4,4,6a,6b,11,11,14b-heptamethyl-2,3,4a,5,6,6a,7,8,9,10,12,13,14,14a-tetradecahydro-1H-picen-3-ol (BioDeep_00001006085)
代谢物信息卡片
4,4,6a,6b,11,11,14b-heptamethyl-2,3,4a,5,6,6a,7,8,9,10,12,13,14,14a-tetradecahydro-1H-picen-3-ol
化学式: C29H48O (412.37049579999996)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1(CCC2=C(C1)C3CCC4C5(CCC(C(C5CCC4(C3(CC2)C)C)(C)C)O)C)C
InChI: InChI=1S/C29H48O/c1-25(2)14-10-19-11-16-28(6)21(20(19)18-25)8-9-23-27(5)15-13-24(30)26(3,4)22(27)12-17-29(23,28)7/h21-24,30H,8-18H2,1-7H3
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Remi Patouret, Sofia Barluenga, Nicolas Winssinger. Withaferin A, a polyfunctional pharmacophore that includes covalent engagement of IPO5, is an inhibitor of influenza A replication.
Bioorganic & medicinal chemistry.
2022 09; 69(?):116883. doi:
10.1016/j.bmc.2022.116883. [PMID: 35772286] - Debasis Mitra, Devvret Verma, Bhaswatimayee Mahakur, Anshul Kamboj, Rakesh Srivastava, Sugam Gupta, Ajita Pandey, Bhawna Arora, Kumud Pant, P Panneerselvam, Arabinda Ghosh, Durga P Barik, Pradeep K Das Mohapatra. Molecular docking and simulation studies of natural compounds of Vitex negundo L. against papain-like protease (PLpro) of SARS CoV-2 (coronavirus) to conquer the pandemic situation in the world.
Journal of biomolecular structure & dynamics.
2022 08; 40(12):5665-5686. doi:
10.1080/07391102.2021.1873185. [PMID: 33459176] - Hong Feng, Yan Hu, Shaoyu Zhou, Yuanfu Lu. Farnesoid X receptor contributes to oleanolic acid-induced cholestatic liver injury in mice.
Journal of applied toxicology : JAT.
2022 Aug; 42(8):1323-1336. doi:
10.1002/jat.4298. [PMID: 35128688] - Jing Zhang, Yang He, Ying Zhou, Liping Hong, Zhansheng Jiang, Ying Zhao, Zhanyu Pan. Epifriedelinol Ameliorates DMBA-Induced Breast Cancer in Albino Rats by Regulating the PI3K/AKT Pathway.
The Tohoku journal of experimental medicine.
2022 Jul; 257(4):283-289. doi:
10.1620/tjem.2022.j030. [PMID: 35598971] - S P Piragauta, J L Higuita-Castro, N Arbeláez, A M Restrepo, R Archbold, W Quiñones, F Torres, F Echeverri, G Escobar, I D Vélez, A Montoya, S M Robledo. Utility of the combination of hederagenin glucoside saponins and chromane hydrazone in the topical treatment of canine cutaneous leishmaniasis. An observational study.
Parasitology research.
2022 May; 121(5):1419-1428. doi:
10.1007/s00436-022-07467-x. [PMID: 35179617] - Kenji Kasuno, Junji Yodoi, Masayuki Iwano. Urinary Thioredoxin as a Biomarker of Renal Redox Dysregulation and a Companion Diagnostic to Identify Responders to Redox-Modulating Therapeutics.
Antioxidants & redox signaling.
2022 05; 36(13-15):1051-1065. doi:
10.1089/ars.2021.0194. [PMID: 34541903] - Hatice Iskender, Eda Dokumacioglu, Kubra Asena Terim Kapakin, Guler Yenice, Behzat Mohtare, Ismail Bolat, Armagan Hayirli. Effects of oleanolic acid on inflammation and metabolism in diabetic rats.
Biotechnic & histochemistry : official publication of the Biological Stain Commission.
2022 May; 97(4):269-276. doi:
10.1080/10520295.2021.1954691. [PMID: 34261397] - Sharon Baumel-Alterzon, Liora S Katz, Gabriel Brill, Clairete Jean-Pierre, Yansui Li, Isabelle Tse, Shyam Biswal, Adolfo Garcia-Ocaña, Donald K Scott. Nrf2 Regulates β-Cell Mass by Suppressing β-Cell Death and Promoting β-Cell Proliferation.
Diabetes.
2022 05; 71(5):989-1011. doi:
10.2337/db21-0581. [PMID: 35192689] - Shota Kaseda, Yuya Sannomiya, Jun Horizono, Jun Kuwazuru, Mary Ann Suico, Sayaka Ogi, Ryoko Sasaki, Hidetoshi Sunamoto, Hirohiko Fukiya, Hayato Nishiyama, Misato Kamura, Saki Niinou, Yuimi Koyama, Futoshi Nara, Tsuyoshi Shuto, Kazuhiro Onuma, Hirofumi Kai. Novel Keap1-Nrf2 Protein-Protein Interaction Inhibitor UBE-1099 Ameliorates Progressive Phenotype in Alport Syndrome Mouse Model.
Kidney360.
2022 04; 3(4):687-699. doi:
10.34067/kid.0004572021. [PMID: 35721612] - Wei Yang, Lijuan He. The protective effect of hederagenin on renal fibrosis by targeting muscarinic acetylcholine receptor.
Bioengineered.
