Diphenyleneiodonium chloride (BioDeep_00001028423)
代谢物信息卡片
Diphenyleneiodonium chloride
化学式: C12H8ClI (313.9359268)
中文名称: 氯化二亚苯基碘鎓
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C12=CC=CC=C1C3=CC=CC=C3[I+]2.[Cl-]
InChI: /p-1
描述信息
D007004 - Hypoglycemic Agents
D004791 - Enzyme Inhibitors
Diphenyleneiodonium chloride is a NADPH oxidase (NOX) inhibitor and also functions as a TRPA1 activator with an EC50 of 1 to 3 μM. Diphenyleneiodonium chloride selectively inhibits intracellular reactive oxygen species.
同义名列表
2 个代谢物同义名
数据库引用编号
5 个数据库交叉引用编号
- ChEBI: CHEBI:77967
- PubChem: 2733504
- ChEMBL: CHEMBL397686
- CAS: 4673-26-1
- medchemexpress: HY-100965
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jian Xu, Dong Zhang, Yibo Ma, Hui Du, Yi Wang, Wenping Luo, Ruxing Wang, Fu Yi. ROS in diabetic atria regulate SK2 degradation by Atrogin-1 through the NF-κB signaling pathway.
The Journal of biological chemistry.
2024 Mar; 300(3):105735. doi:
10.1016/j.jbc.2024.105735. [PMID: 38336298] - Sadia Monzur, Ghmkin Hassan, Said M Afify, Kazuki Kumon, Hager Mansour, Hend M Nawara, Mona Sheta, Hagar A Abu Quora, Maram H Zahra, Yanning Xu, Xiaoyin Fu, Akimasa Seno, Per Wikström, Ferenc L M Szekeres, Masaharu Seno. Diphenyleneiodonium efficiently inhibits the characteristics of a cancer stem cell model derived from induced pluripotent stem cells.
Cell biochemistry and function.
2022 Apr; 40(3):310-320. doi:
10.1002/cbf.3696. [PMID: 35285948] - Guzel Sharipova, Ruslan Ivanov, Dmitriy Veselov, Guzel Akhiyarova, Maria Shishova, Tatyana Nuzhnaya, Guzel Kudoyarova. Involvement of Reactive Oxygen Species in ABA-Induced Increase in Hydraulic Conductivity and Aquaporin Abundance.
International journal of molecular sciences.
2021 Aug; 22(17):. doi:
10.3390/ijms22179144. [PMID: 34502052] - Yun Chen, Yuanhua Chen, Yajun Zhang, Dongping Zhang, Guoming Li, Jiali Wei, Xia Hua, Bing Lv, Lijun Liu. Heterotrimeric G protein γ subunit DEP1 is involved in hydrogen peroxide signaling and promotes aerenchyma formation in rice roots.
Plant signaling & behavior.
2021 05; 16(5):1889251. doi:
10.1080/15592324.2021.1889251. [PMID: 33632064] - Yanfeng Sun, Weihong Liang, Hui Cheng, Huan Wang, Dong Lv, Wei Wang, Modan Liang, Chen Miao. NADPH Oxidase-derived ROS promote mitochondrial alkalization under salt stress in Arabidopsis root cells.
Plant signaling & behavior.
2021 03; 16(3):1856546. doi:
10.1080/15592324.2020.1856546. [PMID: 33315520] - Zhuqing Wang, Duoyan Rong, Dixing Chen, Yang Xiao, Renyi Liu, Shuang Wu, Chizuko Yamamuro. Salicylic acid promotes quiescent center cell division through ROS accumulation and down-regulation of PLT1, PLT2, and WOX5.
Journal of integrative plant biology.
2021 Mar; 63(3):583-596. doi:
10.1111/jipb.13020. [PMID: 33017089] - Xufang Ren, Mengfang Wang, Yongshun Wang, Aixia Huang. Superoxide anion generation response to wound in Arabidopsis hypocotyl cutting.
Plant signaling & behavior.
2021 02; 16(2):1848086. doi:
10.1080/15592324.2020.1848086. [PMID: 33210579] - Zahra Souri, Naser Karimi, Parvaiz Ahmad. The effect of NADPH oxidase inhibitor diphenyleneiodonium (DPI) and glutathione (GSH) on Isatis cappadocica, under Arsenic (As) toxicity.
