction research.
2012 Dec; 32(6):335-41. doi:
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Biochemical and biophysical research communications.
2012 Oct; 427(3):600-5. doi:
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Basic & clinical pharmacology & toxicology.
2012 Oct; 111(4):224-31. doi:
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European journal of pharmacology.
2012 Sep; 691(1-3):93-102. doi:
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Steroids.
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Clinical and experimental nephrology.
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Plant & cell physiology.
2012 Jan; 53(1):183-92. doi:
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The Biochemical journal.
2011 Dec; 440(3):355-65. doi:
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2011 Oct; 14(11):1439-46. doi:
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The Journal of general physiology.
2011 Jan; 137(1):111-32. doi:
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Planta.
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Journal of dental research.
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Vascular pharmacology.
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Journal of plant physiology.
2010 Mar; 167(5):411-5. doi:
10.1016/j.jplph.2009.10.003. [PMID: 19889473] - Giovanna Valenti, Annalisa Mira, Lisa Mastrofrancesco, Domenica Rita Lasorsa, Marianna Ranieri, Maria Svelto. Differential modulation of intracellular Ca2+ responses associated with calcium-sensing receptor activation in renal collecting duct cells.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2010; 26(6):901-12. doi:
10.1159/000323999. [PMID: 21220921] - Scott Crousillac, Jeremy Colonna, Emily McMains, Jill Sayes Dewey, Evanna Gleason. Sphingosine-1-phosphate elicits receptor-dependent calcium signaling in retinal amacrine cells.
Journal of neurophysiology.
2009 Dec; 102(6):3295-309. doi:
10.1152/jn.00119.2009. [PMID: 19776367] - Kumiko Yamaoka, Akiko Yano, Kenji Kuroiwa, Kazushi Morimoto, Tomoaki Inazumi, Noriyuki Hatae, Hiroyuki Tabata, Eri Segi-Nishida, Satoshi Tanaka, Atsushi Ichikawa, Yukihiko Sugimoto. Prostaglandin EP3 receptor superactivates adenylyl cyclase via the Gq/PLC/Ca2+ pathway in a lipid raft-dependent manner.
Biochemical and biophysical research communications.
2009 Nov; 389(4):678-82. doi:
10.1016/j.bbrc.2009.09.064. [PMID: 19769944] - Tom Schilling, Claudia Eder. Non-selective cation channel activity is required for lysophosphatidylcholine-induced monocyte migration.
Journal of cellular physiology.
2009 Nov; 221(2):325-34. doi:
10.1002/jcp.21857. [PMID: 19562685] - Ching-Hsein Chen, Shu-Jem Su, Kee-Lung Chang, Mei-Wen Huang, Soong-Yu Kuo. The garlic ingredient diallyl sulfide induces Ca(2+) mobilization in Madin-Darby canine kidney cells.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2009 Sep; 47(9):2344-50. doi:
10.1016/j.fct.2009.06.028. [PMID: 19555733] - Mariana G Todorova, Esther Fuentes, Bernat Soria, Angel Nadal, Ivan Quesada. Lysophosphatidic acid induces Ca2+ mobilization and c-Myc expression in mouse embryonic stem cells via the phospholipase C pathway.
Cellular signalling.
2009 Apr; 21(4):523-8. doi:
10.1016/j.cellsig.2008.12.005. [PMID: 19136060] - Shweta Mittar, Clare Ulyatt, Gareth J Howell, Alexander F Bruns, Ian Zachary, John H Walker, Sreenivasan Ponnambalam. VEGFR1 receptor tyrosine kinase localization to the Golgi apparatus is calcium-dependent.
Experimental cell research.
2009 Mar; 315(5):877-89. doi:
10.1016/j.yexcr.2008.12.020. [PMID: 19162007] - Randa Hilal-Dandan, Huaping He, Jody L Martin, Laurence L Brunton, Wolfgang H Dillmann. Endothelin downregulates SERCA2 gene and protein expression in adult rat ventricular myocytes: regulation by pertussis toxin-sensitive Gi protein and cAMP.
