4-[[5-amino-1-[[2-carboxy-2-hydroxy-1-[6-[[2-[[3-hydroxy-1-[(1-hydroxy-2-oxopiperidin-3-yl)amino]-1-oxopropan-2-yl]amino]-2-oxoethyl]carbamoyl]-1,4,5,6-tetrahydropyrimidin-2-yl]ethyl]amino]-1-oxopentan-2-yl]amino]-3-[[5-[(4-amino-4-oxobutanoyl)amino]-8,9-dihydroxy-2,3,4,4a-tetrahydro-1H-pyrimido[1,2-a]quinoline-1-carbonyl]amino]-4-oxobutanoic acid (BioDeep_00001006093)
代谢物信息卡片
化学式: C44H62N14O18 (1074.4366312)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CC(C(=O)N(C1)O)NC(=O)C(CO)NC(=O)CNC(=O)C2CCN=C(N2)C(C(C(=O)O)O)NC(=O)C(CCCN)NC(=O)C(CC(=O)O)NC(=O)C3CCNC4N3C5=CC(=C(C=C5C=C4NC(=O)CCC(=O)N)O)O
InChI: InChI=1S/C44H62N14O18/c45-9-1-3-20(39(69)56-34(35(67)44(74)75)36-47-10-7-21(52-36)38(68)49-17-32(64)51-25(18-59)41(71)54-22-4-2-12-57(76)43(22)73)53-40(70)24(15-33(65)66)55-42(72)26-8-11-48-37-23(50-31(63)6-5-30(46)62)13-19-14-28(60)29(61)16-27(19)58(26)37/h13-14,16,20-22,24-26,34-35,37,48,59-61,67,76H,1-12,15,17-18,45H2,(H2,46,62)(H,47,52)(H,49,68)(H,50,63)(H,51,64)(H,53,70)(H,54,71)(H,55,72)(H,56,69)(H,65,66)(H,74,75)
描述信息
D064449 - Sequestering Agents > D002614 - Chelating Agents > D007502 - Iron Chelating Agents
同义名列表
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Grzegorz Czerwonka, Dawid Gmiter, Anna Guzy, Patrycja Rogala, Agnieszka Jabłońska-Wawrzycka, Andrzej Borkowski, Tomasz Cłapa, Dorota Narożna, Paweł Kowalczyk, Marcin Syczewski, Marcin Drabik, Magdalena Dańczuk, Wiesław Kaca. A benzimidazole-based ruthenium(IV) complex inhibits Pseudomonas aeruginosa biofilm formation by interacting with siderophores and the cell envelope, and inducing oxidative stress.
Biofouling.
2019 01; 35(1):59-74. doi:
10.1080/08927014.2018.1564818
. [PMID: 30727772] - Viviane Antonietti, Stéphanie Boudesocque, Laurent Dupont, Natacha Farvacques, Christine Cézard, Sophie Da Nascimento, Jean-François Raimbert, Larissa Socrier, Thierry-Johann Robin, Sandrine Morandat, Karim El Kirat, Catherine Mullié, Pascal Sonnet. Synthesis, iron(III) complexation properties, molecular dynamics simulations and P. aeruginosa siderophore-like activity of two pyoverdine analogs.
European journal of medicinal chemistry.
2017 Sep; 137(?):338-350. doi:
10.1016/j.ejmech.2017.06.010
. [PMID: 28614758] - Olivier Cunrath, Valérie A Geoffroy, Isabelle J Schalk. Metallome of Pseudomonas aeruginosa: a role for siderophores.
Environmental microbiology.
2016 10; 18(10):3258-3267. doi:
10.1111/1462-2920.12971
. [PMID: 26147433] - Fabrizia Minandri, Francesco Imperi, Emanuela Frangipani, Carlo Bonchi, Daniela Visaggio, Marcella Facchini, Paolo Pasquali, Alessandra Bragonzi, Paolo Visca. Role of Iron Uptake Systems in Pseudomonas aeruginosa Virulence and Airway Infection.
Infection and immunity.
2016 08; 84(8):2324-2335. doi:
10.1128/iai.00098-16
. [PMID: 27271740] - Carlo Bonchi, Emanuela Frangipani, Francesco Imperi, Paolo Visca. Pyoverdine and proteases affect the response of Pseudomonas aeruginosa to gallium in human serum.
Antimicrobial agents and chemotherapy.
2015 Sep; 59(9):5641-6. doi:
10.1128/aac.01097-15
. [PMID: 26149986] - Mélissa Hannauer, Armelle Braud, Françoise Hoegy, Pascale Ronot, Anne Boos, Isabelle J Schalk. The PvdRT-OpmQ efflux pump controls the metal selectivity of the iron uptake pathway mediated by the siderophore pyoverdine in Pseudomonas aeruginosa.
Environmental microbiology.