International journal of phytoremediation.
2021; 23(9):945-957. doi:
10.1080/15226514.2020.1870435. [PMID: 33472408] - Yafei Chen, Sarmina Dangol, Juan Wang, Nam-Soo Jwa. Focal Accumulation of ROS Can Block Pyricularia oryzae Effector BAS4-Expression and Prevent Infection in Rice.
International journal of molecular sciences.
2020 Aug; 21(17):. doi:
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Autophagy.
2020 07; 16(7):1314-1331. doi:
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Neuroscience bulletin.
2020 May; 36(5):463-474. doi:
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Plant cell reports.
2020 May; 39(5):567-575. doi:
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Plant cell reports.
2020 Jan; 39(1):63-73. doi:
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Journal of experimental botany.
2019 10; 70(20):5879-5893. doi:
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ImmunoHorizons.
2019 10; 3(10):488-497. doi:
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Haematologica.
2019 09; 104(9):e393-e397. doi:
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Plant science : an international journal of experimental plant biology.
2019 Mar; 280(?):305-313. doi:
10.1016/j.plantsci.2018.12.011. [PMID: 30824008] - Amar Yeware, Suwarna Gample, Sonia Agrawal, Dhiman Sarkar. Using diphenyleneiodonium to induce a viable but non-culturable phenotype in Mycobacterium tuberculosis and its metabolomics analysis.
PloS one.
2019; 14(8):e0220628. doi:
10.1371/journal.pone.0220628. [PMID: 31369628] - Nahla Issa, Gabriel Lachance, Kerstin Bellmann, Mathieu Laplante, Krisztian Stadler, André Marette. Cytokines promote lipolysis in 3T3-L1 adipocytes through induction of NADPH oxidase 3 expression and superoxide production.
Journal of lipid research.
2018 12; 59(12):2321-2328. doi:
10.1194/jlr.m086504. [PMID: 30317185] - Liqian Zhu, Xiaotian Fu, Chen Yuan, Xinyi Jiang, Gaiping Zhang. Induction of Oxidative DNA Damage in Bovine Herpesvirus 1 Infected Bovine Kidney Cells (MDBK Cells) and Human Tumor Cells (A549 Cells and U2OS Cells).
Viruses.
2018 07; 10(8):. doi:
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Plant science : an international journal of experimental plant biology.
2018 Apr; 269(?):1-11. doi:
10.1016/j.plantsci.2018.01.002. [PMID: 29606206] - Q M Chen, Y Yu, C M Lin, N Cui, J Y Zhao, T F Song, H Y Fan. Glucohexaose-induced protein phosphatase 2C regulates cell redox status of cucumber seedling.
Journal of biosciences.
2018 Mar; 43(1):117-126. doi:
10.1007/s12038-018-9738-5. [PMID: 29485120] - Pinke Patel, Guruprasad Kadur Narayanaswamy, Sunita Kataria, Lokesh Baghel. Involvement of nitric oxide in enhanced germination and seedling growth of magnetoprimed maize seeds.
Plant signaling & behavior.
2017 12; 12(12):e1293217. doi:
10.1080/15592324.2017.1293217. [PMID: 28277969] - Soyong Jang, Taddesse Yayeh, Yea-Hyun Leem, Eun-Mi Park, Yoshihisa Ito, Seikwan Oh. Concanavalin A Induces Cortical Neuron Apoptosis by Causing ROS Accumulation and Tyrosine Kinase Activation.
Neurochemical research.
2017 Dec; 42(12):3504-3514. doi:
10.1007/s11064-017-2398-2. [PMID: 29019035] - Alok Kumar Singh, Ritesh Thakare, Pratiksha Karaulia, Swetarka Das, Isha Soni, Manitosh Pandey, Amit Kumar Pandey, Sidharth Chopra, Arunava Dasgupta. Biological evaluation of diphenyleneiodonium chloride (DPIC) as a potential drug candidate for treatment of non-tuberculous mycobacterial infections.
The Journal of antimicrobial chemotherapy.