2022 04; 13(4):8689-8698. doi:
10.1080/21655979.2022.2054596. [PMID: 35322725] - Yoshifumi Kurosaki, Akemi Imoto, Fumitaka Kawakami, Motoshi Ouchi, Asuka Morita, Masanori Yokoba, Tsuneo Takenaka, Takafumi Ichikawa, Masato Katagiri, Rikke Nielsen, Naohito Ishii. In vitro study on effect of bardoxolone methyl on cisplatin-induced cellular senescence in human proximal tubular cells.
Molecular and cellular biochemistry.
2022 Mar; 477(3):689-699. doi:
10.1007/s11010-021-04295-y. [PMID: 34973124] - Wenhua Xu, Hongwu Zhang, Qinfeng Zhang, Jialan Xu. β-Amyrin ameliorates diabetic nephropathy in mice and regulates the miR-181b-5p/HMGB2 axis in high glucose-stimulated HK-2 cells.
Environmental toxicology.
2022 Mar; 37(3):637-649. doi:
10.1002/tox.23431. [PMID: 34894065] - Soniya Kumbham, Milan Paul, Asif Itoo, Balaram Ghosh, Swati Biswas. Oleanolic acid-conjugated human serum albumin nanoparticles encapsulating doxorubicin as synergistic combination chemotherapy in oropharyngeal carcinoma and melanoma.
International journal of pharmaceutics.
2022 Feb; 614(?):121479. doi:
10.1016/j.ijpharm.2022.121479. [PMID: 35041911] - Kengo Yamawaki. [Challenges in kidney disease: therapeutic potential of bardoxolone methyl].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica.
2022; 157(4):261-264. doi:
10.1254/fpj.22007. [PMID: 35781457] - Jing Wu, Ran Xue, Muchen Wu, Xuehong Yin, Bangxiang Xie, Qinghua Meng. Nrf2-Mediated Ferroptosis Inhibition Exerts a Protective Effect on Acute-on-Chronic Liver Failure.
Oxidative medicine and cellular longevity.
2022; 2022(?):4505513. doi:
10.1155/2022/4505513. [PMID: 35480867] - Xiang Guo, Jinyu Ji, Jingkai Zhang, Xiaoqiang Hou, Xianyun Fu, Yanan Luo, Zhigang Mei, Zhitao Feng. Anti-inflammatory and osteoprotective effects of Chikusetsusaponin Ⅳa on rheumatoid arthritis via the JAK/STAT signaling pathway.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2021 Dec; 93(?):153801. doi:
10.1016/j.phymed.2021.153801. [PMID: 34758437] - Meina Gao, Hui Li, Chenghao Ye, Kaixian Chen, Hualiang Jiang, Kunqian Yu. Glycan Epitopes and Potential Glycoside Antagonists of DC-SIGN Involved in COVID-19: In Silico Study.
Biomolecules.
2021 10; 11(11):. doi:
10.3390/biom11111586. [PMID: 34827585] - Geng-Ruei Chang, Wei-Li Lin, Tzu-Chun Lin, Huei-Jyuan Liao, Yu-Wen Lu. The Ameliorative Effects of Saikosaponin in Thioacetamide-Induced Liver Injury and Non-Alcoholic Fatty Liver Disease in Mice.
International journal of molecular sciences.
2021 Oct; 22(21):. doi:
10.3390/ijms222111383. [PMID: 34768813] - Santosh Kumar Singh, Shailesh Singh, Rajesh Singh. Targeting novel coronavirus SARS-CoV-2 spike protein with phytoconstituents of Momordica charantia.
Journal of ovarian research.
2021 Sep; 14(1):126. doi:
10.1186/s13048-021-00872-3. [PMID: 34579761] - Joong-Seok Woo, Eun-Seon Yoo, Sung-Hyun Kim, Jae-Han Lee, So-Hee Han, Soo-Hyun Jung, Gi-Hwan Jung, Ji-Youn Jung. Anticancer effects of oleanolic acid on human melanoma cells.
Chemico-biological interactions.
2021 Sep; 347(?):109619. doi:
10.1016/j.cbi.2021.109619. [PMID: 34364837] - Tao Yao, Lei Zhang, Ye Fu, Lina Yao, Chengjie Zhou, Guozhong Chen. Saikosaponin-d Alleviates Renal Inflammation and Cell Apoptosis in a Mouse Model of Sepsis via TCF7/FOSL1/Matrix Metalloproteinase 9 Inhibition.
Molecular and cellular biology.
2021 09; 41(10):e0033221. doi:
10.1128/mcb.00332-21. [PMID: 34309413] - Jie Tang, Mengge Shi, Yan Xu, Zhengcai Ju, Huida Guan, Jun Lin, Gan Li, Han Han, Tong Zhang. Metabolite profiling of Shuganzhi tablets in rats and pharmacokinetics study of four bioactive compounds with liquid chromatography combined with electrospray ionization tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2021 Aug; 1179(?):122827. doi:
10.1016/j.jchromb.2021.122827. [PMID: 34147874] - Rupesh Chikhale, Saurabh K Sinha, Manish Wanjari, Nilambari S Gurav, Muniappan Ayyanar, Satyendra Prasad, Pukar Khanal, Yadu Nandan Dey, Rajesh B Patil, Shailendra S Gurav. Computational assessment of saikosaponins as adjuvant treatment for COVID-19: molecular docking, dynamics, and network pharmacology analysis.
Molecular diversity.
2021 Aug; 25(3):1889-1904. doi:
10.1007/s11030-021-10183-w. [PMID: 33492566] - Mao-Sen Zeng, Wen-Di Yu, Hui-Xian Wang, Jin-Yuan Liu, Pei-Ping Xu. A potential antiviral activity of Esculentoside A against binding interactions of SARS-COV-2 spike protein and angiotensin converting enzyme 2 (ACE2).
