1-Methyl-2-nitro-1-nitrosoguanidine (BioDeep_00000010002)

 

Secondary id: BioDeep_00001871775

human metabolite blood metabolite


代谢物信息卡片


N-Methyl-n,2-dioxohydrazinecarboximidohydrazide 2-oxide

化学式: C2H5N5O3 (147.039238)
中文名称: 1-甲基-3-硝基-1-亚硝基胍
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CN(C(=N)N[N+](=O)[O-])N=O
InChI: InChI=1S/C2H5N5O3/c1-6(5-8)2(3)4-7(9)10/h1H3,(H2,3,4)

描述信息

D009676 - Noxae > D009153 - Mutagens > D009604 - Nitrosoguanidines

同义名列表

14 个代谢物同义名

N-Methyl-n,2-dioxohydrazinecarboximidohydrazide 2-oxide; N-Methyl-n-nitro-N-nitrosoguanidine; 1-Nitroso-3-nitro-1-methylguanidine; N-methyl-N-nitro-N-nitrosoguanidine; 1-Methyl-1-nitroso-3-nitroguanidine; 1-Methyl-2-nitro-1-nitrosoguanidine; N-nitro-N-nitroso-N-methylguanidine; 1-Methyl-3-nitro-1-nitrosoguanidine; N-Nitroso-N-methyl-n-nitroguanidine; N-Methyl-N-nitroso-n-nitroguanidine; N-Methyl-N-nitrosonitroguanidin; Methylnitronitrosoguanidine; MNNG; MNG