American journal of physiology. Heart and circulatory physiology.
2009 Mar; 296(3):H728-34. doi:
10.1152/ajpheart.00584.2008. [PMID: 19151257] - Alvaro Yogi, Glaucia E Callera, Rita Tostes, Rhian M Touyz. Bradykinin regulates calpain and proinflammatory signaling through TRPM7-sensitive pathways in vascular smooth muscle cells.
American journal of physiology. Regulatory, integrative and comparative physiology.
2009 Feb; 296(2):R201-7. doi:
10.1152/ajpregu.90602.2008. [PMID: 18799634] - Lin-lin Yu, Jin-hu Zhang, Ya-ping He, Ping Huang, Li-min Yue. Fast action of estrogen on intracellular calcium in dormant mouse blastocyst and its possible mechanism.
Fertility and sterility.
2009 Feb; 91(2):611-5. doi:
10.1016/j.fertnstert.2007.11.072. [PMID: 18295211] - Fang-Li Zhao, Scott Herness. Resynthesis of phosphatidylinositol 4,5-bisphosphate mediates adaptation of the caffeine response in rat taste receptor cells.
The Journal of physiology.
2009 Jan; 587(2):363-77. doi:
10.1113/jphysiol.2008.165167. [PMID: 19047199] - Brenda A Finney, Pierre M del Moral, William J Wilkinson, Sebastien Cayzac, Martin Cole, David Warburton, Paul J Kemp, Daniela Riccardi. Regulation of mouse lung development by the extracellular calcium-sensing receptor, CaR.
The Journal of physiology.
2008 Dec; 586(24):6007-19. doi:
10.1113/jphysiol.2008.161687. [PMID: 18955379] - Ana Gomis, Sergio Soriano, Carlos Belmonte, Félix Viana. Hypoosmotic- and pressure-induced membrane stretch activate TRPC5 channels.
The Journal of physiology.
2008 Dec; 586(23):5633-49. doi:
10.1113/jphysiol.2008.161257. [PMID: 18832422] - Shawn Hopewell, Nihar R Pandey, Ayesha Misquith, Erin Twomey, Daniel L Sparks. Phosphatidylinositol acts through mitogen-activated protein kinase to stimulate hepatic apolipoprotein A-I secretion.
Metabolism: clinical and experimental.
2008 Dec; 57(12):1677-84. doi:
10.1016/j.metabol.2008.07.023. [PMID: 19013290] - Beatriz Fioravanti, Milena De Felice, Cheryl L Stucky, Karen A Medler, Miaw-Chyi Luo, Luis R Gardell, Mohab Ibrahim, T Phil Malan, Henry I Yamamura, Michael H Ossipov, Tamara King, Josephine Lai, Frank Porreca, Todd W Vanderah. Constitutive activity at the cannabinoid CB1 receptor is required for behavioral response to noxious chemical stimulation of TRPV1: antinociceptive actions of CB1 inverse agonists.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2008 Nov; 28(45):11593-602. doi:
10.1523/jneurosci.3322-08.2008. [PMID: 18987195] - Methee Chayakulkeeree, Tania C Sorrell, A Rosemary Siafakas, Christabel F Wilson, Namfon Pantarat, Kimberly J Gerik, Ross Boadle, Julianne T Djordjevic. Role and mechanism of phosphatidylinositol-specific phospholipase C in survival and virulence of Cryptococcus neoformans.
Molecular microbiology.
2008 Aug; 69(4):809-26. doi:
10.1111/j.1365-2958.2008.06310.x. [PMID: 18532984] - Boyi Liu, Huiling Liang, Li Liu, Hailin Zhang. Phosphatidylinositol 4,5-bisphosphate hydrolysis mediates histamine-induced KCNQ/M current inhibition.
American journal of physiology. Cell physiology.