International journal of biological macromolecules.
2021 Jul; 183(?):2248-2261. doi:
10.1016/j.ijbiomac.2021.06.017. [PMID: 34111482] - Mlindeli Gamede, Lindokuhle Mabuza, Phikelelani Ngubane, Andile Khathi. Preventing the onset of diabetes-induced chronic kidney disease during prediabetes: The effects of oleanolic acid on selected markers of chronic kidney disease in a diet-induced prediabetic rat model.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 Jul; 139(?):111570. doi:
10.1016/j.biopha.2021.111570. [PMID: 33932738] - Saurabh K Sinha, Anshul Shakya, Satyendra K Prasad, Shashikant Singh, Nilambari S Gurav, Rupali S Prasad, Shailendra S Gurav. An in-silico evaluation of different Saikosaponins for their potency against SARS-CoV-2 using NSP15 and fusion spike glycoprotein as targets.
Journal of biomolecular structure & dynamics.
2021 Jun; 39(9):3244-3255. doi:
10.1080/07391102.2020.1762741. [PMID: 32345124] - Tao He, Chuanxin Liu, Mengyu Li, Mingshuang Wang, Ning Liu, Dan Zhang, Shuang Han, Wenxian Li, Shilin Chen, Ruijuan Yuan, Jianmei Huang. Integrating non-targeted metabolomics and toxicology networks to study the mechanism of Esculentoside A-induced hepatotoxicity in rats.
Journal of biochemical and molecular toxicology.
2021 Jun; 35(6):1-15. doi:
10.1002/jbt.22761. [PMID: 33788351] - Qi Sun, Fei Ye, Hao Liang, Hongbo Liu, Chunmei Li, Roujian Lu, Baoying Huang, Li Zhao, Wenjie Tan, Luhua Lai. Bardoxolone and bardoxolone methyl, two Nrf2 activators in clinical trials, inhibit SARS-CoV-2 replication and its 3C-like protease.
Signal transduction and targeted therapy.
2021 05; 6(1):212. doi:
10.1038/s41392-021-00628-x. [PMID: 34052830] - Muhammad Fakhar-E-Alam Kulyar, Rongrong Li, Khalid Mehmood, Muhammad Waqas, Kun Li, Jiakui Li. Potential influence of Nagella sativa (Black cumin) in reinforcing immune system: A hope to decelerate the COVID-19 pandemic.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2021 May; 85(?):153277. doi:
10.1016/j.phymed.2020.153277. [PMID: 32773257] - Yanyan Song, Haowen Sun, Siyuan Gao, Ke Tang, Yao Zhao, Guanghong Xie, Hang Gao. Saikosaponin a attenuates lead-induced kidney injury through activating Nrf2 signaling pathway.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.
2021 Apr; 242(?):108945. doi:
10.1016/j.cbpc.2020.108945. [PMID: 33278595] - Xiao Yu, Jielu Pan, Nan Shen, Haiyan Zhang, Lu Zou, Hongyu Miao, Lianjun Xing. Development of Saikosaponin D Liposome Nanocarrier with Increased Hepatoprotective Effect Against Alcoholic Hepatitis Mice.
Journal of biomedical nanotechnology.
2021 Apr; 17(4):627-639. doi:
10.1166/jbn.2021.3054. [PMID: 35057889] - Mohammad Nazrul Islam, Khandkar Shaharina Hossain, Partha Protim Sarker, Jannatul Ferdous, Md Abdul Hannan, Md Masudur Rahman, Dinh-Toi Chu, Md Jamal Uddin. Revisiting pharmacological potentials of Nigella sativa seed: A promising option for COVID-19 prevention and cure.
Phytotherapy research : PTR.
2021 Mar; 35(3):1329-1344. doi:
10.1002/ptr.6895. [PMID: 33047412] - Qipeng Zhang, Wenying Chen, Boyang Zhang, Chen Li, Xunyao Zhang, Qian Wang, Yan Wang, Qian Zhou, Xiaohong Li, Xiao Li Shen. Central role of TRAP1 in the ameliorative effect of oleanolic acid on the mitochondrial-mediated and endoplasmic reticulum stress-excitated apoptosis induced by ochratoxin A.
Toxicology.
2021 02; 450(?):152681. doi:
10.1016/j.tox.2021.152681. [PMID: 33465424] - Ruonan Chen, Chenlin Shen, Qingqing Xu, Yaru Liu, Bo Li, Cheng Huang, Taotao Ma, Xiaoming Meng, Maomao Wu, Jun Li. The permeability characteristics and interaction of main components from Si-Ni-San in a MDCK epithelial cell monolayer model.
Xenobiotica; the fate of foreign compounds in biological systems.
2021 Feb; 51(2):239-248. doi:
10.1080/00498254.2017.1359433. [PMID: 28745128] - Emine Kadıoğlu, Yasemin Tekşen, Cengiz Koçak, Fatma Emel Koçak. Beneficial effects of bardoxolone methyl, an Nrf2 activator, on crush-related acute kidney injury in rats.
European journal of trauma and emergency surgery : official publication of the European Trauma Society.
2021 Feb; 47(1):241-250. doi:
10.1007/s00068-019-01216-z. [PMID: 31471671] - James H Lewis, Michel Jadoul, Geoffrey A Block, Melanie P Chin, Deborah A Ferguson, Angie Goldsberry, Colin J Meyer, Megan O'Grady, Pablo E Pergola, Scott A Reisman, W Christian Wigley, Glenn M Chertow. Effects of Bardoxolone Methyl on Hepatic Enzymes in Patients with Type 2 Diabetes Mellitus and Stage 4 CKD.
