Methyl 9-acetyloxy-2-(furan-3-yl)-6a,10b-dimethyl-4-oxo-1,2,4a,5,6,7,8,9-octahydrobenzo[f]isochromene-7-carboxylate (BioDeep_00001006033)
代谢物信息卡片
Methyl 9-acetyloxy-2-(furan-3-yl)-6a,10b-dimethyl-4-oxo-1,2,4a,5,6,7,8,9-octahydrobenzo[f]isochromene-7-carboxylate
化学式: C23H28O7 (416.1834938)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(=O)OC1CC(C2(CCC3C(=O)OC(CC3(C2=C1)C)C4=COC=C4)C)C(=O)OC
InChI: InChI=1S/C23H28O7/c1-13(24)29-15-9-17(20(25)27-4)22(2)7-5-16-21(26)30-18(14-6-8-28-12-14)11-23(16,3)19(22)10-15/h6,8,10,12,15-18H,5,7,9,11H2,1-4H3
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Ana Elda Maqueda, Marta Valle, Peter H Addy, Rosa Maria Antonijoan, Montserrat Puntes, Jimena Coimbra, Maria Rosa Ballester, Maite Garrido, Mireia González, Judit Claramunt, Steven Barker, Izabela Lomnicka, Marian Waguespack, Matthew W Johnson, Roland R Griffiths, Jordi Riba. Naltrexone but Not Ketanserin Antagonizes the Subjective, Cardiovascular, and Neuroendocrine Effects of Salvinorin-A in Humans.
The international journal of neuropsychopharmacology.
2016 07; 19(7):. doi:
10.1093/ijnp/pyw016. [PMID: 26874330] - Cláudia Margalho, Francisco Corte-Real, Manuel López-Rivadulla, Eugenia Gallardo. Salvia divinorum: toxicological aspects and analysis in human biological specimens.
Bioanalysis.
2016 Jul; 8(13):1415-25. doi:
10.4155/bio-2016-0067. [PMID: 27277872] - Matthew W Johnson, Katherine A MacLean, Michael J Caspers, Thomas E Prisinzano, Roland R Griffiths. Time course of pharmacokinetic and hormonal effects of inhaled high-dose salvinorin A in humans.
Journal of psychopharmacology (Oxford, England).
2016 Apr; 30(4):323-9. doi:
10.1177/0269881116629125. [PMID: 26880225] - Bronwyn Kivell, Zeljko Uzelac, Santhanalakshmi Sundaramurthy, Jeyaganesh Rajamanickam, Amy Ewald, Vladimir Chefer, Vanaja Jaligam, Elizabeth Bolan, Bridget Simonson, Balasubramaniam Annamalai, Padmanabhan Mannangatti, Thomas E Prisinzano, Ivone Gomes, Lakshmi A Devi, Lankupalle D Jayanthi, Harald H Sitte, Sammanda Ramamoorthy, Toni S Shippenberg. Salvinorin A regulates dopamine transporter function via a kappa opioid receptor and ERK1/2-dependent mechanism.
Neuropharmacology.
2014 Nov; 86(?):228-40. doi:
10.1016/j.neuropharm.2014.07.016. [PMID: 25107591] - Cláudia Margalho, Eugenia Gallardo, Alice Castanheira, Duarte Nuno Vieira, Manuel López-Rivadulla, Francisco Corte Real. A validated procedure for detection and quantitation of salvinorin a in pericardial fluid, vitreous humor, whole blood and plasma using solid phase extraction and gas chromatography-mass spectrometry.
Journal of chromatography. A.
2013 Aug; 1304(?):203-10. doi:
10.1016/j.chroma.2013.07.031. [PMID: 23871557] - Ivo Moreno, Beatriz da Fonseca, David Oppolzer, Ana Martinho, Mário Barroso, Angelines Cruz, João António Queiroz, Eugenia Gallardo. Analysis of Salvinorin A in urine using microextraction in packed syringe and GC-MS/MS.
Bioanalysis.
2013 Mar; 5(6):661-8. doi:
10.4155/bio.13.18. [PMID: 23484784] - Mohini Ranganathan, Ashley Schnakenberg, Patrick D Skosnik, Bruce M Cohen, Brian Pittman, R Andrew Sewell, Deepak Cyril D'Souza. Dose-related behavioral, subjective, endocrine, and psychophysiological effects of the κ opioid agonist Salvinorin A in humans.
Biological psychiatry.
2012 Nov; 72(10):871-9. doi:
10.1016/j.biopsych.2012.06.012. [PMID: 22817868] - Brian B Barnes, Nicholas H Snow. Analysis of Salvinorin A in plants, water, and urine using solid-phase microextraction-comprehensive two-dimensional gas chromatography-time of flight mass spectrometry.
Journal of chromatography. A.
2012 Feb; 1226(?):110-5. doi:
10.1016/j.chroma.2011.09.056. [PMID: 21999919] - J Fichna, M Dicay, S A Hirota, D Traboulsi, J A Macdonald, A Janecka, P L Beck, J K Zjawiony, W K Macnaughton, M A Storr. Differential effects of salvinorin A on endotoxin-induced hypermotility and neurogenic ion transport in mouse ileum.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.
