Monoacetyldapsone (BioDeep_00001028373)
代谢物信息卡片
Monoacetyldapsone
化学式: C14H14N2O3S (290.0725)
中文名称: N-乙酰氨苯砜
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(=O)NC1=CC=C(C=C1)S(=O)(=O)C2=CC=C(C=C2)N
InChI: InChI=1S/C14H14N2O3S/c1-10(17)16-12-4-8-14(9-5-12)20(18,19)13-6-2-11(15)3-7-13/h2-9H,15H2,1H3,(H,16,17)
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
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PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Rafid A Najim, Makram M Al-Waiz, Rafi A M Al-Razzuqi. Acetylator phenotype in Iraqi patients with atopic dermatitis.
Dermatology online journal.
2006 Dec; 12(7):1. doi:
NULL. [PMID: 17459287] - R A Najim, Y Y Z Farid, T Abed Samad, S A R Shihab. Acetylator phenotype in Iraqi patients with systemic lupus erythematosus.
Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit.
2005 Sep; 11(5-6):1003-8. doi:
NULL. [PMID: 16761671] - Wilson Roberto Malfará, Carolina Paula Pereira, Antonio Cardozo Dos Santos, Regina Helena Costa Queiroz. Effects of H(2)-receptor antagonists on dapsone-induced methaemoglobinaemia in rats.
Pharmacological research.
2002 Apr; 45(4):269-73. doi:
10.1006/phrs.2002.0958. [PMID: 12030789] - M Lu, S M Poloyac, P J McNamara, R A Blouin. The effect of pregnenolone 16alpha-carbonitrile on the pharmacokinetics and metabolism of dapsone in rats.
The Journal of pharmacy and pharmacology.
1999 Jul; 51(7):803-10. doi:
10.1211/0022357991773177. [PMID: 10467955] - R H Queiroz, S A Dreossi, D Carvalho. A rapid, specific, and sensitive method for the determination of acetylation phenotype using dapsone.
Journal of analytical toxicology.
1997 May; 21(3):203-7. doi:
10.1093/jat/21.3.203. [PMID: 9171203] - M R Korrapati, J D Sorkin, R Andres, D C Muller, C M Loi, E S Vesell, R E Vestal. Acetylator phenotype in relation to age and gender in the Baltimore Longitudinal Study of Aging.
Journal of clinical pharmacology.
1997 Feb; 37(2):83-91. doi:
10.1002/j.1552-4604.1997.tb04765.x. [PMID: 9055133] - J Eljaschewitsch, J Padberg, D Schürmann, B Ruf. High-performance liquid chromatography determination of pyrimethamine, dapsone, monoacetyldapsone, sulfadoxine, and N-acetyl-sulfadoxine after rapid solid-phase extraction.
Therapeutic drug monitoring.
1996 Oct; 18(5):592-7. doi:
10.1097/00007691-199610000-00012. [PMID: 8885125] - R M Hoetelmans, J M Otten, C H Koks, M Soesan, J H Beijnen. Combined dapsone and clofazimine intoxication.
Human & experimental toxicology.
1996 Aug; 15(8):625-8. doi:
10.1177/096032719601500805. [PMID: 8863056] - C V Preuss, C K Svensson. Arylacetamide deacetylase activity towards monoacetyldapsone. Species comparison, factors that influence activity, and comparison with 2-acetylaminofluorene and p-nitrophenyl acetate hydrolysis.
Biochemical pharmacology.
1996 Jun; 51(12):1661-8. doi:
10.1016/0006-2952(96)00134-7. [PMID: 8687481] - E K Mberu, D K Muhia, G O Minyiri, E W Njonge, W M Watkins. Measurement of physiological concentrations of dapsone and its monoacetyl metabolite: a miniaturised assay for liquid or filter paper-absorbed samples.
Journal of chromatography. B, Biomedical applications.
1996 Mar; 677(2):385-7. doi:
10.1016/0378-4347(95)00510-2. [PMID: 8704946] - G Gatti, A Loy, R Casazza, F Miletich, M Cruciani, D Bassetti. Pharmacokinetics of dapsone in human immunodeficiency virus-infected children.
Antimicrobial agents and chemotherapy.
1995 May; 39(5):1101-6. doi:
10.1128/aac.39.5.1101. [PMID: 7625796] - M Opravil, B Joos, R Lüthy. Levels of dapsone and pyrimethamine in serum during once-weekly dosing for prophylaxis of Pneumocystis carinii pneumonia and toxoplasmic encephalitis.
Antimicrobial agents and chemotherapy.