Clinical and translational science.
2021 01; 14(1):299-309. doi:
10.1111/cts.12868. [PMID: 32860734] - Glenn M Chertow, Gerald B Appel, Sharon Andreoli, Sripal Bangalore, Geoffrey A Block, Arlene B Chapman, Melanie P Chin, Keisha L Gibson, Angie Goldsberry, Kazumoto Iijima, Lesley A Inker, Bertrand Knebelmann, Laura H Mariani, Colin J Meyer, Kandai Nozu, Megan O'Grady, Arnold L Silva, Peter Stenvinkel, Roser Torra, Bradley A Warady, Pablo E Pergola. Study Design and Baseline Characteristics of the CARDINAL Trial: A Phase 3 Study of Bardoxolone Methyl in Patients with Alport Syndrome.
American journal of nephrology.
2021; 52(3):180-189. doi:
10.1159/000513777. [PMID: 33789284] - R P de Lima, P I G Nunes, A F S C Viana, F T B de Oliveira, R A C Silva, A P N N Alves, D A Viana, S G C Fonseca, A A Carvalho, M H Chaves, V S Rao, F A Santos. α,β-Amyrin prevents steatosis and insulin resistance in a high-fat diet-induced mouse model of NAFLD via the AMPK-mTORC1-SREBP1 signaling mechanism.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.
2021; 54(10):e11391. doi:
10.1590/1414-431x2021e11391. [PMID: 34406209] - Zhiqi Shi, Shugang Pan, Luolin Wang, Sha Li. Oleanolic Acid Attenuates Morphine Withdrawal Symptoms in Rodents: Association with Regulation of Dopamine Function.
Drug design, development and therapy.
2021; 15(?):3685-3696. doi:
10.2147/dddt.s326583. [PMID: 34465980] - JinRan Yang, Xinchang Li, Hua Yang, Chenmei Long. Oleanolic Acid Improves the Symptom of Renal Ischemia Reperfusion Injury via the PI3K/AKT Pathway.
Urologia internationalis.
2021; 105(3-4):215-220. doi:
10.1159/000506778. [PMID: 33291121] - Beatriz Gutierrez, Isabel Gallardo, Lorena Ruiz, Yolanda Alvarez, Victoria Cachofeiro, Abelardo Margolles, Marita Hernandez, Maria Luisa Nieto. Oleanolic acid ameliorates intestinal alterations associated with EAE.
Journal of neuroinflammation.
2020 Nov; 17(1):363. doi:
10.1186/s12974-020-02042-6. [PMID: 33246492] - Min Li, Xuwen Li, Limei Zhou, Yongri Jin. Effects of total saponins from Panacis majoris Rhizoma and its degradation products on myocardial ischemia-reperfusion injury in rats.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2020 Oct; 130(?):110538. doi:
10.1016/j.biopha.2020.110538. [PMID: 32731133] - Hironori Kanda, Kengo Yamawaki. Bardoxolone methyl: drug development for diabetic kidney disease.
Clinical and experimental nephrology.
2020 Oct; 24(10):857-864. doi:
10.1007/s10157-020-01917-5. [PMID: 32594372] - Anna Pawełczyk, Lucjusz Zaprutko. Anti-COVID drugs: repurposing existing drugs or search for new complex entities, strategies and perspectives.
Future medicinal chemistry.
2020 10; 12(19):1743-1757. doi:
10.4155/fmc-2020-0204. [PMID: 32698626] - Xiaoli Meng, James C Waddington, Arun Tailor, Adam Lister, Jane Hamlett, Neil Berry, B Kevin Park, Michael B Sporn. CDDO-imidazolide Targets Multiple Amino Acid Residues on the Nrf2 Adaptor, Keap1.
Journal of medicinal chemistry.
2020 09; 63(17):9965-9976. doi:
10.1021/acs.jmedchem.0c01088. [PMID: 32787104] - Pei-Hsiu Hung, Chih-Ming Lin, Jen-Chieh Tsai, Tai-Hao Hsu, Shih-Liang Chang, Ying-I Chen, Chung-Yuh Tzeng. Acetylsalicylic acid-like analgesic effects of Trametes versicolor in Wistar rats.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2020 Sep; 129(?):110328. doi:
10.1016/j.biopha.2020.110328. [PMID: 32535384] - Diandra K Smith, Sarrah L Hasanali, Jiaojiao Wang, Georgios Kallifatidis, Daley S Morera, Andre R Jordan, Martha K Terris, Zachary Klaassen, Roni Bollag, Vinata B Lokeshwar, Bal L Lokeshwar. Promotion of epithelial hyperplasia by interleukin-8-CXCR axis in human prostate.
The Prostate.
2020 09; 80(12):938-949. doi:
10.1002/pros.24026. [PMID: 32542667] - Rafael de la Torre, Marceli Carbó, Mitona Pujadas, Sarah Biel, María-Dolores Mesa, María-Isabel Covas, Manuela Expósito, Juan-Antonio Espejo, Estefanía Sanchez-Rodriguez, Patricia Díaz-Pellicer, Francisco Jimenez-Valladares, Carmen Rosa, Oscar Pozo, Montserrat Fitó. Pharmacokinetics of maslinic and oleanolic acids from olive oil - Effects on endothelial function in healthy adults. A randomized, controlled, dose-response study.
Food chemistry.