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Fangyuan Zhu, Xiaoze Zhang, Junsong Wen, Yanqing Liu, Yaodong Zhu. Celastrus orbiculatus extract reverses precancerous lesions of gastric cancer by inhibiting autophagy via regulating the PDCD4-ATG5 signaling pathway. The Journal of pharmacy and pharmacology. 2024 Mar; 76(3):257-268. doi: 10.1093/jpp/rgae006. [PMID: 38334432]
  • Yong He, Hong-Hong Liu, Xue-Lin Zhou, Ting-Ting He, Ao-Zhe Zhang, Xin Wang, Shi-Zhang Wei, Hao-Tian Li, Li-Sheng Chen, Lei Chang, Yan-Ling Zhao, Man-Yi Jing. Rutaecarpine Ameliorates Murine N-Methyl-N'-Nitro-N-Nitrosoguanidine-Induced Chronic Atrophic Gastritis by Sonic Hedgehog Pathway. Molecules (Basel, Switzerland). 2023 Aug; 28(17):. doi: 10.3390/molecules28176294. [PMID: 37687125]
  • Dong Xie, Chao Wu, Dan Wang, Bahaji Azami Nisma Lena, Ningning Liu, Guan Ye, Mingyu Sun. Wei-fu-chun tablet halted gastric intestinal metaplasia and dysplasia associated with inflammation by regulating the NF-κB pathway. Journal of ethnopharmacology. 2023 Aug; ?(?):117020. doi: 10.1016/j.jep.2023.117020. [PMID: 37567428]
  • Caicai Xi, Kang Feng, Xuan Chen, Hao Wu, Hongshan Chen, Hui Huang, Zeming Ren, Guanhai Dai, Xiaomin Xue, Huifang Zhou, Zhenmei Lu, Renzhao Wu. Granule Dendrobii suppresses chronic atrophic gastritis induced by N-methyl-N'-nitro-N-nitrosoguanidine by modulating the gastrointestinal bacteria in rats. Cellular and molecular biology (Noisy-le-Grand, France). 2023 Jul; 69(7):205-211. doi: 10.14715/cmb/2023.69.7.33. [PMID: 37715378]
  • Yanning Zhu, Ruyun Ma, Wen Cheng, Mengyao Qin, Weiheng Guo, Ying Qi, Jianye Dai. Sijunzi decoction ameliorates gastric precancerous lesions via regulating oxidative phosphorylation based on proteomics and metabolomics. Journal of ethnopharmacology. 2023 Jul; 318(Pt A):116925. doi: 10.1016/j.jep.2023.116925. [PMID: 37467821]
  • Huiqun Xie, Mengqing Hu, Jiao Yu, Xinyu Yang, Jinmiao Li, Nianjun Yu, Lan Han, Daiyin Peng. Mass spectrometry-based metabolomics reveal Dendrobium huoshanense polysaccharide effects and potential mechanism of N-methyl-N'-nitro-N-nitrosoguanidine -induced damage in GES-1 cells. Journal of ethnopharmacology. 2023 Jun; 310(?):116342. doi: 10.1016/j.jep.2023.116342. [PMID: 36889419]
  • Wenhao Liao, Yueqiang Wen, Jing Wang, Maoyuan Zhao, Shangbin Lv, Nianzhi Chen, Yuchen Li, Lina Wan, Qiao Zheng, Yu Mou, Ziyi Zhao, Jianyuan Tang, Jinhao Zeng. Gallic acid alleviates gastric precancerous lesions through inhibition of epithelial mesenchymal transition via Wnt/β-catenin signaling pathway. Journal of ethnopharmacology. 2023 Feb; 302(Pt A):115885. doi: 10.1016/j.jep.2022.115885. [PMID: 36328204]
  • Zhaofeng Liang, Jiajia Song, Yumeng Xu, Xinyi Zhang, Yue Zhang, Hui Qian. Hesperidin Reversed Long-Term N-methyl-N-nitro-N-Nitroguanidine Exposure Induced EMT and Cell Proliferation by Activating Autophagy in Gastric Tissues of Rats. Nutrients. 2022 Dec; 14(24):. doi: 10.3390/nu14245281. [PMID: 36558440]
  • Zhirong Yi, Qingling Jia, Yili Lin, Yujiao Wang, Jun Cong, Zhijian Gu, Jianghong Ling, Gan Cai. Mechanism of Elian granules in the treatment of precancerous lesions of gastric cancer in rats through the MAPK signalling pathway based on network pharmacology. Pharmaceutical biology. 2022 Dec; 60(1):87-95. doi: 10.1080/13880209.2021.2017980. [PMID: 34962453]
  • Jisheng Peng, Zehui Chen, Huazheng Liang, Jinxiang Yang. Proteomics analyses of Xiaopi granules in N-methyl-N'-nitro-N-nitrosoguanidine-induced gastric epithelial dysplasia rat model using LC-MS. Biomedical chromatography : BMC. 2022 Sep; 36(9):e5414. doi: 10.1002/bmc.5414. [PMID: 35599573]
