Oxotremorine M (BioDeep_00001028442)
代谢物信息卡片
Oxotremorine M
化学式: C11H19N2O+ (195.14973039999998)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C[N+](C)(C)CC#CCN1CCCC1=O
InChI: InChI=1S/C11H19N2O/c1-13(2,3)10-5-4-8-12-9-6-7-11(12)14/h6-10H2,1-3H3/q+1
描述信息
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D018679 - Cholinergic Agonists
同义名列表
1 个代谢物同义名
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jian-Fang Li, Xiao-Yu Zhang, Xue Bai, Hong-Ai Su, Ya-Lan Liu, Yong-Yue Lu, Yi-Xiang Qi. Identification of putative muscarinic acetylcholine receptor genes in Bactrocera dorsalis and functional analysis of Bdor-mAChR-B.
Insect biochemistry and molecular biology.
2021 12; 139(?):103657. doi:
10.1016/j.ibmb.2021.103657. [PMID: 34582990] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Liwang Liu, Joseph V Bonventre, Ann R Rittenhouse. cPLA2α-/- sympathetic neurons exhibit increased membrane excitability and loss of N-Type Ca2+ current inhibition by M1 muscarinic receptor signaling.
PloS one.
2018; 13(12):e0201322. doi:
10.1371/journal.pone.0201322. [PMID: 30557348] - Daniel J Foster, Jermaine M Wilson, Daniel H Remke, M Suhaib Mahmood, M Jashim Uddin, Jürgen Wess, Sachin Patel, Lawrence J Marnett, Colleen M Niswender, Carrie K Jones, Zixiu Xiang, Craig W Lindsley, Jerri M Rook, P Jeffrey Conn. Antipsychotic-like Effects of M4 Positive Allosteric Modulators Are Mediated by CB2 Receptor-Dependent Inhibition of Dopamine Release.
Neuron.
2016 Sep; 91(6):1244-1252. doi:
10.1016/j.neuron.2016.08.017. [PMID: 27618677] - Daniel J Foster, Anne M Heacock, Stephen K Fisher. Muscarinic receptor stimulation of D-aspartate uptake into human SH-SY5Y neuroblastoma cells is attenuated by hypoosmolarity.
The Journal of pharmacology and experimental therapeutics.
2010 Apr; 333(1):297-309. doi:
10.1124/jpet.109.164277. [PMID: 20080957] - Jun Liu, Imtiaz Rasul, Yuning Sun, Guisheng Wu, Longxuan Li, Richard T Premont, William Z Suo. GRK5 deficiency leads to reduced hippocampal acetylcholine level via impaired presynaptic M2/M4 autoreceptor desensitization.
The Journal of biological chemistry.
2009 Jul; 284(29):19564-71. doi:
10.1074/jbc.m109.005959. [PMID: 19478075] - Liwang Liu, John F Heneghan, Gregory J Michael, Lee F Stanish, Michaela Egertová, Ann R Rittenhouse. L- and N-current but not M-current inhibition by M1 muscarinic receptors requires DAG lipase activity.
Journal of cellular physiology.
2008 Jul; 216(1):91-100. doi:
10.1002/jcp.21378. [PMID: 18247369] - Chang-Xi Bai, Aurélie Giamarchi, Lise Rodat-Despoix, Françoise Padilla, Tamyra Downs, Leonidas Tsiokas, Patrick Delmas. Formation of a new receptor-operated channel by heteromeric assembly of TRPP2 and TRPC1 subunits.
EMBO reports.
2008 May; 9(5):472-9. doi:
10.1038/embor.2008.29. [PMID: 18323855] - Byung-Chang Suh, Takanari Inoue, Tobias Meyer, Bertil Hille. Rapid chemically induced changes of PtdIns(4,5)P2 gate KCNQ ion channels.
Science (New York, N.Y.).