2020 Aug; 322(?):126676. doi:
10.1016/j.foodchem.2020.126676. [PMID: 32305871] - Sanggil Choe, Sujin Jeong, Moonhee Jang, Hyesun Yeom, Sungmin Moon, Minji Kang, Wonkyung Yang, Suncheun Kim. Identification of phytolaccosides in biological samples from pokeweed intoxication patients using liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2020 Jul; 1149(?):122123. doi:
10.1016/j.jchromb.2020.122123. [PMID: 32480320] - Eshak I Bahbah, Ahmed Negida, Mohamed Salah Nabet. Purposing Saikosaponins for the treatment of COVID-19.
Medical hypotheses.
2020 07; 140(?):109782. doi:
10.1016/j.mehy.2020.109782. [PMID: 32353743] - E A Hashish, S A Elgaml, Aha El-Fattah, S I Shalaby, S Abdelaziz. β-Amyrin supplementation ameliorates the toxic effect of glycerol in the kidney of rat model.
Human & experimental toxicology.
2020 Jul; 39(7):930-937. doi:
10.1177/0960327120907136. [PMID: 32081053] - Junbin Chen, Hidayat Ullah, Zhongdaixi Zheng, Xiangfu Gu, Chuhong Su, Lingyu Xiao, Xinglong Wu, Fei Xiong, Qing Li, Longying Zha. Soyasaponins reduce inflammation by downregulating MyD88 expression and suppressing the recruitments of TLR4 and MyD88 into lipid rafts.
BMC complementary medicine and therapies.
2020 Jun; 20(1):167. doi:
10.1186/s12906-020-2864-2. [PMID: 32493316] - David J Leehey. Targeting Inflammation in Diabetic Kidney Disease: Is There a Role for Pentoxifylline?.
Kidney360.
2020 Apr; 1(4):292-299. doi:
10.34067/kid.0001252019. [PMID: 35372914] - Katarzyna Dopierała, Martyna Krajewska, Marek Weiss. Physicochemical Characterization of Oleanolic Acid-Human Serum Albumin Complexes for Pharmaceutical and Biosensing Applications.
Langmuir : the ACS journal of surfaces and colloids.
2020 04; 36(13):3611-3623. doi:
10.1021/acs.langmuir.0c00087. [PMID: 32176505] - Puze Li, Minna Wu, Wancheng Xiong, Jinsong Li, Yunying An, Jie Ren, Yingguang Xie, Hongfei Xue, Dong Yan, Min Li, Genshen Zhong. Saikosaponin-d ameliorates dextran sulfate sodium-induced colitis by suppressing NF-κB activation and modulating the gut microbiota in mice.
International immunopharmacology.
2020 Apr; 81(?):106288. doi:
10.1016/j.intimp.2020.106288. [PMID: 32062075] - Xingjiang Hu, Meihua Lin, Wei Zhu, Yunliang Zheng, Qiao Zhang, Guolan Wu, Yunqing Qiu. Potential Cytotoxicity, Pharmacokinetics, and Excretion Properties of Sapindoside B from the Seeds of Nigella sativa var. hispidula.
Planta medica.
2020 Mar; 86(5):356-363. doi:
10.1055/a-1107-3058. [PMID: 32053836] - Anna Yu Spivak, Rezeda R Khalitova, Darya A Nedopekina, Rinat R Gubaidullin. Antimicrobial properties of amine- and guanidine-functionalized derivatives of betulinic, ursolic and oleanolic acids: Synthesis and structure/activity evaluation.
Steroids.
2020 02; 154(?):108530. doi:
10.1016/j.steroids.2019.108530. [PMID: 31678136] - Dadui Ren, Jia Luo, Yingxue Li, Jing Zhang, Jiahong Yang, Junqiu Liu, Xuemei Zhang, Nengneng Cheng, Hong Xin. Saikosaponin B2 attenuates kidney fibrosis via inhibiting the Hedgehog Pathway.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2020 Feb; 67(?):153163. doi:
10.1016/j.phymed.2019.153163. [PMID: 31901891] - Jing Li, Jinfeng Han, Juan Lv, Shiji Wang, Lai Qu, Yanfang Jiang. Saikosaponin A-Induced Gut Microbiota Changes Attenuate Severe Acute Pancreatitis through the Activation of Keap1/Nrf2-ARE Antioxidant Signaling.
Oxidative medicine and cellular longevity.
2020; 2020(?):9217219. doi:
10.1155/2020/9217219. [PMID: 33204401] - Ewa Szczesny-Malysiak, Marta Stojak, Roberto Campagna, Marek Grosicki, Marek Jamrozik, Patrycja Kaczara, Stefan Chlopicki. Bardoxolone Methyl Displays Detrimental Effects on Endothelial Bioenergetics, Suppresses Endothelial ET-1 Release, and Increases Endothelial Permeability in Human Microvascular Endothelium.
Oxidative medicine and cellular longevity.
2020; 2020(?):4678252. doi:
10.1155/2020/4678252. [PMID: 33123312] - Chia-Yu Lin, Jen-Ai Lee, Po-Yeh Lin, Shih-Chun Hua, Pei-Yun Tsai, Bi-Li Chen, Chia-En Lin, Tzong-Huei Lee, Shih-Ming Chen. Utilizing methylglyoxal and D-lactate in urine to evaluate saikosaponin C treatment in mice with accelerated nephrotoxic serum nephritis.
PloS one.
2020; 15(10):e0241053. doi:
10.1371/journal.pone.0241053. [PMID: 33104740] - Ruijia Fu, Jingjing Liu, Yunwen Xue, Zunjian Zhang, Rui Song. Effects of Animal Strain, Dose, and Cotreatment with Saikosaponin b2 on the Pharmacokinetics of Saikosaponin a in Rats.
European journal of drug metabolism and pharmacokinetics.
