[1-heptadecanoyloxy-3-[hydroxy-(2,3,5,6-tetrahydroxy-4-phosphonooxycyclohexyl)oxyphosphoryl]oxypropan-2-yl] (5E,8E,11E,14E)-icosa-5,8,11,14-tetraenoate (BioDeep_00001023320)
代谢物信息卡片
[1-heptadecanoyloxy-3-[hydroxy-(2,3,5,6-tetrahydroxy-4-phosphonooxycyclohexyl)oxyphosphoryl]oxypropan-2-yl] (5E,8E,11E,14E)-icosa-5,8,11,14-tetraenoate
化学式: C46H82O16P2 (952.5077832000001)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCCCCCCCCCCCCCC(=O)OCC(COP(=O)(O)OC1C(C(C(C(C1O)O)OP(=O)(O)O)O)O)OC(=O)CCCC=CCC=CCC=CCC=CCCCCC
InChI: InChI=1S/C46H82O16P2/c1-3-5-7-9-11-13-15-17-19-20-21-23-25-27-29-31-33-35-40(48)60-38(36-58-39(47)34-32-30-28-26-24-22-18-16-14-12-10-8-6-4-2)37-59-64(56,57)62-46-43(51)41(49)45(42(50)44(46)52)61-63(53,54)55/h11,13,17,19,21,23,27,29,38,41-46,49-52H,3-10,12,14-16,18,20,22,24-26,28,30-37H2,1-2H3,(H,56,57)(H2,53,54,55)/b13-11+,19-17+,23-21+,29-27+
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Vedrana Marković, Yvon Jaillais. Phosphatidylinositol 4-phosphate: a key determinant of plasma membrane identity and function in plants.
The New phytologist.
2022 08; 235(3):867-874. doi:
10.1111/nph.18258. [PMID: 35586972] - James B Konopka. Plasma Membrane Phosphatidylinositol 4-Phosphate Is Necessary for Virulence of Candida albicans.
mBio.
2022 06; 13(3):e0036622. doi:
10.1128/mbio.00366-22. [PMID: 35467420] - Chen Braun, Xiaorong Xu Parks, Haani Qudsi, Coeli M B Lopes. Membrane pools of phosphatidylinositol-4-phosphate regulate KCNQ1/KCNE1 membrane expression.
Communications biology.
2021 12; 4(1):1392. doi:
10.1038/s42003-021-02909-1. [PMID: 34907346] - Yongqing Yang, Xiuli Han, Liang Ma, Yujiao Wu, Xiao Liu, Haiqi Fu, Guoyong Liu, Xiaoguang Lei, Yan Guo. Dynamic changes of phosphatidylinositol and phosphatidylinositol 4-phosphate levels modulate H+-ATPase and Na+/H+ antiporter activities to maintain ion homeostasis in Arabidopsis under salt stress.
Molecular plant.
2021 12; 14(12):2000-2014. doi:
10.1016/j.molp.2021.07.020. [PMID: 34339895] - Kay Oliver Schink, Kia Wee Tan, Hélène Spangenberg, Domenica Martorana, Marte Sneeggen, Virginie Stévenin, Jost Enninga, Coen Campsteijn, Camilla Raiborg, Harald Stenmark. The phosphoinositide coincidence detector Phafin2 promotes macropinocytosis by coordinating actin organisation at forming macropinosomes.
Nature communications.
2021 11; 12(1):6577. doi:
10.1038/s41467-021-26775-x. [PMID: 34772942] - Hema Adhikari, Walaa E Kattan, Shivesh Kumar, Pei Zhou, John F Hancock, Christopher M Counter. Oncogenic KRAS is dependent upon an EFR3A-PI4KA signaling axis for potent tumorigenic activity.
Nature communications.
2021 09; 12(1):5248. doi:
10.1038/s41467-021-25523-5. [PMID: 34504076] - Andrew King On Wong, Barry Paul Young, Christopher J R Loewen. Ist2 recruits the lipid transporters Osh6/7 to ER-PM contacts to maintain phospholipid metabolism.
The Journal of cell biology.
2021 09; 220(9):. doi:
10.1083/jcb.201910161. [PMID: 34259806] - Noemi Ruiz-Lopez, Jessica Pérez-Sancho, Alicia Esteban Del Valle, Richard P Haslam, Steffen Vanneste, Rafael Catalá, Carlos Perea-Resa, Daniël Van Damme, Selene García-Hernández, Armando Albert, José Vallarino, Jinxing Lin, Jiří Friml, Alberto P Macho, Julio Salinas, Abel Rosado, Johnathan A Napier, Vitor Amorim-Silva, Miguel A Botella. Synaptotagmins at the endoplasmic reticulum-plasma membrane contact sites maintain diacylglycerol homeostasis during abiotic stress.