2008 Jul; 295(1):C81-91. doi:
10.1152/ajpcell.00028.2008. [PMID: 18448631] - Vikas Kumar, Yuh-Jiin I Jong, Karen L O'Malley. Activated nuclear metabotropic glutamate receptor mGlu5 couples to nuclear Gq/11 proteins to generate inositol 1,4,5-trisphosphate-mediated nuclear Ca2+ release.
The Journal of biological chemistry.
2008 May; 283(20):14072-83. doi:
10.1074/jbc.m708551200. [PMID: 18337251] - Irina Vetter, Bruce D Wyse, Sarah J Roberts-Thomson, Gregory R Monteith, Peter J Cabot. Mechanisms involved in potentiation of transient receptor potential vanilloid 1 responses by ethanol.
European journal of pain (London, England).
2008 May; 12(4):441-54. doi:
10.1016/j.ejpain.2007.07.001. [PMID: 17826200] - Edwin K Jackson, Delbert G Gillespie, Chongxue Zhu, Jin Ren, Lefteris C Zacharia, Zaichuan Mi. Alpha2-adrenoceptors enhance angiotensin II-induced renal vasoconstriction: role for NADPH oxidase and RhoA.
Hypertension (Dallas, Tex. : 1979).
2008 Mar; 51(3):719-26. doi:
10.1161/hypertensionaha.107.096297. [PMID: 18250367] - Moon Ho Park, Dae Hie Lee. Endothelin 1 protects HN33 cells from serum deprivation-induced neuronal apoptosis through Ca(2+)-PKCalpha-ERK pathway.
Experimental & molecular medicine.
2008 Feb; 40(1):92-7. doi:
10.3858/emm.2008.40.1.92. [PMID: 18305402] - Huda Ismail Abdullah, Paulina L Pedraza, John C McGiff, Nicholas R Ferreri. CaR activation increases TNF production by mTAL cells via a Gi-dependent mechanism.
American journal of physiology. Renal physiology.
2008 Feb; 294(2):F345-54. doi:
10.1152/ajprenal.00509.2006. [PMID: 18032544] - George Komis, Basil Galatis, Hartmut Quader, Dia Galanopoulou, Panagiotis Apostolakos. Phospholipase C signaling involvement in macrotubule assembly and activation of the mechanism regulating protoplast volume in plasmolyzed root cells of Triticum turgidum.
The New phytologist.
2008; 178(2):267-282. doi:
10.1111/j.1469-8137.2007.02363.x. [PMID: 18221245] - I V Shemarova, G V Selivanova, T D Vlasova. [Changes in the DNA content in EGF-stimulated ciliate Tetrahymena pyriformis under effect of caffeine, KCl, and inhibitors of PLC and PKC].
Tsitologiia.
2008; 50(11):999-1004. doi:
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Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2008; 22(5-6):413-22. doi:
10.1159/000185484. [PMID: 19088423] - Wessel van Leeuwen, Joop E M Vermeer, Theodorus W J Gadella, Teun Munnik. Visualization of phosphatidylinositol 4,5-bisphosphate in the plasma membrane of suspension-cultured tobacco BY-2 cells and whole Arabidopsis seedlings.
The Plant journal : for cell and molecular biology.
2007 Dec; 52(6):1014-26. doi:
10.1111/j.1365-313x.2007.03292.x. [PMID: 17908156] - Takahiro Shimizu, Naoko Yamaguchi, Shoshiro Okada, Lianyi Lu, Tsuyoshi Sasaki, Kunihiko Yokotani. Roles of brain phosphatidylinositol-specific phospholipase C and diacylglycerol lipase in centrally administered histamine-induced adrenomedullary outflow in rats.
European journal of pharmacology.
2007 Oct; 571(2-3):138-44. doi:
10.1016/j.ejphar.2007.05.061. [PMID: 17628524] - Alberto M Díaz Añel. Phospholipase C beta3 is a key component in the Gbetagamma/PKCeta/PKD-mediated regulation of trans-Golgi network to plasma membrane transport.
The Biochemical journal.