2019 Dec; 44(6):827-836. doi:
10.1007/s13318-019-00569-5. [PMID: 31317503] - Lingkuan Meng, Yangqing Su, Fan Yang, Sulong Xiao, Zhili Yin, Jiaxin Liu, Jindong Zhong, Demin Zhou, Fei Yu. Design, synthesis and biological evaluation of amino acids-oleanolic acid conjugates as influenza virus inhibitors.
Bioorganic & medicinal chemistry.
2019 12; 27(23):115147. doi:
10.1016/j.bmc.2019.115147. [PMID: 31635892] - Adnan Jehangir, Muhammad Shahzad, Khadija Shahid, Akbar Waheed, Farhana Ayub. Zinc and iron complexes of oleanolic acid, (OA) attenuate allergic airway inflammation in rats.
Inflammopharmacology.
2019 Dec; 27(6):1179-1192. doi:
10.1007/s10787-019-00597-2. [PMID: 31069605] - Yangqing Su, Lingkuan Meng, Jiaqi Sun, Weijia Li, Liang Shao, Kexuan Chen, Demin Zhou, Fan Yang, Fei Yu. Design, synthesis of oleanolic acid-saccharide conjugates using click chemistry methodology and study of their anti-influenza activity.
European journal of medicinal chemistry.
2019 Nov; 182(?):111622. doi:
10.1016/j.ejmech.2019.111622. [PMID: 31425909] - Weijia Li, Fan Yang, Lingkuan Meng, Jiaqi Sun, Yangqing Su, Liang Shao, Demin Zhou, Fei Yu. Synthesis, Structure Activity Relationship and Anti-influenza A Virus Evaluation of Oleanolic Acid-Linear Amino Derivatives.
Chemical & pharmaceutical bulletin.
2019 Nov; 67(11):1201-1207. doi:
10.1248/cpb.c19-00485. [PMID: 31434835] - Hajime Nagasu, Yuji Sogawa, Kengo Kidokoro, Seiji Itano, Toshiya Yamamoto, Minoru Satoh, Tamaki Sasaki, Takafumi Suzuki, Masayuki Yamamoto, W Christian Wigley, Joel W Proksch, Colin J Meyer, Naoki Kashihara. Bardoxolone methyl analog attenuates proteinuria-induced tubular damage by modulating mitochondrial function.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2019 11; 33(11):12253-12263. doi:
10.1096/fj.201900217r. [PMID: 31431054] - Marie Ito, Masaomi Nangaku. Increased albuminuria in bardoxolone methyl-treated type 2 diabetes patients: mere reflection of eGFR improvement?.
Kidney international.
2019 10; 96(4):823-825. doi:
10.1016/j.kint.2019.05.033. [PMID: 31543152] - Iva Potočnjak, Lidija Šimić, Iva Vukelić, Robert Domitrović. Oleanolic acid attenuates cisplatin-induced nephrotoxicity in mice and chemosensitizes human cervical cancer cells to cisplatin cytotoxicity.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2019 Oct; 132(?):110676. doi:
10.1016/j.fct.2019.110676. [PMID: 31306688] - Peter Rossing, Geoffrey A Block, Melanie P Chin, Angie Goldsberry, Hiddo J L Heerspink, Peter A McCullough, Colin J Meyer, David Packham, Pablo E Pergola, Bruce Spinowitz, Stuart M Sprague, David G Warnock, Glenn M Chertow. Effect of bardoxolone methyl on the urine albumin-to-creatinine ratio in patients with type 2 diabetes and stage 4 chronic kidney disease.
Kidney international.
2019 10; 96(4):1030-1036. doi:
10.1016/j.kint.2019.04.027. [PMID: 31377056] - Min-Ju Kim, Hana Park, Seo-Hyeon Choi, Min-Jeong Kong, Ji-Eun Kim, Tae-Cheon Kang. CDDO-Me Attenuates Vasogenic Edema and Astroglial Death by Regulating NF-κB p65 Phosphorylations and Nrf2 Expression Following Status Epilepticus.
International journal of molecular sciences.
2019 Sep; 20(19):. doi:
10.3390/ijms20194862. [PMID: 31574956] - Daisuke Kaya, Kosuke Kaji, Yuki Tsuji, Satoko Yamashita, Koh Kitagawa, Takahiro Ozutsumi, Yukihisa Fujinaga, Hiroaki Takaya, Hideto Kawaratani, Kei Moriya, Tadashi Namisaki, Takemi Akahane, Hitoshi Yoshiji. TGR5 Activation Modulates an Inhibitory Effect on Liver Fibrosis Development Mediated by Anagliptin in Diabetic Rats.
Cells.
2019 09; 8(10):. doi:
10.3390/cells8101153. [PMID: 31561561] - Sonia Celentano, Giovanna Capolongo, Rosa Maria Pollastro. [Bardoxolone: a new potential therapeutic agent in the treatment of autosomal dominant polycystic kidney disease?].
Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia.
2019 Sep; 36(5):. doi:
NULL. [PMID: 31580543] - Si-Wen Zheng, Sheng-Yuan Xiao, Jia Wang, Wei Hou, Ying-Ping Wang. Inhibitory Effects of Ginsenoside Ro on the Growth of B16F10 Melanoma via Its Metabolites.
Molecules (Basel, Switzerland).
2019 Aug; 24(16):. doi:
10.3390/molecules24162985. [PMID: 31426477] - Jingjing Liu, Yunwen Xue, Jianbo Sun, Ruijia Fu, Siqi Ren, Zunjian Zhang, Rui Song. Pharmacokinetics and oral bioavailability studies of three saikogenins in rats using a validated UFLC-MS/MS method.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2019 Aug; 1124(?):265-272. doi:
10.1016/j.jchromb.2019.06.020. [PMID: 31252254] - Yunwen Xue, Jingjing Liu, Ruijia Fu, Lei Gao, Xuping Yang, Zunjian Zhang, Rui Song. In vitro studies on the metabolism of saikogenins and the detection of their metabolites in authentic biosamples.