The Plant cell.
2021 08; 33(7):2431-2453. doi:
10.1093/plcell/koab122. [PMID: 33944955] - Lizhen Song, Yanning Wang, Zhiai Guo, Sin M Lam, Guanghou Shui, Youfa Cheng. NCP2/RHD4/SAC7, SAC6 and SAC8 phosphoinositide phosphatases are required for PtdIns4P and PtdIns(4,5)P2 homeostasis and Arabidopsis development.
The New phytologist.
2021 07; 231(2):713-725. doi:
10.1111/nph.17402. [PMID: 33876422] - Alex G Batrouni, Jeremy M Baskin. The chemistry and biology of phosphatidylinositol 4-phosphate at the plasma membrane.
Bioorganic & medicinal chemistry.
2021 06; 40(?):116190. doi:
10.1016/j.bmc.2021.116190. [PMID: 33965837] - Mouhannad Malek, Anna M Wawrzyniak, Peter Koch, Christian Lüchtenborg, Manuel Hessenberger, Timo Sachsenheimer, Wonyul Jang, Britta Brügger, Volker Haucke. Inositol triphosphate-triggered calcium release blocks lipid exchange at endoplasmic reticulum-Golgi contact sites.
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2021 05; 12(1):2673. doi:
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Journal of visualized experiments : JoVE.
2021 03; ?(169):. doi:
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2021 03; 118(9):. doi:
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Cellular and molecular life sciences : CMLS.
2021 Mar; 78(6):2839-2856. doi:
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The FEBS journal.
2021 01; 288(2):360-381. doi:
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Methods in molecular biology (Clifton, N.J.).
2021; 2251(?):73-89. doi:
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Journal of cell science.
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Molecular biology of the cell.
2020 12; 31(25):2816-2825. doi:
10.1091/mbc.e20-03-0173. [PMID: 33026967] - Etienne Pays. The Mechanism of Kidney Disease Due to APOL1 Risk Variants.
Journal of the American Society of Nephrology : JASN.
2020 11; 31(11):2502-2505. doi:
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The Journal of cell biology.
2020 07; 219(7):. doi:
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Molecular biology of the cell.
2020 05; 31(11):1183-1199. doi:
10.1091/mbc.e20-02-0161. [PMID: 32186963] - Sophie Uzureau, Laurence Lecordier, Pierrick Uzureau, Dorle Hennig, Jonas H Graversen, Fabrice Homblé, Pepe Ekulu Mfutu, Fanny Oliveira Arcolino, Ana Raquel Ramos, Rita M La Rovere, Tomas Luyten, Marjorie Vermeersch, Patricia Tebabi, Marc Dieu, Bart Cuypers, Stijn Deborggraeve, Marion Rabant, Christophe Legendre, Søren K Moestrup, Elena Levtchenko, Geert Bultynck, Christophe Erneux, David Pérez-Morga, Etienne Pays. APOL1 C-Terminal Variants May Trigger Kidney Disease through Interference with APOL3 Control of Actomyosin.
Cell reports.
2020 03; 30(11):3821-3836.e13. doi:
10.1016/j.celrep.2020.02.064. [PMID: 32187552] - Gergő Gulyás, Mira Sohn, Yeun Ju Kim, Péter Várnai, Tamas Balla. ORP3 phosphorylation regulates phosphatidylinositol 4-phosphate and Ca2+ dynamics at plasma membrane-ER contact sites.
Journal of cell science.
2020 03; 133(6):. doi:
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BMC biology.
2020 03; 18(1):28. doi:
10.1186/s12915-020-0758-x. [PMID: 32169085] - James P Zewe, April M Miller, Sahana Sangappa, Rachel C Wills, Brady D Goulden, Gerald R V Hammond. Probing the subcellular distribution of phosphatidylinositol reveals a surprising lack at the plasma membrane.
The Journal of cell biology.
2020 03; 219(3):. doi:
10.1083/jcb.201906127. [PMID: 32211893] - Chunguang Ren, Qianying Yuan, Xiaoying Jian, Paul A Randazzo, Wenwen Tang, Dianqing Wu. Small GTPase ARF6 Is a Coincidence-Detection Code for RPH3A Polarization in Neutrophil Polarization.
Journal of immunology (Baltimore, Md. : 1950).
2020 02; 204(4):1012-1021. doi:
10.4049/jimmunol.1901080. [PMID: 31924649] - Mehdi Doumane, Marie-Cécile Caillaud. Assessing Extrinsic Membrane Protein Dependency to PI4P Using a Plasma Membrane to Endosome Relocalization Transient Assay in Nicotiana benthamiana.
