1,2,8,8,15,21-Hexamethyl-19-oxahexacyclo[12.10.0.02,11.05,10.015,22.018,21]tetracos-11-ene-5-carboxylic acid (BioDeep_00001006048)
代谢物信息卡片
化学式: C30H46O3 (454.34467659999996)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1(CCC2(CCC3(C(=CCC4C3(CCC5C4(CCC6C5(CO6)C)C)C)C2C1)C)C(=O)O)C
InChI: InChI=1S/C30H46O3/c1-25(2)13-15-30(24(31)32)16-14-28(5)19(20(30)17-25)7-8-22-26(3)11-10-23-27(4,18-33-23)21(26)9-12-29(22,28)6/h7,20-23H,8-18H2,1-6H3,(H,31,32)
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- S P Piragauta, J L Higuita-Castro, N Arbeláez, A M Restrepo, R Archbold, W Quiñones, F Torres, F Echeverri, G Escobar, I D Vélez, A Montoya, S M Robledo. Utility of the combination of hederagenin glucoside saponins and chromane hydrazone in the topical treatment of canine cutaneous leishmaniasis. An observational study.
Parasitology research.
2022 May; 121(5):1419-1428. doi:
10.1007/s00436-022-07467-x. [PMID: 35179617] - Wei Yang, Lijuan He. The protective effect of hederagenin on renal fibrosis by targeting muscarinic acetylcholine receptor.
Bioengineered.
2022 04; 13(4):8689-8698. doi:
10.1080/21655979.2022.2054596. [PMID: 35322725] - Diego Rodríguez-Hernández, Luiz C A Barbosa, Antonio J Demuner, Amalyn Nain-Perez, Sebastião R Ferreira, Ricardo T Fujiwara, Raquel M de Almeida, Lucie Heller, René Csuk. Leishmanicidal and cytotoxic activity of hederagenin-bistriazolyl derivatives.
European journal of medicinal chemistry.
2017 Nov; 140(?):624-635. doi:
10.1016/j.ejmech.2017.09.045. [PMID: 29024910] - Heng Zhang, Fanbo Jing, Zonglin Zhang. Development and validation of a quantification method for oleanolic acid and hederagenin in rat plasma: application to the pharmacokinetic study.
Biomedical chromatography : BMC.
2017 Feb; 31(2):. doi:
10.1002/bmc.3801. [PMID: 27465077] - Liang Yan, Xiaolin Yang, Zhaoqing Meng, Yongliang Yuan, Wei Xiao, Zhenzhong Wang, Wenze Huang, Zhonglin Yang, Chunfeng Zhang. Simultaneous quantification of Akebia saponin D and its five metabolites in human intestinal bacteria using ultra-performance liquid chromatography triple quadrupole mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2014 Nov; 971(?):81-8. doi:
10.1016/j.jchromb.2014.09.013. [PMID: 25264916] - Zeng-Liang Jin, Nana Gao, Dan Zhou, Mu-Gen Chi, Xue-Mei Yang, Jiang-Ping Xu. The extracts of Fructus Akebiae, a preparation containing 90\% of the active ingredient hederagenin: serotonin, norepinephrine and dopamine reuptake inhibitor.
Pharmacology, biochemistry, and behavior.
2012 Jan; 100(3):431-9. doi:
10.1016/j.pbb.2011.10.001. [PMID: 22005599] - He Zhu, Li Ding, Shailendra Shakya, Xiemin Qi, Linlin Hu, Xiaolin Yang, Zhonglin Yang. Simultaneous determination of asperosaponin VI and its active metabolite hederagenin in rat plasma by liquid chromatography-tandem mass spectrometry with positive/negative ion-switching electrospray ionization and its application in pharmacokinetic study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2011 Nov; 879(30):3407-14. doi:
10.1016/j.jchromb.2011.09.014. [PMID: 21963276] - Xuemei Yang, Guoliang Li, Lingyun Chen, Cong Zhang, Xinxiang Wan, Jiangping Xu. Quantitative determination of hederagenin in rat plasma and cerebrospinal fluid by ultra fast liquid chromatography-tandem mass spectrometry method.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2011 Jul; 879(21):1973-9. doi:
10.1016/j.jchromb.2011.05.029. [PMID: 21680262] - Yong-Qiang Zhou, Zhong-Lin Yang, Lei Xu, Ping Li, Yu-Zhu Hu. Akebia saponin D, a saponin component from Dipsacus asper Wall, protects PC 12 cells against amyloid-beta induced cytotoxicity.
Cell biology international.
2009 Oct; 33(10):1102-10. doi:
10.1016/j.cellbi.2009.06.028. [PMID: 19615455] - Jongwon Choi, Hyun-Ju Jung, Kyung-Tae Lee, Hee-Juhn Park. Antinociceptive and anti-inflammatory effects of the saponin and sapogenins obtained from the stem of Akebia quinata.
Journal of medicinal food.
2005; 8(1):78-85. doi:
10.1089/jmf.2005.8.78. [PMID: 15857214] - Yvan Gaillard, Pierre Blaise, Alexandre Darré, Thierry Barbier, Gilbert Pépin. An unusual case of death: suffocation caused by leaves of common ivy (Hedera helix). Detection of hederacoside C, alpha-hederin, and hederagenin by LC-EI/MS-MS.
Journal of analytical toxicology.
2003 May; 27(4):257-62. doi:
10.1093/jat/27.4.257. [PMID: 12820750]