2012 Jul; 14(7):1696-708. doi:
10.1111/j.1462-2920.2011.02674.x
. [PMID: 22187978] - Jun Okuda, Masashi Okamoto, Naoki Hayashi, Shinji Sawada, Shu Minagawa, Naomasa Gotoh. Complementation of the exoS gene in the pvdE pyoverdine synthesis gene-deficient mutant of Pseudomonas aeruginosa results in recovery of the pvdE gene-mediated penetration through the intestinal epithelial cell barrier but not the pvdE-mediated virulence in silkworms.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.
2012 Jun; 18(3):332-40. doi:
10.1007/s10156-011-0340-0
. [PMID: 22080193] - E A Finlayson, P D Brown. Comparison of antibiotic resistance and virulence factors in pigmented and non-pigmented Pseudomonas aeruginosa.
The West Indian medical journal.
2011 Jan; 60(1):24-32. doi:
. [PMID: 21809707]
- Derek D Doorneweerd, Walter A Henne, Ronald G Reifenberger, Philip S Low. Selective capture and identification of pathogenic bacteria using an immobilized siderophore.
Langmuir : the ACS journal of surfaces and colloids.
2010 Oct; 26(19):15424-9. doi:
10.1021/la101962w
. [PMID: 20704340] - Armelle Braud, Françoise Hoegy, Karine Jezequel, Thierry Lebeau, Isabelle J Schalk. New insights into the metal specificity of the Pseudomonas aeruginosa pyoverdine-iron uptake pathway.
Environmental microbiology.
2009 May; 11(5):1079-91. doi:
10.1111/j.1462-2920.2008.01838.x
. [PMID: 19207567] - David C Laux, Joy M Corson, Michael Givskov, Morten Hentzer, Annette Møller, Kathleen A Wosencroft, Joan C Olson, Karen A Krogfelt, Joanna B Goldberg, Paul S Cohen. Lysophosphatidic acid inhibition of the accumulation of Pseudomonas aeruginosa PAO1 alginate, pyoverdin, elastase and LasA.
Microbiology (Reading, England).
2002 Jun; 148(Pt 6):1709-1723. doi:
10.1099/00221287-148-6-1709
. [PMID: 12055291] - C Lenz, M Schäfer, H Budzikiewicz. Improved ternary matrices for the analysis of ferri-pyoverdins by fast atom bombardment mass spectrometry.
Journal of mass spectrometry : JMS.
1998 Oct; 33(10):984-7. doi:
10.1002/(sici)1096-9888(1998100)33:10<984::aid-jms712>3.0.co;2-6
. [PMID: 9821329] - M C Pájaro, I L Barberis, I Albesa. [Pseudomonas fluorescens: production of pyoverdine in human blood at 4 degrees C and cytotoxic effect of the pigment].
Revista latinoamericana de microbiologia.
1995 Jan; 37(1):1-6. doi:
NULL
. [PMID: 7784726] - C Wolz, K Hohloch, A Ocaktan, K Poole, R W Evans, N Rochel, A M Albrecht-Gary, M A Abdallah, G Döring. Iron release from transferrin by pyoverdin and elastase from Pseudomonas aeruginosa.
Infection and immunity.
1994 Sep; 62(9):4021-7. doi:
10.1128/iai.62.9.4021-4027.1994
. [PMID: 8063422] - M C Pájaro, I L Barberis, S D Godino, I Albesa. [Pyoverdin from Pseudomonas fluorescens: binding to the globulin fraction of serum and its effect on serological reaction titers].
Revista latinoamericana de microbiologia.
1994 Apr; 36(2):79-85. doi:
NULL
. [PMID: 7973183] - R W Prince, C D Cox, M L Vasil. Coordinate regulation of siderophore and exotoxin A production: molecular cloning and sequencing of the Pseudomonas aeruginosa fur gene.
Journal of bacteriology.
1993 May; 175(9):2589-98. doi:
10.1128/jb.175.9.2589-2598.1993
. [PMID: 8478325] - M C Pájaro, I Albesa. [Production of pyoverdin by Pseudomonas fluorescens in human blood at 4 degrees C: association with proteins and the cytotoxic effect of the pigment].
Revista Argentina de microbiologia.
1990 Jan; 22(1):24-30. doi:
NULL
. [PMID: 2125740] - C D Cox. Role of pyocyanin in the acquisition of iron from transferrin.
Infection and immunity.
1986 Apr; 52(1):263-70. doi:
10.1128/iai.52.1.263-270.1986
. [PMID: 2937736] - R Ankenbauer, S Sriyosachati, C D Cox. Effects of siderophores on the growth of Pseudomonas aeruginosa in human serum and transferrin.
Infection and immunity.
1985 Jul; 49(1):132-40. doi:
10.1128/iai.49.1.132-140.1985
. [PMID: 3159677] - C D Cox, P Adams. Siderophore activity of pyoverdin for Pseudomonas aeruginosa.
Infection and immunity.
1985 Apr; 48(1):130-8. doi:
10.1128/iai.48.1.130-138.1985
. [PMID: 3156815] - C D Cox. Iron transport and serum resistance in Pseudomonas aeruginosa.
Antibiotics and chemotherapy.
1985; 36(?):1-12. doi:
10.1159/000410466
. [PMID: 3159335]