Methods in molecular biology (Clifton, N.J.).
2020; 2177(?):95-108. doi:
10.1007/978-1-0716-0767-1_9. [PMID: 32632808] - Nicolas-Frédéric Lipp, Romain Gautier, Maud Magdeleine, Maxime Renard, Véronique Albanèse, Alenka Čopič, Guillaume Drin. An electrostatic switching mechanism to control the lipid transfer activity of Osh6p.
Nature communications.
2019 09; 10(1):3926. doi:
10.1038/s41467-019-11780-y. [PMID: 31477717] - Carlos Rubilar-Hernández, Claudio Osorio-Navarro, Francisca Cabello, Lorena Norambuena. PI4KIIIβ Activity Regulates Lateral Root Formation Driven by Endocytic Trafficking to the Vacuole.
Plant physiology.
2019 09; 181(1):112-126. doi:
10.1104/pp.19.00695. [PMID: 31285293] - Taylor E Miller, Karen M Henkels, Mary Huddleston, Richard Salisbury, Saber M Hussain, Atsuo T Sasaki, Kwang-Jin Cho. Depletion of phosphatidylinositol 4-phosphate at the Golgi translocates K-Ras to mitochondria.
Journal of cell science.
2019 08; 132(16):. doi:
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Developmental cell.
2019 04; 49(2):206-219.e7. doi:
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Molecular biology of the cell.
2019 04; 30(9):1069-1084. doi:
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Journal of anatomy.
2019 04; 234(4):502-514. doi:
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Science advances.
2019 03; 5(3):eaat4872. doi:
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Journal of lipid research.
2019 02; 60(2):269-275. doi:
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Free radical biology & medicine.
2019 01; 130(?):426-435. doi:
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Oncogene.
2019 01; 38(3):332-344. doi:
10.1038/s41388-018-0448-0. [PMID: 30111818] - Mira Sohn, Daniel J Toth, Tamas Balla. Monitoring Non-vesicular Transport of Phosphatidylserine and Phosphatidylinositol 4-Phosphate in Intact Cells by BRET Analysis.
Methods in molecular biology (Clifton, N.J.).
2019; 1949(?):13-22. doi:
10.1007/978-1-4939-9136-5_2. [PMID: 30790245] - Shinya Mochizuki, Harukata Miki, Ruyun Zhou, Yukiharu Kido, Wataru Nishimura, Motoshi Kikuchi, Yasuko Noda. Oxysterol-binding protein-related protein (ORP) 6 localizes to the ER and ER-plasma membrane contact sites and is involved in the turnover of PI4P in cerebellar granule neurons.
Experimental cell research.
2018 09; 370(2):601-612. doi:
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Science signaling.
2018 09; 11(547):. doi:
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Journal of cell science.
2018 08; 131(15):. doi:
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Journal of cell science.
2018 07; 131(14):. doi:
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Cell reports.
2018 06; 23(10):2881-2890. doi:
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Developmental cell.
2018 05; 45(4):465-480.e11. doi:
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The Journal of cell biology.
2018 05; 217(5):1797-1813. doi:
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European journal of cell biology.
2018 May; 97(4):269-278. doi:
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Journal of cell science.
2018 01; 131(2):. doi:
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Journal of cell science.
2018 01; 131(1):. doi:
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PloS one.
2018; 13(6):e0199829. doi:
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Nature.
2017 12; 552(7685):410-414. doi:
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Lipids in health and disease.
2017 Dec; 16(1):245. doi:
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The Journal of biological chemistry.
2017 11; 292(46):18862-18877. doi:
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Nature communications.
2017 10; 8(1):757. doi:
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Biochimica et biophysica acta. Biomembranes.
2017 Oct; 1859(10):1880-1890. doi:
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The Journal of biological chemistry.
2017 08; 292(34):14292-14307. doi:
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Kidney international.
2017 07; 92(1):125-139. doi:
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The New phytologist.
2017 May; 214(3):1172-1187. doi:
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Frontiers in cellular and infection microbiology.
2017; 7(?):397. doi:
10.3389/fcimb.2017.00397. [PMID: 28944216] - Ganiyu Olabanji Alli-Balogun, Christina A Gewinner, Ruth Jacobs, Janos Kriston-Vizi, Mark G Waugh, Shane Minogue. Phosphatidylinositol 4-kinase IIβ negatively regulates invadopodia formation and suppresses an invasive cellular phenotype.
Molecular biology of the cell.
2016 12; 27(25):4033-4042. doi:
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Molecular biology of the cell.
2016 12; 27(24):3828-3840. doi:
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