Journal of pharmaceutical and biomedical analysis.
2019 Aug; 172(?):295-301. doi:
10.1016/j.jpba.2019.04.051. [PMID: 31079023] - Qing Ma, Fang-Fang Gao, Xin He, Kai Li, Yang Gao, Xiao-Long Xu, Nan-Hui Jiang, Liang Ding, Wen-Jing Song, Yan-Qi He, Wen-Ting Pan, Lei Wei, Jing-Wei Zhang. Antitumor effects of saikosaponin b2 on breast cancer cell proliferation and migration.
Molecular medicine reports.
2019 Aug; 20(2):1943-1951. doi:
10.3892/mmr.2019.10385. [PMID: 31257464] - Man You, Rui-Fang Li, Zi-Han Gao, Yuan-Ye Li, Wei-Yi Liu, Jian-Gang Wang, Hong-Wei Wang, San-Qiang Li. [Effects of saikosaponin b_2 on inflammation and energy metabolism in mice with acute liver injury induced by LPS/GalN].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2019 Jul; 44(14):2966-2971. doi:
10.19540/j.cnki.cjcmm.20190521.415. [PMID: 31602841] - Estefanía Butassi, Laura A Svetaz, Shuaizhen Zhou, Jean-Luc Wolfender, Juan C G Cortés, Juan C Ribas, Caridad Díaz, José Pérez-Del Palacio, Francisca Vicente, Susana A Zacchino. The antifungal activity and mechanisms of action of quantified extracts from berries, leaves and roots of Phytolacca tetramera.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2019 Jul; 60(?):152884. doi:
10.1016/j.phymed.2019.152884. [PMID: 30922815] - Jiawei Shen, Xiuqin Cao, Weili Zhou, Jinbo Song. A rapid and sensitive UHPLC-MS/MS method for the determination of celosin A in rat plasma with application to pharmacokinetic study.
Biomedical chromatography : BMC.
2019 Jul; 33(7):e4535. doi:
10.1002/bmc.4535. [PMID: 30883816] - Yinhong Zhu, Xiaobei Chen, Xianlin Rao, Chunhua Zheng, Xiaomou Peng. Saikosaponin a ameliorates lipopolysaccharide and d‑galactosamine-induced liver injury via activating LXRα.
International immunopharmacology.
2019 Jul; 72(?):131-137. doi:
10.1016/j.intimp.2019.03.049. [PMID: 30981078] - Min-Kyun Song, Jin-Hee Lee, In-Geun Ryoo, Sang-Hwan Lee, Sae-Kwang Ku, Mi-Kyoung Kwak. Bardoxolone ameliorates TGF-β1-associated renal fibrosis through Nrf2/Smad7 elevation.
Free radical biology & medicine.
2019 07; 138(?):33-42. doi:
10.1016/j.freeradbiomed.2019.04.033. [PMID: 31059771] - Laura Peeters, Charlie Beirnaert, Anastasia Van der Auwera, Sebastiaan Bijttebier, Tess De Bruyne, Kris Laukens, Luc Pieters, Nina Hermans, Kenn Foubert. Revelation of the metabolic pathway of hederacoside C using an innovative data analysis strategy for dynamic multiclass biotransformation experiments.
Journal of chromatography. A.
2019 Jun; 1595(?):240-247. doi:
10.1016/j.chroma.2019.02.055. [PMID: 30833026] - Luping Wang, Junyu Wang, Hong Zhao, Guoping Jiang, Xiaojie Feng, Wenxia Sui, Hongling Liu. Soyasapogenol B exhibits anti-growth and anti-metastatic activities in clear cell renal cell carcinoma.
Naunyn-Schmiedeberg's archives of pharmacology.
2019 05; 392(5):551-563. doi:
10.1007/s00210-018-01607-w. [PMID: 30607469] - Ryosuke Nakamura, Tatsuya Shirahata, Naruki Konishi, Yasukazu Takanezawa, Yuka Sone, Shimpei Uraguchi, Yoshinori Kobayashi, Masako Kiyono. Oleanolic acid 3-glucoside, a synthetic oleanane-type saponin, alleviates methylmercury toxicity in vitro and in vivo.
Toxicology.
2019 04; 417(?):15-22. doi:
10.1016/j.tox.2019.02.006. [PMID: 30776458] - Mashudu Given Matumba, Ademola Olabode Ayeleso, Trevor Nyakudya, Kennedy Erlwanger, Novel N Chegou, Emmanuel Mukwevho. Long-Term Impact of Neonatal Intake of Oleanolic Acid on the Expression of AMP-Activated Protein Kinase, Adiponectin and Inflammatory Cytokines in Rats Fed with a High Fructose Diet.
Nutrients.
2019 Jan; 11(2):. doi:
10.3390/nu11020226. [PMID: 30678182] - Dana V Rizk, Arnold L Silva, Pablo E Pergola, Robert Toto, David G Warnock, Melanie P Chin, Angie Goldsberry, Megan O'Grady, Colin J Meyer, Peter A McCullough. Effects of Bardoxolone Methyl on Magnesium in Patients with Type 2 Diabetes Mellitus and Chronic Kidney Disease.
Cardiorenal medicine.
2019; 9(5):316-325. doi:
10.1159/000500612. [PMID: 31170712] - Richard Solomon. New Approach to Slowing the Progression of Chronic Kidney Disease.