2006 Dec; 314(5804):1454-7. doi:
10.1126/science.1131163. [PMID: 16990515] - Lisa F Horowitz, Wiebke Hirdes, Byung-Chang Suh, Donald W Hilgemann, Ken Mackie, Bertil Hille. Phospholipase C in living cells: activation, inhibition, Ca2+ requirement, and regulation of M current.
The Journal of general physiology.
2005 Sep; 126(3):243-62. doi:
10.1085/jgp.200509309. [PMID: 16129772] - Alokesh Duttaroy, Charles L Zimliki, Dinesh Gautam, Yinghong Cui, David Mears, Jürgen Wess. Muscarinic stimulation of pancreatic insulin and glucagon release is abolished in m3 muscarinic acetylcholine receptor-deficient mice.
Diabetes.
2004 Jul; 53(7):1714-20. doi:
10.2337/diabetes.53.7.1714. [PMID: 15220195] - Juan Guo, Geoffery G Schofield. Activation of muscarinic m5 receptors inhibits recombinant KCNQ2/KCNQ3 K+ channels expressed in HEK293T cells.
European journal of pharmacology.
2003 Feb; 462(1-3):25-32. doi:
10.1016/s0014-2999(03)01323-2. [PMID: 12591092] - J W Daly, T H Gupta, W L Padgett, X F Pei. 6beta-Acyloxy(nor)tropanes: affinities for antagonist/agonist binding sites on transfected and native muscarinic receptors.
Journal of medicinal chemistry.
2000 Jun; 43(13):2514-22. doi:
10.1021/jm9904001. [PMID: 10891110] - J Zhou, M S Shapiro, B Hille. Speed of Ca2+ channel modulation by neurotransmitters in rat sympathetic neurons.
Journal of neurophysiology.
1997 Apr; 77(4):2040-8. doi:
10.1152/jn.1997.77.4.2040. [PMID: 9114253] - S D Sorensen, E L McEwen, D A Linseman, S K Fisher. Agonist-induced endocytosis of muscarinic cholinergic receptors: relationship to stimulated phosphoinositide turnover.
Journal of neurochemistry.
1997 Apr; 68(4):1473-83. doi:
10.1046/j.1471-4159.1997.68041473.x. [PMID: 9084417] - T J Grudt, M M Usowicz, G Henderson. Ca2+ entry following store depletion in SH-SY5Y neuroblastoma cells.
Brain research. Molecular brain research.
1996 Feb; 36(1):93-100. doi:
10.1016/0169-328x(95)00248-q. [PMID: 9011769] - A C Boschero, M Szpak-Glasman, E M Carneiro, S Bordin, I Paul, E Rojas, I Atwater. Oxotremorine-m potentiation of glucose-induced insulin release from rat islets involves M3 muscarinic receptors.
The American journal of physiology.
1995 Feb; 268(2 Pt 1):E336-42. doi:
10.1152/ajpendo.1995.268.2.e336. [PMID: 7864111] - A C Boschero, S C Crepaldi, E M Carneiro, E Delattre, I Atwater. Prolactin induces maturation of glucose sensing mechanisms in cultured neonatal rat islets.
Endocrinology.
1993 Aug; 133(2):515-20. doi:
10.1210/endo.133.2.8344197. [PMID: 8344197] - S K Fisher, E L McEwen, S C Lovell, R E Landon. Cyclic AMP potentiates receptor-stimulated phosphoinositide hydrolysis in human neuroepithelioma cells.
Molecular pharmacology.
1992 Aug; 42(2):340-6. doi:
". [PMID: 1355263] - C Lee, S K Fisher, B W Agranoff, A K Hajra. Quantitative analysis of molecular species of diacylglycerol and phosphatidate formed upon muscarinic receptor activation of human SK-N-SH neuroblastoma cells.
The Journal of biological chemistry.
1991 Dec; 266(34):22837-46. doi:
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Journal of neurochemistry.
1984 Oct; 43(4):1171-9. doi:
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