2-Methylhippuric acid (BioDeep_00000017759)

 

Secondary id: BioDeep_00000415948

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite


Metabolite Card


2-[(2-methylphenyl)formamido]acetic acid

Formula: C10H11NO3 (193.0738896)
Chinese Names: 2-甲基马尿酸
Spectrum Hits: Top Source Homo sapiens(blood) 2.44%

Molecular Structure

SMILES: CC1=C(C=CC=C1)C(=O)NCC(O)=O
InChI: InChI=1S/C10H11NO3/c1-7-4-2-3-5-8(7)10(14)11-6-9(12)13/h2-5H,6H2,1H3,(H,11,14)(H,12,13)

Description

2-Methylhippuric acid is an acyl glycine. Acyl glycines are normally minor metabolites of fatty acids. However, the excretion of certain acyl glycines is increased in several inborn errors of metabolism. In certain cases, the measurement of these metabolites in body fluids can be used to diagnose disorders associated with mitochondrial fatty acid beta-oxidation. Acyl glycines are produced through the action of glycine N-acyltransferase (EC 2.3.1.13) which is an enzyme that catalyzes the chemical reaction: acyl-CoA + glycine <--> CoA + N-acylglycine. 2-Methylhippuric acid is a metabolite of xylene which is an aromatic hydrocarbon widely used as a solvant. Its level can be measured in the urine of workers exposed to xylene (PMID:8689499). 2-Methylhippuric acid is an endogenous phenolic acid metabolite detected after the consumption of whole grain.
Methylhippuric acid is an acyl glycine. Acyl glycines are normally minor metabolites of fatty acids. However, the excretion of certain acyl glycines is increased in several inborn errors of metabolism. In certain cases the measurement of these metabolites in body fluids can be used to diagnose disorders associated with mitochondrial fatty acid beta-oxidation. Acyl glycines are produced through the action of glycine N-acyltransferase (EC 2.3.1.13) which is an enzyme that catalyzes the chemical reaction:
2-(2-Methylbenzamido)acetic acid is a metabolite detected in urine.

Synonyms

19 synonym names

2-[(2-methylphenyl)formamido]acetic acid; 2-(2-Methylbenzamido)acetic acid; N-(2-Methylbenzoyl)-glycine; N-(2-Methylbenzoyl)glycine; Ortho-methylhippuric acid; N-(Methylbenzoyl)-glycine; N-(Methylbenzoyl)glycine; 2-Methylhippuric acid; O-Methylhippuric acid; N-(O-Toluoyl)-glycine; N-(O-Toluoyl)glycine; O-Methylhippic acid; 2-Methylhippic acid; METHYL HIPPURATE; 2-Methylhippate; O-Methylhippate; O-Toluric acid; O-Tolic acid; O-Tolate



Cross Reference

11 cross reference id

Classification Terms

Related Pathways

Reactome(0)

BioCyc(0)

PlantCyc(0)

Biological Process

0 related biological process reactions.

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

3 organism taxonomy source information

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
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Literature Reference

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  • Xiao-Dong Sun, Hai-Long Wu, Zhi Liu, Yue Chen, Jun-Chen Chen, Li Cheng, Yu-Jie Ding, Ru-Qin Yu. Target-based metabolomics for fast and sensitive quantification of eight small molecules in human urine using HPLC-DAD and chemometrics tools resolving of highly overlapping peaks. Talanta. 2019 Aug; 201(?):174-184. doi: 10.1016/j.talanta.2019.03.090. [PMID: 31122409]
  • Daniela Remane, Soeren Grunwald, Henrike Hoeke, Andrea Mueller, Stefan Roeder, Martin von Bergen, Dirk K Wissenbach. Validation of a multi-analyte HPLC-DAD method for determination of uric acid, creatinine, homovanillic acid, niacinamide, hippuric acid, indole-3-acetic acid and 2-methylhippuric acid in human urine. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2015 Aug; 998-999(?):40-4. doi: 10.1016/j.jchromb.2015.06.021. [PMID: 26151191]
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