  • Yue Wu, Yu Li, Xiao-Ming Jin, Guan-Hai Dai, Xuan Chen, Ye-Ling Tong, Ze-Ming Ren, Yu Chen, Xiao-Min Xue, Ren-Zhao Wu. Effects of Granule Dendrobii on chronic atrophic gastritis induced by N-methyl-N'-nitro-N-nitrosoguanidine in rats. World journal of gastroenterology. 2022 Aug; 28(32):4668-4680. doi: 10.3748/wjg.v28.i32.4668. [PMID: 36157922]
  • Shangbin Lv, Xiaodong Chen, Yu Chen, Daoyin Gong, Gang Mao, Caifei Shen, Ting Xia, Jing Cheng, Zhaoliang Luo, Yu Cheng, Weihong Li, Jinhao Zeng. Ginsenoside Rg3 induces apoptosis and inhibits proliferation by down-regulating TIGAR in rats with gastric precancerous lesions. BMC complementary medicine and therapies. 2022 Jul; 22(1):188. doi: 10.1186/s12906-022-03669-z. [PMID: 35840932]
  • Li Zhang, Bingxin Jia, Periyannan Velu, Hong Wu. Corilagin induces apoptosis and inhibits HMBG1/PI3K/AKT signaling pathways in a rat model of gastric carcinogenesis induced by methylnitronitrosoguanidine. Environmental toxicology. 2022 May; 37(5):1222-1230. doi: 10.1002/tox.23478. [PMID: 35103375]
  • Hu Zhang, Qiwei Liu, Chao Zhao, Ying Zhang, Shizhi Wang, Ran Liu, Yuepu Pu, Lihong Yin. The dysregulation of unsaturated fatty acid-based metabolomics in the MNNG-induced malignant transformation of Het-1A cells. Environmental science and pollution research international. 2022 Apr; 29(20):30159-30168. doi: 10.1007/s11356-021-17622-z. [PMID: 34997498]
  • Wenqian Tang, Juan Xue, Lei Luo, Yao Wang, Xin Cai, Yuqing Liu, Dawei Huang, Xiaodong Wang, Tangqing He, Dingbo Lu, Fan Yang. Kangxianruangan granule‑containing serum mediated inhibition of hepatic oval cell differentiation into hepatocellular carcinoma cells via the Wnt‑1/β‑catenin signaling pathway. Molecular medicine reports. 2022 02; 25(2):. doi: 10.3892/mmr.2021.12571. [PMID: 34913065]
  • Jian-Xia Wen, Yu-Ling Tong, Xiao Ma, Rui-Lin Wang, Rui-Sheng Li, Hong-Tao Song, Yan-Ling Zhao. Therapeutic effects and potential mechanism of dehydroevodiamine on N-methyl-N'-nitro-N-nitrosoguanidine-induced chronic atrophic gastritis. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2021 Oct; 91(?):153619. doi: 10.1016/j.phymed.2021.153619. [PMID: 34320422]
  • Yu-Ting Lu, Hua-Yi Liu, Jia-Ju Shang, Yi-Jia Mao, Guang-Ze Ouyang, Liu Yang. [Research progress in establishment of N-methyl-N'-nitro-N-nitroso-guanidine-induced rat model of Precancerous lesion of gastric cancer]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2021 Aug; 46(16):4089-4095. doi: 10.19540/j.cnki.cjcmm.20210316.601. [PMID: 34467718]
  • Yuling Tong, Ruilin Wang, Xia Liu, Miao Tian, Yanling Wang, Yanfei Cui, Wenjun Zou, Yanling Zhao. Zuojin Pill ameliorates chronic atrophic gastritis induced by MNNG through TGF-β1/PI3K/Akt axis. Journal of ethnopharmacology. 2021 May; 271(?):113893. doi: 10.1016/j.jep.2021.113893. [PMID: 33524511]
  • Guoliang Cui, Fei Wei, Muxin Wei, Liqun Xie, Zhenyan Lin, Xiaoke Feng. Modulatory effect of Tagetes erecta flowers essential oils via Nrf2/HO-1/NF-κB/p65 axis mediated suppression of N-methyl-N'nitro-N-nitroguanidine (MNNG) induced gastric cancer in rats. Molecular and cellular biochemistry. 2021 Mar; 476(3):1541-1554. doi: 10.1007/s11010-020-04005-0. [PMID: 33394271]
  • Chie Furihata. Human gastric cancer risk screening: From rat pepsinogen studies to the ABC method. Proceedings of the Japan Academy. Series B, Physical and biological sciences. 2021; 97(8):462-478. doi: 10.2183/pjab.97.023. [PMID: 34629355]
  • Chunyue Yu, Zeqi Su, Yicong Li, Yadong Li, Kaige Liu, Fuhao Chu, Ting Liu, Runhua Chen, Xia Ding. Dysbiosis of gut microbiota is associated with gastric carcinogenesis in rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2020 Jun; 126(?):110036. doi: 10.1016/j.biopha.2020.110036. [PMID: 32172061]