2007 Aug; 406(1):157-65. doi:
10.1042/bj20070359. [PMID: 17492941] - Ana M Laxalt, Nicolás Raho, Arjen Ten Have, Lorenzo Lamattina. Nitric oxide is critical for inducing phosphatidic acid accumulation in xylanase-elicited tomato cells.
The Journal of biological chemistry.
2007 Jul; 282(29):21160-8. doi:
10.1074/jbc.m701212200. [PMID: 17491015] - Hideyuki Takahashi, Hideo Namiki. Mechanism of membrane redistribution of protein kinase C by its ATP-competitive inhibitors.
The Biochemical journal.
2007 Jul; 405(2):331-40. doi:
10.1042/bj20070299. [PMID: 17373912] - Tom Litjens, Than Nguyen, Joel Castro, Edoardo C Aromataris, Lynette Jones, Greg J Barritt, Grigori Y Rychkov. Phospholipase C-gamma1 is required for the activation of store-operated Ca2+ channels in liver cells.
The Biochemical journal.
2007 Jul; 405(2):269-76. doi:
10.1042/bj20061762. [PMID: 17432954] - Salam Ibrahim, Catherine Calzada, Valérie Pruneta-Deloche, Michel Lagarde, Gabriel Ponsin. The transfer of VLDL-associated phospholipids to activated platelets depends upon cytosolic phospholipase A2 activity.
Journal of lipid research.
2007 Jul; 48(7):1533-8. doi:
10.1194/jlr.m600480-jlr200. [PMID: 17456899] - Nicola E Wilsher, Will J Court, Ruth Ruddle, Yvette M Newbatt, Wynne Aherne, Peter W Sheldrake, Neil P Jones, Matilda Katan, Suzanne A Eccles, Florence I Raynaud. The phosphoinositide-specific phospholipase C inhibitor U73122 (1-(6-((17beta-3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione) spontaneously forms conjugates with common components of cell culture medium.
Drug metabolism and disposition: the biological fate of chemicals.
2007 Jul; 35(7):1017-22. doi:
10.1124/dmd.106.014498. [PMID: 17403917] - Nidhi Kapur, Kathrin Banach. Inositol-1,4,5-trisphosphate-mediated spontaneous activity in mouse embryonic stem cell-derived cardiomyocytes.
The Journal of physiology.
2007 Jun; 581(Pt 3):1113-27. doi:
10.1113/jphysiol.2006.125955. [PMID: 17379641] - Rutilio A Fratti, Kevin M Collins, Christopher M Hickey, William Wickner. Stringent 3Q.1R composition of the SNARE 0-layer can be bypassed for fusion by compensatory SNARE mutation or by lipid bilayer modification.
The Journal of biological chemistry.
2007 May; 282(20):14861-7. doi:
10.1074/jbc.m700971200. [PMID: 17400548] - Jing-Ji Zhang, Guang-Zhe Huang, Mimi Halpern. Firing properties of accessory olfactory bulb mitral/tufted cells in response to urine delivered to the vomeronasal organ of gray short-tailed opossums.
Chemical senses.
2007 May; 32(4):355-60. doi:
10.1093/chemse/bjm005. [PMID: 17325343] - Yaohong Wang, Alok Tomar, Sudeep P George, Seema Khurana. Obligatory role for phospholipase C-gamma(1) in villin-induced epithelial cell migration.
American journal of physiology. Cell physiology.
2007 May; 292(5):C1775-86. doi:
10.1152/ajpcell.00420.2006. [PMID: 17229814] - Elodie Parre, Mohamed Ali Ghars, Anne-Sophie Leprince, Laurent Thiery, Delphine Lefebvre, Marianne Bordenave, Luc Richard, Christian Mazars, Chedly Abdelly, Arnould Savouré. Calcium signaling via phospholipase C is essential for proline accumulation upon ionic but not nonionic hyperosmotic stresses in Arabidopsis.
Plant physiology.
2007 May; 144(1):503-12. doi:
10.1104/pp.106.095281. [PMID: 17369432]