2017 Nov; 72(11):3117-3121. doi:
10.1093/jac/dkx277. [PMID: 28961864] - Zhong-Hua Ji, Zhong-Jie Liu, Zi-Ting Liu, Wei Zhao, Brian A Williams, Hong-Fei Zhang, Le Li, Shi-Yuan Xu. Diphenyleneiodonium Mitigates Bupivacaine-Induced Sciatic Nerve Damage in a Diabetic Neuropathy Rat Model by Attenuating Oxidative Stress.
Anesthesia and analgesia.
2017 08; 125(2):653-661. doi:
10.1213/ane.0000000000002186. [PMID: 28682956] - Do-Hee Kim, Ji Eun Park, In Gyeong Chae, Geumi Park, Sooyeun Lee, Kyung-Soo Chun. Isoliquiritigenin inhibits the proliferation of human renal carcinoma Caki cells through the ROS-mediated regulation of the Jak2/STAT3 pathway.
Oncology reports.
2017 Jul; 38(1):575-583. doi:
10.3892/or.2017.5677. [PMID: 28560439] - Min Yao, Feng Gao, Xiaomeng Wang, Yonghong Shi, Shuxia Liu, Huijun Duan. Nox4 is involved in high glucose-induced apoptosis in renal tubular epithelial cells via Notch pathway.
Molecular medicine reports.
2017 Jun; 15(6):4319-4325. doi:
10.3892/mmr.2017.6516. [PMID: 28487945] - Irina V Fedoseeva, Darya V Pyatrikas, Alexei V Stepanov, Anna V Fedyaeva, Nina N Varakina, Tatyana M Rusaleva, Gennadii B Borovskii, Eugene G Rikhvanov. The role of flavin-containing enzymes in mitochondrial membrane hyperpolarization and ROS production in respiring Saccharomyces cerevisiae cells under heat-shock conditions.
Scientific reports.
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Physiologia plantarum.
2017 Feb; 159(2):228-243. doi:
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International journal of molecular sciences.
2017 Jan; 18(1):. doi:
10.3390/ijms18010110. [PMID: 28098759] - Shutong Yao, Hua Tian, Li Zhao, Jinguo Li, Libo Yang, Feng Yue, Yanyan Li, Peng Jiao, Nana Yang, Yiwei Wang, Xiangjian Zhang, Shucun Qin. Oxidized high density lipoprotein induces macrophage apoptosis via toll-like receptor 4-dependent CHOP pathway.
Journal of lipid research.
2017 01; 58(1):164-177. doi:
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Plant & cell physiology.
2017 01; 58(1):71-85. doi:
10.1093/pcp/pcw161. [PMID: 28173585] - Mohamed M Mira, Robert D Hill, Claudio Stasolla. Phytoglobins Improve Hypoxic Root Growth by Alleviating Apical Meristem Cell Death.
Plant physiology.
2016 11; 172(3):2044-2056. doi:
10.1104/pp.16.01150. [PMID: 27702845] - Gat Krieger, Doron Shkolnik, Gad Miller, Hillel Fromm. Reactive Oxygen Species Tune Root Tropic Responses.
Plant physiology.
2016 10; 172(2):1209-1220. doi:
10.1104/pp.16.00660. [PMID: 27535793] - Suhas Shinde, Joji Grace Villamor, Wendar Lin, Sandeep Sharma, Paul E Verslues. Proline Coordination with Fatty Acid Synthesis and Redox Metabolism of Chloroplast and Mitochondria.
Plant physiology.
2016 10; 172(2):1074-1088. doi:
10.1104/pp.16.01097. [PMID: 27512016] - Changhua Zhu, Na Yang, Zhengfei Guo, Meng Qian, Lijun Gan. An ethylene and ROS-dependent pathway is involved in low ammonium-induced root hair elongation in Arabidopsis seedlings.
Plant physiology and biochemistry : PPB.
2016 Aug; 105(?):37-44. doi:
10.1016/j.plaphy.2016.04.002. [PMID: 27074220] - Yajie Zhang, Fengping Chen, Jiading Chen, Suqun Huang, Junbin Chen, Jian Huang, Nan Li, Suxia Sun, Xinwei Chu, Longying Zha. Soyasaponin Bb inhibits the recruitment of toll-like receptor 4 (TLR4) into lipid rafts and its signaling pathway by suppressing the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-dependent generation of reactive oxygen species.