1994 May; 38(5):1197-9. doi:
10.1128/aac.38.5.1197. [PMID: 8067765] - M D Edstein, G D Shanks, P Teja-Isavadharm, K H Rieckmann, H K Webster. Oxidative activation of proguanil and dapsone acetylation in Thai soldiers.
British journal of clinical pharmacology.
1994 Jan; 37(1):67-70. doi:
10.1111/j.1365-2125.1994.tb04241.x. [PMID: 8148220] - M D Edstein, K H Rieckmann. Lack of effect of proguanil on the pharmacokinetics of dapsone in healthy volunteers.
Chemotherapy.
1993 Jul; 39(4):235-41. doi:
10.1159/000239131. [PMID: 8325124] - M M Lemnge, A Rønn, H Flachs, I C Bygbjerg. Simultaneous determination of dapsone, monoacetyldapsone and pyrimethamine in whole blood and plasma by high-performance liquid chromatography.
Journal of chromatography.
1993 Apr; 613(2):340-6. doi:
10.1016/0378-4347(93)80152-t. [PMID: 8491823] - Y M Irshaid, H F al-Hadidi, M A Abuirjeie, N M Rawashdeh, N S Gharaibeh. Acetylation of dapsone by human whole blood.
International journal of clinical pharmacology, therapy, and toxicology.
1993 Jan; 31(1):18-22. doi:
NULL. [PMID: 8444513] - F Ebbesen, A Knudsen. The possible risk of bilirubin encephalopathy as predicted by plasma parameters in neonates with previous severe asphyxia.
European journal of pediatrics.
1992 Dec; 151(12):910-2. doi:
10.1007/bf01954128. [PMID: 1473545] - F Ebbesen, A Knudsen, P L Petersen. Reduced albumin binding of MADDS--a measure of bilirubin binding--during pregnancy and delivery.
European journal of obstetrics, gynecology, and reproductive biology.
1992 Sep; 46(2-3):95-100. doi:
10.1016/0028-2243(92)90252-t. [PMID: 1451901] - M D Coleman, L E Rhodes, A K Scott, J L Verbov, P S Friedmann, A M Breckenridge, B K Park. The use of cimetidine to reduce dapsone-dependent methaemoglobinaemia in dermatitis herpetiformis patients.
British journal of clinical pharmacology.
1992 Sep; 34(3):244-9. doi:
10.1111/j.1365-2125.1992.tb04131.x. [PMID: 1389948] - Y M Irshaid, H F al-Hadidi, M A Abuirjeie, N M Rawashdeh. N-acetylation phenotyping using dapsone in a Jordanian population.
British journal of clinical pharmacology.
1991 Sep; 32(3):289-93. doi:
10.1111/j.1365-2125.1991.tb03901.x. [PMID: 1777365] - M A Abuirjeie, Y M Irshaid, H F al-Hadidi, N M Rawashdeh. Simultaneous high performance liquid chromatographic determination of dapsone and monoacetyldapsone in human plasma and urine.
Journal of clinical pharmacy and therapeutics.
1991 Aug; 16(4):247-55. doi:
10.1111/j.1365-2710.1991.tb00311.x. [PMID: 1939403] - E Esbjörner, P Larsson, P Leissner, L Wranne. The serum reserve albumin concentration for monoacetyldiaminodiphenyl sulphone and auditory evoked responses during neonatal hyperbilirubinaemia.
Acta paediatrica Scandinavica.
1991 Apr; 80(4):406-12. doi:
10.1111/j.1651-2227.1991.tb11874.x. [PMID: 2058389] - E Esbjörner. Albumin binding properties in relation to bilirubin and albumin concentrations during the first week of life.
Acta paediatrica Scandinavica.
1991 Apr; 80(4):400-5. doi:
10.1111/j.1651-2227.1991.tb11873.x. [PMID: 2058388] - M D Edstein, K H Rieckmann, J R Veenendaal. Multiple-dose pharmacokinetics and in vitro antimalarial activity of dapsone plus pyrimethamine (Maloprim) in man.
British journal of clinical pharmacology.
1990 Aug; 30(2):259-65. doi:
10.1111/j.1365-2125.1990.tb03773.x. [PMID: 2206787] - M D Edstein, J R Veenendaal, K H Rieckmann. Multiple-dose kinetics in healthy volunteers and in vitro antimalarial activity of proguanil plus dapsone.
Chemotherapy.
1990; 36(3):169-76. doi:
10.1159/000238763. [PMID: 2186899] - A Robertson, W Karp, R Brodersen. Comparison of the binding characteristics of serum albumins from various animal species.
Developmental pharmacology and therapeutics.