2011 Jun; 23(6):583-e212. doi:
10.1111/j.1365-2982.2011.01699.x. [PMID: 21414104] - John E Mendelson, Jeremy R Coyle, Juan Carlos Lopez, Matthew J Baggott, Keith Flower, E Thomas Everhart, Thomas A Munro, Gantt P Galloway, Bruce M Cohen. Lack of effect of sublingual salvinorin A, a naturally occurring kappa opioid, in humans: a placebo-controlled trial.
Psychopharmacology.
2011 Apr; 214(4):933-9. doi:
10.1007/s00213-010-2103-5. [PMID: 21140258] - Jacob M Hooker, Thomas A Munro, Cécile Béguin, David Alexoff, Colleen Shea, Youwen Xu, Bruce M Cohen. Salvinorin A and derivatives: protection from metabolism does not prolong short-term, whole-brain residence.
Neuropharmacology.
2009 Sep; 57(4):386-91. doi:
10.1016/j.neuropharm.2009.06.044. [PMID: 19591852] - Zeynep S Teksin, Insong J Lee, Noble N Nemieboka, Ahmed A Othman, Vijay V Upreti, Hazem E Hassan, Shariq S Syed, Thomas E Prisinzano, Natalie D Eddington. Evaluation of the transport, in vitro metabolism and pharmacokinetics of Salvinorin A, a potent hallucinogen.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2009 Jun; 72(2):471-7. doi:
10.1016/j.ejpb.2009.01.002. [PMID: 19462483] - K Tsujikawa, K Kuwayama, H Miyaguchi, T Kanamori, Y T Iwata, H Inoue. In vitro stability and metabolism of salvinorin A in rat plasma.
Xenobiotica; the fate of foreign compounds in biological systems.
2009 May; 39(5):391-8. doi:
10.1080/00498250902769967. [PMID: 19280383] - Pamela C McDonough, Justin M Holler, Shawn P Vorce, Thomas Z Bosy, Joseph Magluilo, Marilyn R Past. The detection and quantitative analysis of the psychoactive component of Salvia divinorum, salvinorin A, in human biological fluids using liquid chromatography-mass spectrometry.
Journal of analytical toxicology.
2008 Jul; 32(6):417-21. doi:
10.1093/jat/32.6.417. [PMID: 18652747] - Timothy A Vortherms, Philip D Mosier, Richard B Westkaemper, Bryan L Roth. Differential helical orientations among related G protein-coupled receptors provide a novel mechanism for selectivity. Studies with salvinorin A and the kappa-opioid receptor.
The Journal of biological chemistry.
2007 Feb; 282(5):3146-56. doi:
10.1074/jbc.m609264200. [PMID: 17121830] - Stephen Barnes, Jeevan K Prasain, Chao-Cheng Wang, D Ray Moore. Applications of LC-MS in the study of the uptake, distribution, metabolism and excretion of bioactive polyphenols from dietary supplements.
Life sciences.
2006 Mar; 78(18):2054-9. doi:
10.1016/j.lfs.2005.12.002. [PMID: 16460766] - Mark S Schmidt, Thomas E Prisinzano, Kevin Tidgewell, Wayne Harding, Eduardo R Butelman, Mary J Kreek, Daryl J Murry. Determination of Salvinorin A in body fluids by high performance liquid chromatography-atmospheric pressure chemical ionization.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2005 Apr; 818(2):221-5. doi:
10.1016/j.jchromb.2004.12.041. [PMID: 15734162] - Simona Pichini, Sergio Abanades, Magí Farré, Manuela Pellegrini, Emilia Marchei, Roberta Pacifici, Rafael de la Torre, Piergiorgio Zuccaro. Quantification of the plant-derived hallucinogen Salvinorin A in conventional and non-conventional biological fluids by gas chromatography/mass spectrometry after Salvia divinorum smoking.
Rapid communications in mass spectrometry : RCM.
2005; 19(12):1649-56. doi:
10.1002/rcm.1970. [PMID: 15915477] - Charles Chavkin, Sumit Sud, Wenzhen Jin, Jeremy Stewart, Jordan K Zjawiony, Daniel J Siebert, Beth Ann Toth, Sandra J Hufeisen, Bryan L Roth. Salvinorin A, an active component of the hallucinogenic sage salvia divinorum is a highly efficacious kappa-opioid receptor agonist: structural and functional considerations.
The Journal of pharmacology and experimental therapeutics.
2004 Mar; 308(3):1197-203. doi:
10.1124/jpet.103.059394. [PMID: 14718611] - Mark Mowry, Michael Mosher, Wayne Briner. Acute physiologic and chronic histologic changes in rats and mice exposed to the unique hallucinogen salvinorin A.
Journal of psychoactive drugs.
2003 Jul; 35(3):379-82. doi:
10.1080/02791072.2003.10400021. [PMID: 14621136] - Bryan L Roth, Karen Baner, Richard Westkaemper, Daniel Siebert, Kenner C Rice, SeAnna Steinberg, Paul Ernsberger, Richard B Rothman. Salvinorin A: a potent naturally occurring nonnitrogenous kappa opioid selective agonist.
Proceedings of the National Academy of Sciences of the United States of America.
2002 Sep; 99(18):11934-9. doi:
10.1073/pnas.182234399. [PMID: 12192085]