Molecular nutrition & food research.
2016 07; 60(7):1532-43. doi:
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Plant biology (Stuttgart, Germany).
2016 Jul; 18(4):658-68. doi:
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Plant signaling & behavior.
2016 05; 11(5):e1180492. doi:
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Plant cell reports.
2016 May; 35(5):1155-68. doi:
10.1007/s00299-016-1952-8. [PMID: 26910861] - Xiangqiang Kong, Zhen Luo, Hezhong Dong, A Egrinya Eneji, Weijiang Li. H2O2 and ABA signaling are responsible for the increased Na+ efflux and water uptake in Gossypium hirsutum L. roots in the non-saline side under non-uniform root zone salinity.
Journal of experimental botany.
2016 Apr; 67(8):2247-61. doi:
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Journal of experimental botany.
2016 Mar; 67(6):1795-804. doi:
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Physiologia plantarum.
2016 Mar; 156(3):252-61. doi:
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World journal of urology.
2016 Jan; 34(1):89-95. doi:
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PloS one.
2016; 11(3):e0150886. doi:
10.1371/journal.pone.0150886. [PMID: 26939003] - Hirokazu Takahashi, Takaki Yamauchi, Imene Rajhi, Naoko K Nishizawa, Mikio Nakazono. Transcript profiles in cortical cells of maize primary root during ethylene-induced lysigenous aerenchyma formation under aerobic conditions.
Annals of botany.
2015 May; 115(6):879-94. doi:
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Life sciences.
2015 Apr; 126(?):69-75. doi:
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Ecotoxicology and environmental safety.
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Journal of plant physiology.
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Bioscience, biotechnology, and biochemistry.
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International forum of allergy & rhinology.
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European heart journal.
2014 Nov; 35(43):3021-32. doi:
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Photochemistry and photobiology.
2014 Sep; 90(5):1043-9. doi:
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American journal of physiology. Cell physiology.
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Protoplasma.
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Journal of lipid research.
2014 07; 55(7):1226-44. doi:
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The Journal of pharmacology and experimental therapeutics.
2014 Jun; 349(3):437-43. doi:
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Journal of experimental botany.
2014 Jan; 65(1):261-73. doi:
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PloS one.
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Redox biology.
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International journal of molecular sciences.
2013 Nov; 14(11):22967-81. doi:
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Journal of plant physiology.
2013 Nov; 170(17):1471-83. doi:
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Hearing research.
2013 Oct; 304(?):145-52. doi:
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Neurochemical research.
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2013 Jul; 29(4):339-44. doi:
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The Plant cell.
2013 Apr; 25(4):1314-28. doi:
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Free radical biology & medicine.
2013 Apr; 57(?):162-75. doi:
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Plant physiology and biochemistry : PPB.
2013 Apr; 65(?):27-31. doi:
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The New phytologist.
2013 Apr; 198(1):179-189. doi:
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International journal of sport nutrition and exercise metabolism.
2013 Apr; 23(2):137-49. doi:
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Journal of experimental botany.
2013 Mar; 64(5):1413-25. doi:
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Brain research.
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PloS one.
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The Journal of pharmacology and experimental therapeutics.
2013 Jan; 344(1):15-22. doi:
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Ecotoxicology and environmental safety.
2012 Dec; 86(?):198-203. doi:
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BMC plant biology.
2012 Aug; 12(?):128. doi:
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The Plant cell.
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Molecular and cellular endocrinology.
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Molecular biology reports.
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Plant physiology.
2012 Apr; 158(4):2013-27. doi:
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Plant physiology and biochemistry : PPB.
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Plant physiology and biochemistry : PPB.
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Cancer biology & therapy.
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British journal of pharmacology.
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International journal of molecular medicine.
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Journal of proteomics.
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Plant physiology.
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Plant, cell & environment.
2011 Jun; 34(6):980-993. doi:
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Eukaryotic cell.
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The Journal of steroid biochemistry and molecular biology.
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Endocrinology.
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Phytopathology.
2010 Sep; 100(9):840-7. doi:
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Molecular plant-microbe interactions : MPMI.
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