1990; 15(2):106-11. doi:
10.1159/000457629. [PMID: 2078971] - R Brodersen, B Honoré. Drug binding properties of neonatal albumin.
Acta paediatrica Scandinavica.
1989 May; 78(3):342-6. doi:
10.1111/j.1651-2227.1989.tb11089.x. [PMID: 2545072] - S K Garg, B Kumar, V Bakaya, R Lal, V K Shukla, S Kaur. Plasma dapsone and its metabolite monoacetyldapsone levels in leprotic patients.
International journal of clinical pharmacology, therapy, and toxicology.
1988 Nov; 26(11):552-4. doi:
NULL. [PMID: 3243659] - Y Horai, T Ishizaki. N-acetylation polymorphism of dapsone in a Japanese population.
British journal of clinical pharmacology.
1988 Apr; 25(4):487-94. doi:
10.1111/j.1365-2125.1988.tb03333.x. [PMID: 3382590] - F A Pieters, F Woonink, J Zuidema. A field trial among leprosy patients in Nigeria with depot injections of dapsone and monoacetyldapsone.
International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association.
1988 Mar; 56(1):10-20. doi:
NULL. [PMID: 3373080] - Y Horai, H H Zhou, L M Zhang, T Ishizaki. N-acetylation phenotyping with dapsone in a mainland Chinese population.
British journal of clinical pharmacology.
1988 Jan; 25(1):81-7. doi:
10.1111/j.1365-2125.1988.tb03285.x. [PMID: 3370194] - F Ebbesen, J Hess, R Brodersen. Albumin binding of MADDS--a measure of bilirubin binding--in women during pregnancy and after delivery and in their infants.
Acta obstetricia et gynecologica Scandinavica.
1988; 67(5):405-9. doi:
10.3109/00016348809004249. [PMID: 3218457] - S Fink, W Karp, A Robertson. Ceftriaxone effect on bilirubin-albumin binding.
Pediatrics.
1987 Dec; 80(6):873-5. doi:
. [PMID: 3684399] - F A Pieters, B J Vincken, J Zuidema. Dapsone and monoacetyldapsone determined in serum and saliva by a sensitive high-performance liquid chromatographic method with a single extraction step.
Journal of chromatography.
1987 Nov; 422(?):322-7. doi:
10.1016/0378-4347(87)80470-x. [PMID: 3437021] - P A Philip, S L Gayed, H J Rogers, P Crome. Influence of age, sex and body weight on the dapsone acetylation phenotype.
British journal of clinical pharmacology.
1987 Jun; 23(6):709-13. doi:
10.1111/j.1365-2125.1987.tb03105.x. [PMID: 3606931] - P A Philip, H J Rogers, P G Harper. Acetylation and oxidation phenotypes in malignant lymphoma.
Cancer chemotherapy and pharmacology.
1987; 20(3):235-8. doi:
10.1007/bf00570492. [PMID: 3677298] - F A Pieters, J Zuidema. Intra-adipose administration of monoacetyldapsone to healthy volunteers.
International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association.
1986 Dec; 54(4):510-6. doi:
NULL. [PMID: 3819527] - F A Pieters, J Zuidema. The pharmacokinetics of dapsone after oral administration to healthy volunteers.
British journal of clinical pharmacology.
1986 Oct; 22(4):491-4. doi:
10.1111/j.1365-2125.1986.tb02924.x. [PMID: 3768260] - F Ebbesen, N Foged, R Brodersen. Reduced albumin binding of MADDS--a measure for bilirubin binding--in sick children.
Acta paediatrica Scandinavica.
1986 Jul; 75(4):550-4. doi:
10.1111/j.1651-2227.1986.tb10248.x. [PMID: 3751549] - A Robertson, W Karp. Albumin binding of bumetanide.
Developmental pharmacology and therapeutics.
1986; 9(4):241-8. doi:
10.1159/000457099. [PMID: 3757731] - S W Sanders, J J Zone. The relationship between dapsone dose, serum concentration and disease severity in dermatitis herpetiformis.
Arzneimittel-Forschung.
1986; 36(1):146-9. doi:
NULL. [PMID: 3954818] - A M Dhople. Armadillo as a model for studying chemotherapy of leprosy: preliminary studies.
Indian journal of leprosy.
1986 Jan; 58(1):19-28. doi:
NULL. [PMID: 3745995] - I F Cook, J P Cochrane, M D Edstein. Race-linked differences in serum concentrations of dapsone, monoacetyldapsone and pyrimethamine during malaria prophylaxis.
Transactions of the Royal Society of Tropical Medicine and Hygiene.