  • Tiantian Cai, Chengzhe Zhang, Xiaohui Zeng, Ziming Zhao, Yan Yan, Xuhua Yu, Lei Wu, Lin Lin, Huafeng Pan. Protective effects of Weipixiao decoction against MNNG-induced gastric precancerous lesions in rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2019 Dec; 120(?):109427. doi: 10.1016/j.biopha.2019.109427. [PMID: 31648165]
  • Yi Zhao, Bingtao Li, Gaoyu Wang, Shuchao Ge, Ximing Lan, Guoliang Xu, Hongning Liu. Dendrobium officinale Polysaccharides Inhibit 1-Methyl-2-Nitro-1-Nitrosoguanidine Induced Precancerous Lesions of Gastric Cancer in Rats through Regulating Wnt/β-Catenin Pathway and Altering Serum Endogenous Metabolites. Molecules (Basel, Switzerland). 2019 Jul; 24(14):. doi: 10.3390/molecules24142660. [PMID: 31340453]
  • Xin Deng, Xingqiu Liang, Xiaoxiao Zhou, Manjun Jiang, Xiaofang Zhao, Lei Fu, Mingkun Liang, Xinyuan Wang, Jian Liang. Protective effect and mechanisms of Weining granule on N-methyl-N'-nitro-N- nitrosoguanidine-induced gastric cancer in rats. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. 2019 06; 39(3):393-401. doi: . [PMID: 32186011]
  • Jingyu Xu, Wei Shen, Bei Pei, Xiaowei Wang, Dazhi Sun, Yongjin Li, LiJuan Xiu, Xuan Liu, Ye Lu, Xuan Zhang, XiaoQiang Yue. Xiao Tan He Wei Decoction reverses MNNG-induced precancerous lesions of gastric carcinoma in vivo and vitro: Regulation of apoptosis through NF-κB pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2018 Dec; 108(?):95-102. doi: 10.1016/j.biopha.2018.09.012. [PMID: 30218863]
  • Zhiqian Yi, Yixi Su, Maonian Xu, Andreas Bergmann, Saevar Ingthorsson, Ottar Rolfsson, Kourosh Salehi-Ashtiani, Sigurdur Brynjolfsson, Weiqi Fu. Chemical Mutagenesis and Fluorescence-Based High-Throughput Screening for Enhanced Accumulation of Carotenoids in a Model Marine Diatom Phaeodactylum tricornutum. Marine drugs. 2018 Aug; 16(8):. doi: 10.3390/md16080272. [PMID: 30081564]
  • Tiantian Cai, Chengzhe Zhang, Ziming Zhao, Siyi Li, Haobin Cai, Xiaodong Chen, Dake Cai, Wei Liu, Yan Yan, Kaifeng Xie, Huafeng Pan, Xiaohui Zeng. The gastric mucosal protective effects of astragaloside IV in mnng-induced GPL rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2018 Aug; 104(?):291-299. doi: 10.1016/j.biopha.2018.04.013. [PMID: 29775897]
  • Bo Xu, An-Ming Zhang, Fang Li, Miao Cui, Ji Han, Qin Cao. XZ-1 regulates cell apoptosis of gastric epithelial dysplasia via NF-κB/p53/Ki67 signaling pathway. Bioscience reports. 2018 06; 38(3):. doi: 10.1042/bsr20171529. [PMID: 29588340]
  • Zhan-Peng Yan, Ting-Ting Xu, Zhen-Tao An, Ying Hu, Wan-Zhen Chen, Fang-Shi Zhu. [Injury of human gastric epithelial GES-1 cells by MNNG and its effects on Wnt/β-catenin signaling pathway]. Sheng li xue bao : [Acta physiologica Sinica]. 2018 Jun; 70(3):262-268. doi: . [PMID: 29926067]
  • Gouri Katre, Namasvi Ajmera, Smita Zinjarde, Ameeta RaviKumar. Mutants of Yarrowia lipolytica NCIM 3589 grown on waste cooking oil as a biofactory for biodiesel production. Microbial cell factories. 2017 Oct; 16(1):176. doi: 10.1186/s12934-017-0790-x. [PMID: 29065878]
  • Anna Kakehashi, Midori Yoshida, Yoshiyuki Tago, Naomi Ishii, Takahiro Okuno, Min Gi, Hideki Wanibuchi. Pueraria mirifica Exerts Estrogenic Effects in the Mammary Gland and Uterus and Promotes Mammary Carcinogenesis in Donryu Rats. Toxins. 2016 11; 8(11):. doi: 10.3390/toxins8110275. [PMID: 27827907]
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  • Yoshikazu Taketa, Kaoru Inoue, Miwa Takahashi, Yohei Sakamoto, Gen Watanabe, Kazuyoshi Taya, Midori Yoshida. Effects of sulpiride and ethylene glycol monomethyl ether on endometrial carcinogenicity in Donryu rats. Journal of applied toxicology : JAT. 2016 Jun; 36(6):769-76. doi: 10.1002/jat.3206. [PMID: 26178146]
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