Cardiorenal medicine.
2019; 9(5):334-336. doi:
10.1159/000502105. [PMID: 31357201] - Kensuke Nakajima, Narumi Maeda, Shigeru Oiso, Hiroko Kariyazono. Decreased Plasma Octanoylated Ghrelin Levels in Mice by Oleanolic Acid.
Journal of oleo science.
2019 Jan; 68(1):103-109. doi:
10.5650/jos.ess18148. [PMID: 30542007] - Yier Xu, Shuilin Chen, Tao Yu, Jiutao Qiao, Guicai Sun. High-throughput metabolomics investigates anti-osteoporosis activity of oleanolic acid via regulating metabolic networks using ultra-performance liquid chromatography coupled with mass spectrometry.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2018 Dec; 51(?):68-76. doi:
10.1016/j.phymed.2018.09.235. [PMID: 30466629] - Glenn M Chertow, Gerald B Appel, Geoffrey A Block, Melanie P Chin, Daniel W Coyne, Angie Goldsberry, Kamyar Kalantar-Zadeh, Colin J Meyer, Mark E Molitch, Pablo E Pergola, Philip Raskin, Arnold L Silva, Bruce Spinowitz, Stuart M Sprague, Peter Rossing. Effects of bardoxolone methyl on body weight, waist circumference and glycemic control in obese patients with type 2 diabetes mellitus and stage 4 chronic kidney disease.
Journal of diabetes and its complications.
2018 Dec; 32(12):1113-1117. doi:
10.1016/j.jdiacomp.2018.09.005. [PMID: 30318163] - Sisi Cao, Meryl E Wastney, Pamela J Lachcik, Hui-Hui Xiao, Connie M Weaver, Man-Sau Wong. Both Oleanolic Acid and a Mixture of Oleanolic and Ursolic Acids Mimic the Effects of Fructus ligustri lucidi on Bone Properties and Circulating 1,25-Dihydroxycholecalciferol in Ovariectomized Rats.
The Journal of nutrition.
2018 12; 148(12):1895-1902. doi:
10.1093/jn/nxy242. [PMID: 30398660] - Weiwei Shi, Dechao Xu, Junhui Gu, Cheng Xue, Bo Yang, Lili Fu, Shuwei Song, Dongmei Liu, Wei Zhou, Jiayi Lv, Ke Sun, Meihan Chen, Changlin Mei. Saikosaponin-d inhibits proliferation by up-regulating autophagy via the CaMKKβ-AMPK-mTOR pathway in ADPKD cells.
Molecular and cellular biochemistry.
2018 Dec; 449(1-2):219-226. doi:
10.1007/s11010-018-3358-0. [PMID: 29675630] - Shuai Wang, Li-Bo Du, Lei Jin, Zhao Wang, Jie Peng, Nai Liao, Yuan-Yuan Zhao, Jie-Ling Zhang, Juergen Pauluhn, Chun-Xu Hai, Xin Wang, Wen-Li Li. Nano-oleanolic acid alleviates metabolic dysfunctions in rats with high fat and fructose diet.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2018 Dec; 108(?):1181-1187. doi:
10.1016/j.biopha.2018.09.150. [PMID: 30372819] - Qunying Xie, Xiangfu Gu, Junbin Chen, Minshun Liu, Fei Xiong, Xinglong Wu, Yajie Zhang, Fengping Chen, Honger Chen, Meijuan Li, Suxia Sun, Xinwei Chu, Longying Zha. Soyasaponins Reduce Inflammation and Improve Serum Lipid Profiles and Glucose Homeostasis in High Fat Diet-Induced Obese Mice.
Molecular nutrition & food research.
2018 10; 62(19):e1800205. doi:
10.1002/mnfr.201800205. [PMID: 30070430] - Ji-Hyun Park, Kyung Mi Jang, Hyun Jin An, Jung-Yeon Kim, Mi-Gyeong Gwon, Hyemin Gu, Byoungduck Park, Kwan-Kyu Park. Pomolic Acid Ameliorates Fibroblast Activation and Renal Interstitial Fibrosis through Inhibition of SMAD-STAT Signaling Pathways.
Molecules (Basel, Switzerland).
2018 Sep; 23(9):. doi:
10.3390/molecules23092236. [PMID: 30177595] - Fatima Zohra Djeziri, Meriem Belarbi, Babar Murtaza, Aziz Hichami, Chahid Benammar, Naim Akhtar Khan. Oleanolic acid improves diet-induced obesity by modulating fat preference and inflammation in mice.
Biochimie.
2018 Sep; 152(?):110-120. doi:
10.1016/j.biochi.2018.06.025. [PMID: 29966735] - Kyoung-Hee Lee, Jiyeong Jeong, Jisu Woo, Chang-Hoon Lee, Chul-Gyu Yoo. Globular Adiponectin Exerts a Pro-Inflammatory Effect via IκB/NF-κB Pathway Activation and Anti-Inflammatory Effect by IRAK-1 Downregulation.
Molecules and cells.
2018 Aug; 41(8):762-770. doi:
10.14348/molcells.2018.0005. [PMID: 30078230] - Larissa Stebounova, Scott M Ebert, Logan T Murry, Christopher M Adams, Daryl J Murry. Rapid and Sensitive Quantification of Ursolic Acid and Oleanolic Acid in Human Plasma Using Ultra-performance Liquid Chromatography-Mass Spectrometry.
Journal of chromatographic science.
2018 Aug; 56(7):644-649. doi:
10.1093/chromsci/bmy038. [PMID: 29701757]