1986; 80(6):897-901. doi:
10.1016/0035-9203(86)90250-6. [PMID: 3299903] - Y Horai, T Ishizaki. Rapid and sensitive liquid chromatographic method for the determination of dapsone and monoacetyldapsone in plasma and urine.
Journal of chromatography.
1985 Dec; 345(2):447-52. doi:
10.1016/0378-4347(85)80187-0. [PMID: 4086615] - R Brodersen. Fusidic acid binding to serum albumin and interaction with binding of bilirubin.
Acta paediatrica Scandinavica.
1985 Nov; 74(6):874-80. doi:
10.1111/j.1651-2227.1985.tb10051.x. [PMID: 4090962] - W B Karp, M Kinsley, S B Subramanyam, A F Robertson. Binding properties of glycosylated albumin and acetaldehyde albumin.
Alcoholism, clinical and experimental research.
1985 Sep; 9(5):429-32. doi:
10.1111/j.1530-0277.1985.tb05577.x. [PMID: 3904507] - C K Ho, A F Robertson, W B Karp. Hematin and bilirubin binding to human serum albumin and newborn serum.
Acta paediatrica Scandinavica.
1985 May; 74(3):372-7. doi:
10.1111/j.1651-2227.1985.tb10986.x. [PMID: 4003060] - I F Cook. Inadequate prophylaxis of malaria with dapsone-pyrimethamine.
The Medical journal of Australia.
1985 Mar; 142(6):340-2. doi:
10.5694/j.1326-5377.1985.tb113407.x. [PMID: 3883112] - H S Lee, T Y Ti, P S Lee, C L Yap. Simultaneous estimation of serum concentrations of dapsone, monoacetyldapsone, and pyrimethamine in Chinese men on maloprim for malaria prophylaxis using reversed-phase high performance liquid chromatography.
Therapeutic drug monitoring.
1985; 7(4):415-20. doi:
10.1097/00007691-198512000-00009. [PMID: 3909534] - M Edstein. Quantification of antimalarial drugs. II. Simultaneous measurement of dapsone, monoacetyldapsone and pyrimethamine in human plasma.
Journal of chromatography.
1984 May; 307(2):426-31. doi:
NULL. [PMID: 6736190] - P A Philip, M S Roberts, H J Rogers. A rapid method for determination of acetylation phenotype using dapsone.
British journal of clinical pharmacology.
1984 Apr; 17(4):465-9. doi:
10.1111/j.1365-2125.1984.tb02373.x. [PMID: 6721993] - A F Swain, R A Ahmad, H J Rogers, J N Leonard, L Fry. Pharmacokinetic observations on dapsone in dermatitis herpetiformis.
The British journal of dermatology.
1983 Jan; 108(1):91-8. doi:
10.1111/j.1365-2133.1983.tb04583.x. [PMID: 6821646] - R Brodersen, B Friis-Hansen, L Stern. Drug-induced displacement of bilirubin from albumin in the newborn.
Developmental pharmacology and therapeutics.
1983; 6(4):217-29. doi:
10.1159/000457308. [PMID: 6352207] - W J Cashore, W Oh, R Brodersen. Bilirubin-displacing effect of furosemide and sulfisoxazole. An in vitro and in vivo study in neonatal serum.
Developmental pharmacology and therapeutics.
1983; 6(4):230-8. doi:
10.1159/000457309. [PMID: 6617404] - R Brodersen, S Andersen, C Jacobsen, O Sønderskov, F Ebbesen, W J Cashore, S Larsen. Determination of reserve albumin-equivalent for ligand binding, probing two distinct binding functions of the protein.
Analytical biochemistry.
1982 Apr; 121(2):395-408. doi:
10.1016/0003-2697(82)90499-7. [PMID: 7103072] - R Brodersen, L Lakatos, L Karmazsin. D-penicillamine, a non-bilirubin-displacing drug in neonatal jaundice.
Acta paediatrica Scandinavica.
1980 Jan; 69(1):31-5. doi:
10.1111/j.1651-2227.1980.tb07025.x. [PMID: 6892748] - C R Jones, S M Ovenell. Determination of plasma concentrations of dapsone, monoacetyl dapsone and pyrimethamine in human subjects dosed with maloprim.
Journal of chromatography.
1979 Jun; 163(2):179-85. doi:
10.1016/s0378-4347(00)81461-9. [PMID: 541369] - G R Gordon, J H Peters, D C Ghoul, J F Murray, L Levy, J T Biggs. Disposition of dapsone and monoacetyldapsone in rats.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.).
1975 Nov; 150(2):485-92. doi:
10.3181/00379727-150-39062. [PMID: 1208566]
